CAS: 4568-71-2; 3-Benzyl-5-(2-Hydroxyethyl)-4-Methylthiazol-3-Ium Chloride

📜4-甲基-5-(Beta-羟乙基)噻唑,氯化苄置于乙腈,水体系中,用 乙腈 作为反应溶剂,化学反应 24.0H,反应生成 3-苄基羟乙基甲基噻唑氯化锂
参考文献:Preparation Of Vinylglyoxal Derivatives,Novel Vinylglyoxal Derivatives
标题:Preparation Of Vinylglyoxal Derivatives,Novel Vinylglyoxal Derivatives
摘要:通式i的乙烯基乙二醛衍生物 ##str1## 其中r是直链或支链烷基或烯基,环烷基或未取代或取代的苯基,通过以下方法制备:将通式v的双环[2.2.1]庚-5-烯-1-甲醛 ##str2## 自缩合形成通式vii的化合物 ##str3## 或将通式ii的化合物r-Ch.Dbd.O(II)与具有上述含义的r反应,在催化剂的存在下形成通式viii(A)和(B)的混合物 ##str4## 在将通式vii的化合物或通式viii(A)和(B)的化合物氧化为相应的二羰基化合物后,在500oc至700oc和减压条件下进行气相热解,特别是小于10-1Mbar,如有需要,进一步纯化通式i的产物.这些化合物可以用作聚合物系统中的单体组分.

专利信息

专利号:US-9920084-B2
优先权日:2011-08-23
标题 :Ionic tags for synthesis of oligoribonucleotides
发明人：DAMHA MASAD J; HASSLER MATTHEW; CHAN TAK-HANG; NANDYALA MALLIKARJUNA REDDY; DONGA ROBERT ALEXANDER
权利人:DAMHA MASAD J; HASSLER MATTHEW; CHAN TAK HANG; NANDYALA MALLIKARJUNA REDDY; DONGA ROBERT ALEXANDER; THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIV; HONG KONG POLYTECHNIC UNIV
摘要:The invention relates to the chemical synthesis of oligonucleotides, e.g., oligoribonucleotides. In another aspect, the invention relates to compounds of formula (II) processes for making these compounds, and the use thereof in the chemical synthesis of oligonucleotides, e.g., oligoribonucleotides. The invention also relates to methods of synthesis of oligomers, including but not limited to oligopeptides, oligosaccharides and oligonucleotides, particularly oligoribonucleotides and also oligodeoxyribonucleotides, in solution systems, and ionic tag linkers for use in methods provided herein.

专利号:US-9834570-B2
优先权日:2013-06-03
标 题 :One step process for regioselective synthesis of α-acyloxy carbonyls
发明人：SUDALAI ARUMUGAM; REDDI RAMBABU; MALEKAR PUSHPA
权利人:COUNCIL SCIENT IND RES
摘要:A regioselective N-Heterocyclic Carbene (NHC) catalyzed one step process for high yield synthesis of α-acyloxy carbonyl compounds is disclosed.

专利号:US-2024308959-A1
优先权日:2021-06-29
标 题:Processes for the preparation of (s)-2-(4-chloro-2-methoxyphenyl)-2-((3 -methoxy-5-(m ethylsulfonyl)phenyl)amino)-1 -(1h-indol-3-yl)ethenone derivatives
发明人：WU KAI; OOST RIK; SCHWEITZER-CHAPUT BERTRAND; ERIKSSON CARL ARNE MAGNUS; COESEMANS ERWIN
权利人:JANSSEN PHARMACEUTICALS INC
摘要:The present invention relates to novel chiral synthesis of mono- or di-substituted indole compounds of formula (I) n n n n n n n n n n n n wherein: n R 1 is H, R 2 is F and R 3 is H or CH 3 , n R 1 is H, CH 3 or F, R 2 is OCH 3 and R 3 is H and n R 1 is H, R 2 is OCH 3 and R 3 is CH 3 , n R 1 is CH 3 , R 2 is F and R 3 is H, n R 1 is CF 3 or OCF 3 , R 2 is H and R 3 is H, n R 1 is OCF 3 , R 2 is OCH 3 and R 3 is H and n R 1 is OCF 3 , R 2 is H and R 3 is CH 3 .

专利号:US-10207974-B1
优先权日:2017-12-05
标 题 :Synthesis of gamma dicarbonyl and pyrrole compounds
发明人：LASSEN KENNETH M
权利人:CHEVRON PHILLIPS CHEMICAL CO LP
摘要:The present invention discloses processes for producing γ-dicarbonyl compounds by contacting an aldehyde compound, an α,β-unsaturated carbonyl compound, and a catalyst composition in the presence of an amide diluent. The resultant γ-dicarbonyl compounds then can be used to synthesize pyrrole compounds, such as 2,5-dimethylpyrrole.

专利号:US-7432285-B2
优先权日:1999-12-23
标 题 :Nitrosated and nitrosylated cyclooxygenase-2 inhibitors, compositions and methods of use
发明人：BANDARAGE RAMANI R; BANDARAGE UPUL K; FANG XINQIN; GARVEY DAVID S; LETTS L GORDON; SCHROEDER JOSEPH D; TAM SANG W
权利人:NITROMED INC
摘要:The present invention describes novel nitrosated and/or nitrosylated cyclooxygenase 2 (COX-2) inhibitors and novel compositions comprising at least one nitrosated and/or nitrosylated cyclooxygenase 2 (COX-2) inhibitor, and, optionally, at least one compound that donates, transfers or releases nitric oxide, stimulates endogenous synthesis of nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor or is a substrate for nitric oxide synthase, and/or optionally, at least one therapeutic agent. The present invention also provides novel compositions comprising at least one parent COX-2 inhibitor and at least one nitric oxide donor, and, optionally, at least one therapeutic agent. The present invention also provides kits and methods for treating inflammation, pain and fever; for treating and/or improving the gastrointestinal properties of COX-2 inhibitors; for facilitating wound healing; for treating and/or preventing renal toxicity; and for treating and/or preventing other disorders resulting from elevated levels of cyclooxygenase-2.

专利号:EP-2609107-B1
优先权日:2010-08-23
标题 :Block synthesis of oligoribonucleotides
发明人：DAMHA MASAD J; HASSLER MATTHEW; CHAN TAK-HANG; NANDYALA MALLIKARJUNA REDDY; DONGA ROBERT ALEXANDER
权利人:THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING / MCGILL UNIV