CAS: 3672-47-7; 3-(4-Methoxyphenyl)-3-Oxopropanenitrile

上下游产品

5-(4-methoxyphenyl)-1,2-oxazole 3-amino-3-(4-methoxyphenyl)acrylonitrile Methyl 2-Cyano-3-(4-methoxyphenyl)-3-oxopropanoate methyl 4-methoxybenzoate H-pyrazol-3-ylamine5-(4-methoxy-phenyl)-2-(4-phenyl-thiazol-2-yl)-2H-pyrazol-3-ylamine H-pyrazol-3-ylamine2-[4-(4-chloro-phenyl)-thiazol-2-yl]-5-(4-methoxy-phenyl)-2H-pyrazol-3-ylamine H-pyrazol-3-ylamine2-[4-(4-bromo-phenyl)-thiazol-2-yl]-5-(4-methoxy-phenyl)-2H-pyrazol-3-ylamine 3-(4-Methoxy-phenyl)-2-oximino-3-oxo-propionitril

📜S-Methyl 3-Oxo-3-(4-Methoxylphenyl)Propanedithioate置于sodium Azide体系中,用 N,N-二甲基甲酰胺 作为反应溶剂,化学反应 2.0H,以80%的收率获得产物4-甲氧基苯甲酰基乙腈
参考文献:1,3-双(杂)芳基单硫-1,3-二酮与叠氮化钠的反应:通过分子内n-O键形成区域选择性合成3,5-双(杂)芳基异恶唑
标题:1,3-双(杂)芳基单硫-1,3-二酮与叠氮化钠的反应:通过分子内n-O键形成区域选择性合成3,5-双(杂)芳基异恶唑
摘要:据报道,在ibx催化剂存在下,一种有效的新的3,5-双(杂)芳基异恶唑合成涉及1,3-双(杂)芳基单硫-1,3-二酮与叠氮化钠的反应.该反应在室温下以高收率进行,适用于多种底物,包括5-甲基-3-芳基异恶唑的合成,5-甲基-3-芳基异恶唑是几种抗β-内酰胺酶的抗生素中存在的关键亚基.已经提出了形成异恶唑的可能机理.还通过使相应的1-(杂)芳基-1-(甲硫基)-4-(杂)亚芳基-丁-1-烯-反应而合成了一些5-苯乙烯基/芳基丁二烯基-3-(杂)芳基异恶唑.在较高温度下与叠氮化钠共3个.β-酮二硫酯与叠氮化钠的反应显示出可提供高产率的β-酮腈.
DOI:10.1021/acs.Joc.0C02216

专利信息

专利号:US-2009264648-A1
优先权日:2008-01-14
标题:Synthesis of pyrazoles
发明人：CHEW WARREN; WANG ZHENG; CHEAL GLORIA; BERTRAND MARTIAL; POTOSKI JOHN; MIRMEHRABI MAHMOUD; NENCINI ARIANNA; ZANALETTI RICCARDO
权利人:WYETH CORP; SIENA BIOTECH SPA
摘要:The present invention provides compounds and compositions, methods of making them, and methods of using them to modulate α7 nicotinic acetylcholine receptors and/or to treat any of a variety of disorders, diseases, and conditions. Provided compounds can affect, among other things, neurological, psychiatric and/or inflammatory system.

专利号:WO-2009091832-A1
优先权日:2008-01-14
标题 :Synthesis of pyrazoles

专利号:US-11312722-B2
优先权日:2019-05-08
标 题:Hsp90 inhibitors and uses thereof
发明人：BROWN LAUREN ELAINE; HUANG DAVID S; COWEN LEAH E; WHITESELL LUKE; MARCYK PAUL
权利人:UNIV BOSTON; GOVERNING COUNCIL UNIV TORONTO
摘要:Herein is described the design and synthesis of resorcylate aminopyrazole compounds. These compounds show broad, potent and fungal-selective Hsp90 inhibitory activity. These compounds also find use in treating Hsp90 related diseases.