CAS: 350-31-2; 4-Chloro-3-Fluoronitrobenzene

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CAS号100-00-5 对硝基氯苯 | CAS号348-51-6 2-氯氟苯 | CAS号403-19-0 2-氟-4-硝基苯酚 | CAS号367-22-6 4-氯-3-氟苯胺 | CAS号351-28-0 3-氟乙酰苯胺 | CAS号351-31-5 acetic acid-(4-... | CAS号7697-37-2 硝酸 | CAS号455-93-6 2-氟-4-硝基苯甲醚 | CAS号1009-36-5 2-氯-5-硝基苯甲醚 | CAS号93246-53-8 3-氟-4-吗啉基苯胺 | CAS号709-09-1 3,4-二甲氧基硝基苯 | CAS号168828-90-8 (S)-5-(氨基甲基)-3-... | CAS号165800-03-3 利奈唑胺 | CAS号168828-81-7 (3-氟-4-吗啉-4-基苯基... | CAS号2689-39-6 4-(2-氟-4-硝基苯基)吗啉

2-氟-4-硝基苯酚置于4-叔丁基苯酚,五氯化磷体系中,用61%的收率获得产物4-氯-3-氟硝基苯
参考文献:S N Ar反应中的电荷控制.元取代与在3,4-Dihalogenonitrobenzenes对于激活硝基
标题:S N Ar反应中的电荷控制.元取代与在3,4-Dihalogenonitrobenzenes对于激活硝基
摘要:3-氟-4-氯硝基苯和3,5-二氟-4-氯硝基苯与噻吩氧化物阴离子的反应导致氯原子主要通过s N Ar轨道控制过程取代.然而,当使用较硬的亲核试剂(甲醇根阴离子)时,相对于活化硝基而言,氟原子间位的取代在3-氟-4-氯硝基苯的反应中是明显的,而3-氟-4-氯硝基苯的反应主要是5-氟-4的反应.-氯-3-甲氧基硝基苯,几乎不参与3,5-二氟-4-氯硝基苯的反应.动力学测量和理论计算表明,观测到的氟原子的间位取代是s Nar电荷控制的反应,具有松散结合的过渡态.
DOI:10.1016/0040-4020(95)01073-4

专利信息

专利号:CN-1007150-B
优先权日:1987-06-22
标题 :Synthesis of 2,4-dichlor-5-fluor benzoic acid

专利号:US-5756834-A
优先权日:1995-11-11
标 题:Process for preparing fluorinated aromatics
发明人：PASENOK SERGEJ; APPEL WOLFGANG
权利人:HOECHST AG
摘要:It is known to prepare fluorinated aromatic compounds of the formula I in which X, Y and Z can have the meaning specified in the description, by reacting aromatic compounds of the formula II in which X, Y and Z have the meaning specified for formula I, with fluorine in a reaction medium. According to the invention, the direct fluorination is carried out in a reaction medium containing polyfluoroalkanesulfonic acids of the formula IIICFnH3-n(CFY)m-SO3H(III)in which m, n and Y have the meaning specified in the description. By this means, it is possible, particularly advantageously to provide a process, which improves the known processes not only with regard to the selectivity and the yield, but also with respect to the quality of the resulting products of the process in a manner not readily predictable. Fluorinated aromatic compounds of the formula I as intermediates for active compound synthesis.