CAS: 1878-66-6; 2-(4-Chlorophenyl)Acetic Acid

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CAS号201230-82-2 carbon monoxide | CAS号104-83-6 4-氯氯苄 | CAS号14062-24-9 4-氯苯基乙酸乙酯 | CAS号140-53-4 对氯苯乙腈 | CAS号622-95-7 4-氯溴苄 | CAS号1875-88-3 4-氯苯乙醇 | CAS号77295-59-1 1-chloro-4-(2,2... | CAS号52449-43-1 4-氯苯乙酸甲酯 | CAS号62037-06-3 3-氯代亚苄基二溴 | CAS号373-91-1 三氟甲基次氟酸酯 | CAS号10465-92-6 Benzeneacetic a... | CAS号101492-44-8 ethyl 2-(4-chlo... | CAS号5468-66-6 2-对氯苄基苯并咪唑 | CAS号32327-71-2 3-(4-氯苯基)丙腈 | CAS号52449-43-1 4-氯苯乙酸甲酯 | CAS号1195-44-4 1-氯-4-(甲氧基甲基)苯 | CAS号3395-81-1 4-氯苯甲醛二甲基缩醛 | CAS号104-88-1 对氯苯甲醛 | CAS号873-76-7 4-氯苄醇 | CAS号37777-68-7 4-氯-3-硝基苯乙酸

1-氯-4-(2,2-二溴乙烯基)苯置于盐酸,水体系中,用 1,4-二氧六环,乙酸乙酯 用作溶剂,化学反应 38.0H,反应生成对氯苯乙酸
参考文献:一种通过芳基醛的二溴代烯烃衍生物进行碳一碳延伸的有效方法
标题:一种通过芳基醛的二溴代烯烃衍生物进行碳一碳延伸的有效方法
摘要:通过在非常温和的条件下,在水的存在下,它们的二溴代烯烃衍生物与吡咯烷反应,将各种芳基醛有效地转化为一个碳原子扩展的芳基乙酰胺或芳基乙酸.
Doi:10.1016/s0040-4020(02)01324-8

专利信息

专利号:US-2025091989-A1
优先权日:2023-09-19
标 题 :Small molecule protein synthesis modulators
发明人：GYGI DAVID; BAHMANYAR SOGOLE SAMI; HAMANN LAWRENCE
权利人:INTERDICT BIO INC
摘要:The present disclosure provides compounds of the formulae herein (e.g., Formula (I)), and pharmaceutically acceptable salts thereof, which are useful for modulating protein synthesis (e.g., modulating synthesis of BCL-2, MYC, CCND1, MCL-1, ALK, KRAS-G12D). The present disclosure also provides pharmaceutical compositions and kits comprising the compounds, or pharmaceutically acceptable salts thereof, and methods of treating or preventing diseases or disorders (e.g., diseases or disorders associated with BCL-2, MYC, CCND1, MCL-1, ALK, KRAS-G12D) by administering to a subject in need thereof the compounds, or pharmaceutically acceptable salts thereof, or pharmaceutical compositions thereof.

专利号:WO-2014202765-A1
优先权日:2013-06-21
标题 :Preparation of chiral 1-methyl-2,3,4,5-1h-benzodiazepines via asymmetric reduction of alpha-substituted styrenes
发明人：STAVBER GAJ; GAZIC SMILOVIC IVANA; CLUZEAU JEROME; RICHTER FRANK
权利人:LEK PHARMACEUTICALS
摘要:The present invention provides an asymmetric and economic synthesis of 8-chloro-1-methyl-2,3,4,5-tetrahydro-1 H-benzo[d]azepine via novel intermediates applying an asymmetric enzymatic, biomimetic or catalytic reduction. The present invention also provides a novel green asymmetric catalytic reduction adapted for an aqueous medium to be applied in the synthesis of 8-chloro-1-methyl-2,3,4,5-tetrahydro-1 H-benzo[d]azepine or novel intermediates.

专利号:WO-2015014261-A1
优先权日:2013-07-30
标 题:Macrolide compound or salt thereof, synthesis method, pharmaceutical composition, and application thereof
发明人：SHEN SHUNYI; CHEN DAIJIE; GE HAN; ZHANG ZHIHONG; REN YANSONG; LI ZHONGLEI; FAN QIANYONG; ZHANG YUN; XU YIJUN; LI DAN; LI JIAN
权利人:SHANGHAI INSITITUTE OF PHARMACEUTICAL INDUSTRY; CHINA STATE INST PHARM IND
摘要:The present invention discloses a macrolide compound or salt thereof, synthesis method, pharmaceutical composition, and application thereof. The present invention provides a method for preparing a macrolide compound 1, a macrolide compound 1', or a salt thereof; also provided are a macrolide compound 2, macrolide compound 2', or salt thereof, a pharmaceutical composition containing said compound or salt, and the application thereof in the preparation of a pharmaceutical for inhibiting methicillin-resistant Staphylococcus aureus. When one or more of the macrolide compound 2, the macrolide compound 2', the macrolide compound 2 salt, and the macrolide compound 2' salt of the present invention is used together with a β-lactam antibiotic, the inhibiting effect of the β-lactam antibiotic on methicillin-resistant Staphylococcus aureus is significantly increased. This is a new class of potentiator having a good potentiating effect in vitro, alleviating methicillin-resistant Staphylococcus aureus resistance to β-lactam antibiotics, and having good prospects for market development.

专利号:US-2006115880-A1
优先权日:2002-12-03
标 题 :Enzymatic production of acyl flavonoid derivatives
发明人：GHOUL MOHAMED; ENGASSER JEAN-MARC; MOUSSOU PHILIPPE; PAULY GILLES; ARDHAOUI MELIKA; FALCIMAIGNE AUDE
权利人:COGNIS FRANCE SA
摘要:Disclosed is a method for enzymatic synthesis of esters of flavonoid and flavonoid derivatives, according to which a reaction medium containing an organic solvent, a glycosylated flavonoid or aglycon flavonoid, an acyl group donor, and an enzymatic catalyst is produced, b) additional quantities of flavonoid and/or acyl donor are optionally added during the reaction, and c) the obtained esters are separated from the enzymatic particles and the solvent. The inventive method is characterized by maintaining the concentration of water and/or alcohol which are formed during the reaction to below 150 mM. Advantageously, the molar ratio of flavonoid to acyl donor in the reaction medium is maintained in the range from 0.01 to 20.00 during the reaction.

专利号:US-8129560-B2
优先权日:2005-08-15
标 题 :Process for the synthesis of mandipropamid and derivatives thereof
发明人：BOWDEN MARTIN CHARLES; CLARK THOMAS AITCHESON; GIORDANO FANNY; JAU BEAT; SCHNEIDER HANS-DIETER; SEIFERT GOTTFRIED; ZELLER MARTIN; FABER DOMINIK; WISS JUERG
权利人:BOWDEN MARTIN CHARLES; CLARK THOMAS AITCHESON; GIORDANO FANNY; JAU BEAT; SCHNEIDER HANS-DIETER; SEIFERT GOTTFRIED; ZELLER MARTIN; FABER DOMINIK; WISS JUERG; SYNGENTA CROP PROT INC
摘要:A process for the preparation of a compound of formula (I), the process comprising: (i) the reaction of a compound of formula (III), with a compound of formula (IV) to give a compound of formula (II), and (ii) the reaction of the compound of formula (II) with a leaving group, to give the compound of formula (I).

专利号:US-4334079-A
优先权日:1980-11-03
标 题:Synthesis of substituted benzyl esters
发明人：GREENE JAMES M; BUNNELL CHARLES A
权利人:LILLY CO ELI
摘要:A process for preparing certain substituted benzyl esters of phenylacetic acids by esterification in a solvent in which the salt of the acid is insoluble, and in the presence of a phase transfer catalyst.