CAS: 1672658-93-3; (3R,4S,5S,6R)-2-(3-((5-(4-Fluorophenyl)Thiophen-2-yl)Methyl)-4-Methylphenyl)-6-(Hydroxymethyl)Tetrahydro-2H-Pyran-2,3,4,5-Tetraol

该化合物是用于管理2型糖尿病的药物Canagliflozin的制药开发的化学化合物,作为一种杂质,它可能在合成Canagliflozin期间出现,其典型特征是分子结构,包括能够影响其化学行为和稳定性的特定功能组别;Canagliflozin Indurity 10,经常被评估其对最终药物产品功效和安全的潜在影响;该化合物的特性,如溶性,熔点和反应作用,对于了解其在总体配方中的作用至关重要;监管准则往往要求对这种杂质进行鉴定和量化,以确保药品的质量和安全;通常使用HPLC(高效液色谱学)和大规模光谱测量等分析技术来评估药物配方中的不洁性的存在和浓度.

英文名称(3R,4S,5S,6R)-2-(3-((5-(4-Fluorophenyl)Thiophen-2-yl)Methyl)-4-Methylphenyl)-6-(Hydroxymethyl)Tetrahydro-2H-Pyran-2,3,4,5-Tetraol
中文名称卡格列净杂质 08
IUPAC名称(3R,4S,5S,6R)-2-(3-((5-(4-fluorophenyl)thiophen-2-yl)methyl)-4-methylphenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol
其它别名Cagliflozin Impurity 10; D-Glucopyranose, 1-C-[3-[[5-(4-Fluorophenyl)-2-Thienyl]Methyl]-4-Methylphenyl]-; Canagliflozin Impurity 86; (2S,3R,4S,5S,6R)-2-(3-((5-(4-Fluorophenyl)Thiophen-2-Yl)Methyl)-4-Methylphenyl)-Tetrahydro-6-(Hydroxymethyl)-2H-Pyran-2,3,4,5-Tetraol; (2S,3R,5S,6R)-2-(3-((5-(4-Fluorophenyl)Thiophen-2-Yl)Methyl)-4-Methylphenyl)-6-(Hydroxymethyl)Tetrahydro-2H-Pyran-2,3,4,5-Tetraol; (3R,4S,5S,6R)-2-(3-((5-(4-Fluorophenyl)Thiophen-2-Yl)Methyl)-4-Methylphenyl)-6-(Hydroxymethyl)Tetrahydro-2H-Pyran-2,3,4,5-Tetraol (Canagliflozin Impurity); (2R,3R,4R,5S)-2-(Acetoxymethyl)-6-(3-((5-(4-Fluoro-2-((3S,4R,5R,6R)-3,4,5-Triacetoxy-6-(Acetoxymethyl)Tetrahydro-2H-Pyran-2-Yl)Phenyl)Thiophen-2-Yl)Methyl)-4-Methylphenyl)Tetrahydro-2H-Pyran-3,4,5-Triyl Triacetate; 2-(5-Bromo-2-Methylbenzyl)-5-(2-Fluorophenyl)Thiophene
CAS编号1672658-93-3
FDA UNII编号:SUG3G8XH7E
分子式:C24H25FO6S分子量:460.52
产品CID: 846192
产品分类Pharmaceutical Intermediates → Blood Glucose Regulators → Canagliflozin

相似结构搜索
InChIKey: MKOMVMKJXCXABB-KKEQRHKBSA-N
InChI=1S/C24H25FO6S/c1-13-2-5-16(24(30)23(29)22(28)21(27)19(12-26)31-24)10-15(13)11-18-8-9-20(32-18)14-3-6-17(25)7-4-14/h2-10,19,21-23,26-30H,11-12H2,1H3/t19-,21-,22+,23-
计算化学: 氢键受体数8.0氢键供体数5.0可旋转键数5.0

MSDS等安全信息

上下游产品

D-Glucono-1,5-lactone 3-[[5-(4-fluorophenyl)-2-thienyl]methyl]-4-methylphenyl bromide (2-(4-fluorophenyl)-5-[(5-iodo-2-methylphenyl)methyl]thiophene)canagliflozin