CAS: 1132-68-9; (S)-2-Amino-3-(4-Fluorophenyl)Propanoic Acid

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CAS号459-32-5 对氟肉桂酸 | CAS号7761-30-0 3-(4-氟苯基)-2-氧代丙酸 | CAS号39801-54-2 3-(4-fluorophen... | CAS号51-65-0 4-氟-DL-苯丙氨酸 | CAS号135950-34-4 ethyl 2-(benzyl... | CAS号352-11-4 对氟氯苄 | CAS号459-46-1 对氟溴苄 | CAS号453-82-7 N-acetyl-3-fluo... | CAS号41153-30-4 B°C-L-4-氟苯丙氨酸 | CAS号151911-23-8 (R)-3-氨基-3- (4-... | CAS号17543-58-7 CBZ-L-4-氟苯丙氨酸 | CAS号7761-30-0 3-(4-氟苯基)-2-氧代丙酸

对氟肉桂酸置于硫酸氢铵,Encp-E293M Variant体系中,化学反应 22.0H,以95%的收率获得
参考文献:细菌氨裂解酶 Encp:一种用于合成非天然氨基酸的可调生物催化剂
标题:细菌氨裂解酶 Encp:一种用于合成非天然氨基酸的可调生物催化剂
摘要:I类裂解酶家族的酶催化氨向丙烯酸芳基酯的不对称加成,产生作为产物的高价值氨基酸.最近的例子包括使用苯丙氨酸氨裂解酶 (Pal),单独使用或作为去消旋级联的途径(分别提供 (S)-或 (R)-α-苯丙氨酸衍生物),以及真核苯丙氨酸氨基变位酶 (Pam) (R)-β-产物的合成.在此,我们介绍了对来自 Streptomyces Maritimus 的另一个家族成员 Encp 的研究,从而扩展了生物催化工具箱并能够生产缺失的 (S)-β-异构体.发现 Encp 将一系列芳基丙烯酸酯转化为 (S)-α-和 (S)-β-芳基丙氨酸的混合物,其区域选择性与每个底物环上的吸电子/供电子基团的强度相关.野生型酶的低区域选择性通过基于结构的合理设计得到解决,以产生三种对α-或β-产物具有改变偏好的变体.通过检查各种生物催化剂/底物组合,证明可以调整反应的胺化模式,以根据需要实现 99:1 和 1:99 之间的
Doi:10.1021/jacs.5B07326

专利信息

专利号:US-12351573-B2
优先权日:2019-05-09
标 题:Compounds for use in synthesis of peptidomimetics
发明人：AL-ABED YOUSEF; CHENG KAI FAN
权利人:FEINSTEIN INSTITUTES FOR MEDICAL RESEARCH
摘要:Synthesis of O-benzotriazole and O-imidazole synthons are described. Uses of synthons in synthesis of azapeptides and other peptidomimetics, azapeptides and other peptidomimetics synthesized from the synthons and uses of azapeptides and other peptidomimetics are also described.

专利号:US-2023159450-A1
优先权日:2020-05-08
标 题 :Dimers for use in synthesis of peptidomimetics
发明人：AL-ABED YOUSEF; ALTITI AHMAD
权利人:FEINSTEIN INSTITUTES FOR MEDICAL RESEARCH
摘要:Dimers for use in synthesis of peptidomimetics are described. Uses of dimers as synthons in synthesis of azapeptides and other peptidomimetics, azapeptides and other peptidomimetics synthesized from the dimers and uses of azapeptides and other peptidomimetics are also described.

专利号:US-9938509-B2
优先权日:2010-12-08
标 题 :Biocatalysts and methods for the synthesis of armodafinil
发明人：ANG EE LUI; ALVIZO OSCAR; BEHROUZIAN BEHNAZ; CLAY MICHAEL D; COLLIER STEVEN J; EBERHARD ELLEN D; FAN FU; SONG SHIWEI; SMITH DEREK J; WIDEGREN MAGNUS; WILSON ROBERT; XU JUNYE; ZHU JUN
权利人:CODEXIS INC
摘要:The present invention relates to non-naturally occurring polypeptides useful for preparing armodafinil, polynucleotides encoding the polypeptides, and methods of using the polypeptides. The non-naturally occurring polypeptides of the present invention are effective in carrying out biocatalytic conversion of the (i) 2-(benzhydrylsulfinyl)acetamide to (−)-2-[(R)-(diphenylmethyl)sulfinyl]acetamide (armodafinil), or (ii) benzhydryl-thioacetic acid to (R)-2-(benzhydrylsulfinyl)acetic acid, which is a pivotal intermediate in the synthesis of armodafinil, in enantiomeric excess.

专利号:US-10087221-B2
优先权日:2013-03-21
标题 :Synthesis of hydantoin containing peptide products
发明人：HENKEL BERND
权利人:SANOFI AVENTIS DEUTSCHLAND
摘要:The present invention relates to a method of synthesizing a peptide product comprising at least one hydantoin group. The peptide product may be used as a reference material for the quality control of pharmaceutical peptides, particularly for the quality control of exendin peptides. Further, the invention relates to hydantoin building blocks, a method for manufacturing such building blocks and their use for the synthesis of peptide products.

专利号:US-7122628-B2
优先权日:2000-12-22
标 题:Process for the synthesis of a peptide having a Trp residue
发明人：JACKSON STEVEN ALLEN
权利人:IPSEN MFG IRELAND LTD
摘要:A process for the solid phase synthesis of a peptide having at least one thyptophan residue, wherein said method comprises temporarily protecting the indole ring of said tryptophan residue with a side chain protecting group which is labile to a base wherein said protecting group is removed during cleavage of said peptide from the solid support.

专利号:US-2023212788-A1
优先权日:2020-03-26
标 题:New method for automated on-demand biomolecular array synthesis
发明人：ZHANG YIXIN; LIN WEILIN
权利人:UNIV DRESDEN TECH
摘要:The invention provides an amphiphilic coating for the direct and rapid synthesis of an array of peptides and small molecular compounds on a planar surface of a solid support, comprising a hydrophilic chemical structure and a lipophilic group, wherein said peptides and small molecular compounds differ from spot to spot from each other in the chemical structure, characterized in that said amphiphilic coating possesses low wettability to polar aprotic solvents used in the array synthesis; said amphiphilic coating possessing low wettability is designed that it can be converted to a coating possessing high wettability by hydrolysis of the lipophilic group; and said amphiphilic coating comprises an amino group for the reaction with an electrophilic reagent. The invention further provides a solid support comprising said amphiphilic coating and a method for method for the direct and rapid synthesis of an array of peptides and small molecular compounds on a planar surface of a solid support, wherein said planar surface of a solid support comprises said amphiphilic coating. Said method includes the enhancing of the wettability of a glass surface to organic solvents to realize automated on-demand biomolecular array synthesis comprising both, peptides and small molecular compounds. The amphiphilic surface can be switched to a hydrophilic surface, resulting in high density arrays suitable for protein- and cell-based screening.