CAS: 11103-57-4; All-Trans-Retinol

专利信息

专利号:US-9040742-B2
优先权日:2011-12-27
标题:Catalytic synthesis of vitamin A intermediate
发明人：BONRATH WERNER; WUESTENBERG BETTINA; NETSCHER THOMAS; SCHUETZ JAN
权利人:DSM IP ASSETS BV
摘要:The present invention relates to a process of production of a compound, which is useful as an intermediate (building block) in organic synthesis, especially in the synthesis of vitamin A or β-carotene and derivatives thereof, e.g. canthaxanthin, astaxanthin or zeaxanthin.

专利号:US-2005027142-A1
优先权日:2003-08-01
标题 :Method for synthesis of 2,2,6-trimethylcyclohexan-1-one
发明人：KLEINFELD SUSANNE; FISCHER ACHIM; WILZ FRANK; WECKBECKER CHRISTOPH; HUTHMACHER KLAUS
权利人:DEGUSSA
摘要:The present invention relates to a method for synthesis of 2,2,6-trimethylcyclohexan-1-one (TMCH) by partial reduction of 2,6,6-trimethyl-2-cyclohexen-1,4-dione (ketoisophorone, KIP), the reaction being carried out in the gas phase in the presence of oxide catalysts.

专利号:US-5191110-A
优先权日:1987-05-21
标题 :Process for the synthesis of vitamin A and certain ones of derivatives
发明人：SOLLADIE GUY; FORESTIER SERGE; LANG GERARD
权利人:OREAL
摘要:According to this process, one effects a stereospecific reduction of the two hydroxyl groups of an ether-diol by a mixture (titanium trichloride, lithium aluminum hydride) at a temperature between 5° C. and about 40° C. and that optionally, one converts the resulting ether into vitamin A, retinol or retinoic acid. n Application to the synthesis of all-trans compounds selected from the group consisting of vitamin A and its ethers, retinol and retinoic acid, and their 13-cis isomers.

专利号:US-4035425-A
优先权日:1973-04-23
标 题 :Synthesis of Vitamin A, intermediates and conversion thereof to Vitamin A
发明人：OROSHNIK WILLIAM
权利人:SCM CORP
摘要:A synthesis of novel Vitamin A intermediates from beta-ionone is described as well as a conversion of the intermediates to Vitamin A. The length of the conjugated aliphatic side chain of beta-ionone is increased while still ultimately obtaining the desired trans form of Vitamin A. In general, beta-ionone is ethynylated to ethynyl-beta-ionol, the hydroxyl of which is etherified to form an ethynyl-terminated, alkoxy-substituted, beta-ionol intermediate. The intermediate is coupled through its copper derivative with a compound like chloro-isopentenyl acetate to produce a C20 skeleton. By semi-hydrogenation, the acetylenic bond on the C20 skeleton is converted to an ethylenic bond, and by hydrolysis the terminal ester moiety is converted to a hydroxyl group. Treatment with a strong base removes the alkoxy group to produce Vitamin A.

专利号:US-4092366-A
优先权日:1975-04-10
标题:Synthesis of Vitamin A, intermediates and conversion thereof to Vitamin A
发明人：OROSHNIK WILLIAM
权利人:SCM CORP
摘要:A synthesis of novel Vitamin A intermediates from betaionone is described as well as a conversion of the intermediates to Vitamin A. The length of the conjugated aliphatic side chain of beta-ionone is increased while still ultimately obtaining the desired trans form of Vitamin A. In general, beta-ionone is ethynylated to ethynyl-beta-ionol, the hydroxyl of which is etherified to form an ethynyl-terminated, alkoxy-substituted, beta-ionol intermediate. The intermediate is coupled through its copper derivative with a compound like chloro-isopentenyl acetate to produce a C20 skeleton. By semi-hydrogenation, the acetylenic bond on the C20 skeleton is converted to an ethylenic bond, and by hydrolysis the terminal ester moiety is converted to a hydroxyl group. Treatment with a strong base removes the alkoxy group to produce Vitamin A.

专利号:US-3949006-A
优先权日:1972-04-24
标题:Synthesis of vitamin A, intermediates and conversion thereof to vitamin A
发明人：OROSHNIK WILLIAM
权利人:SCM CORP
摘要:A synthesis of novel Vitamin A intermediates from betaionone is described as well as a conversion of the intermediates to Vitamin A. The length of the conjugated aliphatic side chain of beta-ionone is increased while still ultimately obtaining the desired trans form of Vitamin A. In general, beta-ionone is ethynylated to ethynyl-beta-ionol, the hydroxyl of which is etherified to form an ethynyl-terminated, alkoxy-substituted, beta-ionol intermediate. The intermediate is coupled through its copper derivative with a compound like chloro-isopentenyl acetate to produce a C20 skeleton. By semi-hydrogenation, the acetylenic bond on the C20 skeleton is converted to an ethylenic bond, and by hydrolysis the terminal ester moiety is converted to a hydroxyl group. Treatment with a strong base removes the alkoxy group to produce Vitamin A.