CAS: 103-89-9; 4'-Methylacetanilide

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CAS号54582-23-9 Ethanone, 1-(4-... | CAS号108-24-7 乙酸酐 | CAS号106-49-0 对甲苯胺 | CAS号60-35-5 乙酰胺 | CAS号624-31-7 对碘甲苯 | CAS号122-00-9 对甲基苯乙酮 | CAS号64-19-7 冰醋酸 | CAS号106-43-4 对氯甲苯 | CAS号99-99-0 对硝基甲苯 | CAS号75-36-5 乙酰氯 | CAS号101580-70-5 1,2-二溴-4-甲基-5-硝基苯 | CAS号10557-67-2 N-(4-methylphen... | CAS号60956-23-2 3,4-二溴甲苯 | CAS号4755-50-4 4-二甲氨基苯甲酰氯 | CAS号351-83-7 对氟乙酰苯胺 | CAS号20172-34-3 N-(4-methylphen... | CAS号1466-87-1 Acetamide,N-(4-... | CAS号103796-14-1 5-acetylamino-2... | CAS号14596-60-2 N-chloro-N-(4-m... | CAS号94-68-8 N-乙基邻甲苯胺

4-硝基甲苯置于tin(II) Chloride Dihdyrate,氯化胆碱,Sodium Acetate体系中,用 水 用作溶剂,化学反应 0.17H,反应生成4-甲基乙酰苯胺
参考文献:二水氯化锡(II)/氯化胆碱深共熔溶剂:N-芳基乙酰胺和吲哚(吡咯)[1,2-A]喹喔啉快速合成中的氧化还原特性
标题:二水氯化锡(II)/氯化胆碱深共熔溶剂:N-芳基乙酰胺和吲哚(吡咯)[1,2-A]喹喔啉快速合成中的氧化还原特性
摘要:在这篇文章中,报道了氯化锡( Ii)二水合物/氯化胆碱低共熔混合物的物理化学,Ir 和拉曼表征.还通过循环伏安法研究了这种溶剂的氧化还原性质,发现它可以成功地用作电合成和电分析过程的电化学溶剂,并且不需要负电位,正如硝基苯的还原所证实的那样.进一步探索了这种低共熔混合物作为氧化还原溶剂的潜在用途,以从多种硝基芳族化合物开始获得芳族胺和n-芳基乙酰胺.此外,一种构建一系列吲哚(Pyrrolo)[1,2-A]喹喔啉是通过 1-(2-Nitrophenyl)-1 H-Indole(Pyrrole) 与醛类反应而开发的.这个简单的协议为构建目标喹喔啉提供了一种简单的方法,反应时间短,产量高,其中关键步骤涉及串联一锅还原环化-氧化.
Doi:10.1039/d0Ra06871C

专利信息

专利号:US-2004058888-A1
优先权日:2000-01-13
标题:Methods for synthesis of alpha-d-gal (1~>3) gal-containing oligosaccharides
发明人：BORNAGHI LAURENT; DEKANY GYULA; DRINNAN NICHOLAS BARRY; PAPAGEORGIOU JOHN; WEST MICHAEL LEO
摘要:This invention relates to reagents and methods for synthesis of biologically active di- and tri-saccharides comprising α-D-Gal(1→3)-D-Gal. In particular the invention provides novel reagents, intermediates and processes for the solution or solid phase synthesis of α-D-galactopyranosyl-(1→3)-D-galactose, and derivatives thereof. In one preferred embodiments the invention provides a protected monosaccharide building block of general formula (II): in which R 3 is methoxy or methyl; R 1 is H, benzoyl, pivaloyl, 4-chlorobenzoyl, acetyl, chloroacetyl, levulinoyl, 4-methylbenzoyl, benzyl, 3,4-methylenedioxybenzyl, 4-methoxybenzyl, 4-chlorobenzyl, 4-acetamidobenzyl, or 4-azidobenzyl; and R 2 is H, Fmoc, benzoyl, pivaloyl, 4-chlorobenzoyl, acetyl, chloroacetyl, levulinoyl, 4-methylbenzoyl, benzyl, 3,4-methylenedioxybenzyl, 4-methoxybenzyl, 4 -chlorobenzyl, 4-acetamidobenzyl, or 4-azidobenzyl.

专利号:US-2015336866-A1
优先权日:2013-01-01
标题:Synthesis of difluoromethyl ethers and sulfides
发明人：HARTWIG JOHN; FIER PATRICK
权利人:UNIV CALIFORNIA
摘要:The synthesis of difluoromethyl ethers and sulfides with a simple, non-ozone-depleting reagent is described. The difluoromethylation of phenols with this reagent occurs at room temperature within minutes with exceptional functional group tolerance. The mild conditions makes possible tandem processes for the conversion of aryl boronic acids, aryl halides and arenes to difluoromethyl ethers. Mechanistic studies support a reaction pathway involving nucleophilic attack of the phenolate to difluorocarbene.

专利号:US-6951878-B2
优先权日:1998-03-12
标 题:Benzo[b]thiophenyl or tetrahydro-benzo[b]thiophenyl modulators of protein tyrosine phosphatases (PTPases)
发明人：MOELLER NIELS PETER HUNDAHL; ANDERSEN HENRIK SUNE; IVERSEN LARS FOGH; OLSEN OLE HVILSTED; BRANNER SVEN; HOLSWORTH DANIEL DALE; BAKIR FARID; JUDGE LUKE MILBURN; AXE FRANK URBAN; JONES TODD KEVIN; RIPKA WILLIAM CHARLES; GE YU; UYEDA ROY TERUYUKI
权利人:NOVO NORDISK AS
摘要:The present invention provides novel compounds, novel compositions, methods of their use, and methods of their manufacture, where such compounds are pharmacologically useful inhibitors of Protein Tyrosine Phosphatases (PTPase's) such as PTP1B, CD45, SHP-1, SHP-2, PTPα, LAR and HePTP or the like. n The compounds are useful in the treatment of type I diabetes, type II diabetes, impaired glucose tolerance, insulin resistance, obesity, immune dysfunctions including autoimmunity diseases with dysfunctions of the coagulation system, allergic diseases including asthma, osteoporosis, proliferative disorders including cancer and psoriasis, diseases with decreased or increased synthesis or effects of growth hormone, diseases with decreased or increased synthesis of hormones or cytokines that regulate the release of/or response to growth hormone, diseases of the brain including Alzheimer's disease and schizophrenia, and infectious diseases.

专利号:US-6353112-B1
优先权日:1998-07-17
标 题:Sultams: Solid phase and other synthesis of anti-HIV compounds and compositions
发明人：BAKER DAVID C; JIANG BIN
权利人:UNIV TENNESSEE RES CORP
摘要:Biologically active sultams are disclosed which have potent anti-HIV activity. A combinational method of synthesis, which uses a solid support and variants thereof, are described. Biological compositions and method of treating mammals for viral infections with compositions comprising the sultams of the invention, especially HIV are described.

专利号:US-7569686-B1
优先权日:2006-01-27
标题:Compounds and methods for synthesis of bicyclic nucleic acid analogs
发明人：BHAT BALKRISHEN; XIA JIE; SETH PUNIT P; VASQUEZ GUILLERMO; MIGAWA MICHAEL T; ALLERSON CHARLES; PRAKASH THAZHA P; SWAYZE ERIC E
权利人:ISIS PHARMACEUTICALS INC
摘要:The present invention provides compounds and methods of using them for preparing bicyclic nucleosides. The bicyclic nucleosides are useful for preparing chemically modified oligomeric compounds. Oligomeric compounds comprising these bicyclic nucleosides have enhanced properties such as increased nuclease resistance.

专利号:US-9802952-B2
优先权日:2013-07-15
标 题:Method and apparatus for the synthesis of dihydroartemisinin and artemisinin derivatives
发明人：KOPETZKI DANIEL; MCQUADE DAVID TYLER; SEEBERGER PETER H; GILMORE KERRY
权利人:MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WSS E V; MAX-PLANK-GESELLSCHAFT ZUR FÖRDERUNG DER WSS E V
摘要:The present invention is directed to a method for continuous production of dihydroartemisinin and also artemisinin derivatives derived from dihydroartemisinin by using artemisinin or dihydroartemisinic acid (DHAA) as starting material as well as to a continuous flow reactor for producing dihydroartemisinin as well as the artemisinin derivatives. It was found that the reduction of artemisinin to dihydroartemisinin in a continuous process requires a special kind of reactor and a special combination of reagents comprising a hydride reducing agent, at least one activator such as an inorganic activator, at least one solid base, at least one aprotic solvent and at least one C 1 -C 5 alcohol.