CAS: 927870-76-6; 5-Iodo-6-Methylpyridin-2(1H)-One

该化合物其结构上有一个5位置的碘替代物和一个6位置的甲基组,使其成为交叉反应的多用途中间体,如铃木或松木竹木交配.乳腺细胞的存在加强了其在核生殖替代和金属催化变异中的再活动.这一化合物对于建立复杂的循环循环框架(通常用于生物活性分子的开发)特别有用.在标准条件下,高纯度和稳定性确保了要求合成应用的一贯性能.

英文名称5-Iodo-6-Methylpyridin-2(1H)-One
中文名称5-碘-6-甲基吡啶-2(1H)-酮
IUPAC名称5-iodo-6-methylpyridin-2(1H)-one
其它别名2-羟基-5-碘-6-甲基吡啶; 5-碘-6-甲基-2(1H)-吡啶酮; 6-Hydroxy-3-Iodo-2-Methylpyridine
CAS编号927870-76-6
MFCD编号:MFCD09037468
EINECS号:677-433-2
分子式:C6H6INO
分子量:235.02
产品CID: 1966454
产品分类有机原料→分子砌块→芳杂环类化合物→吡啶类化合物

相似结构搜索
InChIKey: UFZSHCNPDKACCS-UHFFFAOYSA-N
InChI=1S/C6H6INO/c1-4-5(7)2-3-6(9)8-4/h2-3H,1H3,(H,8,9)…
计算化学: 氢键受体数1.0氢键供体数1.0可旋转键数0.0

相似化合物

1227515-14-1 944718-23-4 144967-99-7

MSDS等安全信息

GHS象形图
GHS符号GHS07 & GHS05;
注释: Exclamation mark & Corrosion
危险类别特定目标器官毒性 - 单次接触类别3
皮肤腐蚀/刺激类别2
严重眼刺激类别2A
急性毒性类别4(经口)
严重眼损伤类别1
警示词Danger(危险)
危险描述H335 |可能引起呼吸道刺激.
H315 |造成皮肤刺激.
H319 |造成严重眼刺激.
H302 |吞咽有害.
H318 |造成严重眼损伤.
防范说明P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
危险品标志Xi

欧盟法规

C&L通报

上下游产品

2-羟基-6-甲基吡啶 6-Hydroxy-2-Methylpyridine 3279-76-3

合成工艺路线路线简述

2-羟基-6-甲基吡啶置于碘,碳酸氢钠体系中,用二氯甲烷作为反应溶剂,化学反应生成 6-羟基-3-碘-甲基吡啶,3,5-二碘-6-甲基-2(1H)-吡啶酮,3-Iodo-6-Methylpyridin-2-Ol
参考文献:Synthesis And Evaluation Of 2-Anilino-3-Phenylsulfonyl-6-Methylpyridines As Corticotropin-Releasing Factor1 Receptor Ligands
标题:Synthesis And Evaluation Of 2-Anilino-3-Phenylsulfonyl-6-Methylpyridines As Corticotropin-Releasing Factor1 Receptor Ligands
摘要:A Novel Series Of 2-Anilino-3-Phenylsulfonyl-6-Methylpyridines Was Synthesized And Evaluated As Corticotropin-Releasing Factor Receptor Ligands. Structure-Activity Relationship Studies Focused Primarily On Optimization Of The 3-Phenylsulfonyl Group. Compounds Within This Series Were Identified Which Showed Potent Binding Affinity For The Crfi Receptor. Selected Compounds Were Examined In A Rat Pharmacokinetic Study And Were Found To Have Oral Bioavailabilities Ranging From 16 To 35%. (C) 2005 Elsevier Ltd. All Rights Reserved.
DOI:10.1016/j.Bmcl.2005.10.097