CAS: 86060-98-2; Fmoc-Lys(Boc)-Opfp

该化合物是氨酸碱碱的一种受保护的衍生物,通常用于peptide合成."Fmoc"(9-氟辛基乙基)和"Boc"(乙基-丁基碳基)组是保护性群体,防止合成过程中的不必要反应,允许在特定阶段有选择地去保护.五溴二苯醚酯会增强碳酸的再活性,便利形成peptide联结.这种复合物在外表上一般是白色到白的,在二氯甲烷和二甲基芳基酰胺等有机溶剂中溶解,但水中溶解程度较低.在标准实验室条件下,其稳定性使其适合各种合成应用.氟基原子在全氟基苯组中的存在也会影响分子的电子特性,可能影响其再活性和生物系统中的相互作用.

结构式图片

相似化合物

133083-36-0 132990-14-8 86061-04-3

欧盟法规

ECHA物质C&L通报

上下游产品

CAS号771-61-9 五氟苯酚 | CAS号71989-26-9 Nα-芴甲氧羰基-Nε-叔丁氧... | CAS号244633-31-6 4-硝基苯磺酸五氟苯酯 | CAS号14533-84-7 三氟乙酸五氟苯酯 | CAS号2418-95-3 N(e)-B°C-L-赖氨酸 | CAS号88744-04-1 9-芴基甲基五氟苯基碳酸酯 | CAS号69558-55-0 胸腺五肽

合成工艺路线路线简述

  • 合成目标产物 Fmoc-Lys(Boc)-Opfp 主要起始原料 Pentafluorophenyl Trifluoroacetate And Fmoc-Lys(Boc)-Oh
  • 14533-84-7 + 71989-26-9 = 86060-98-2 [标题:Reaction Conditions
    标题:Preparation Of Pentafluorophenyl Esters Of Fmoc Protected Amino Acids With Pentafluorophenyl Trifluoroacetate
    作者:Green,Michael; Berman,Judd
    参考文献:Tetrahedron Letters 日期:1990 卷标:31(41) 页码:5851-2]

    71989-26-9 + 771-61-9 = 86060-98-2
    反应条件:1.1 Reagents: Dicyclohexylcarbodiimide Solvents: Tetrahydrofuran,Ethyl Acetate; 4 H,0 °C; 16 H,Rt
    标题:Synthetic Approaches To Peptides Containing The L-Gln-L-Val-D(S)-Dmt Motif
    作者:Suaifan,Ghadeer A. R. Y.; Arafat,Tawfiq; Threadgill,Michael D.
    参考文献:Bioorganic & Medicinal Chemistry 日期:2007 卷标:15(10) 页码:3474-3488
📜五氟苯酚置于吡啶体系中,用 N,N-二甲基甲酰胺 作为反应溶剂,化学反应 0.75H,反应生成 N-芴甲氧羰基-N'-叔丁氧羰基-L-赖氨酸五氟苯酯
参考文献:Preparation Of Pentafluorophenyl Esters Of Fmoc Protected Amino Acids With Pentafluorophenyl Trifluoroacetate
标题:Preparation Of Pentafluorophenyl Esters Of Fmoc Protected Amino Acids With Pentafluorophenyl Trifluoroacetate
摘要:
DOI:10.1016/s0040-4039(00)97976-0

海关参考信息

专利信息


专利号:WO-2004113530-A1
优先权日:2003-06-18
标题:Polynucleotide for synthesis of labeled protein
发明人:NAKA DAIJI; NAKANO HIROSHI; SHIRATORI MIWA; KOBAYASHI TERUAKI; SUZUKI KATSUHIKO; HASHIMOTO HIDEMI; SASAKI TOORU
权利人:MITSUBISHI CHEM CORP; NAKA DAIJI; NAKANO HIROSHI; SHIRATORI MIWA; KOBAYASHI TERUAKI; SUZUKI KATSUHIKO; HASHIMOTO HIDEMI; SASAKI TOORU
摘要:A process for producing a labeled protein, comprising translating a gene template in the presence of a labeled compound having a label portion consisting of a labeled substance and an acceptor portion consisting of a compound capable of binding to the C-terminus of protein synthesized by a translation system. In particular, there are provided a polynucleotide for use in synthesis of labeled protein characterized by having the capability of enhancing labeling efficiency through addition to the 3’ end of a base sequence coding for target protein within the gene template and provided a process for producing a labeled protein that is carried out with the use of the polynucleotide.

专利号:US-5286789-A
优先权日:1989-05-26
标题:Solid phase multiple peptide synthesis
发明人:OKRONGLY DAVID; CLARK BRIAN R; SPESARD JACK
权利人:APPLIED IMMUNESCIENCES
摘要:Methods and compositions are provided, where oligopeptides are produced on a transparent surface while retaining transparency by the cyclical addition of protected monomers. Reagents are specifically selected to allow for efficient reproducible addition, while maintaining transparency of the support. Linkers are provided which permit retention of the oligopeptide to the surface or release of the oligopeptide at completion of the preparation of the oligopeptide. The oligopeptide bound to the support finds use in diagnostic assays, as well as other application, while the free oligopeptides may be used in a variety of ways.

专利号:EP-0400920-B1
优先权日:1989-05-26
标 题 :Solid phase multiple peptide synthesis
发明人:OKRONGLY DAVID; CLARK BRIAN R; SPESARD JACK
权利人:APPLIED IMMUNESCIENCES
摘要:Methods and compositions are provided, where oligopeptides are produced on a transparent surface while retaining transparency by the cyclical addition of protected monomers. Reagents are specifically selected to allow for efficient reproducible addition, while maintaining transparency of the support. Linkers are provided which permit retention of the oligopeptide to the surface or release of the oligopeptide at completion of the preparation of the oligopeptide. The oligopeptide bound to the support finds use in diagnostic assays, as well as other application, while the free oligopeptides may be used in a variety of ways.

供应商参考报价(招募中)

品牌试剂参考报价(招募中)

📌 第三方产品分析报告

✅ COA系统入驻 | 共享模式

合成参考文献


摘要:Ramesh, S.; Cherkupally, P.; Govender, T.; Kruger, H. G.; de la Torre, B. G.; Albericio, F., Science of Synthesis Knowledge Updates, (2017) 1, 359.
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