CAS: 83972-01-4; Magnesium 3-((4-Nitrobenzyl)Oxy)-3-Oxopropanoate

专利信息

专利号:US-2006234990-A1
优先权日:1999-04-30
标题 :Compositions of boswellic acids derived from Boswellia serrata gum resin, for treating lymphoproliferative and autoimmune conditions
发明人：MAJEED MUHAMMED; BADMAEV VLADIMIR
权利人:SAMI LABS LTD
摘要:A method of treatment of lymphoproliferative and autoimmune disorders with a new composition of four boswellic acids including β-boswellic acid, 3-O-acetyl-β-boswellic acid, 11-keto-β-boswellic acid, and 3-O-acetyl-11-keto-β-boswellic acid. Boswellic acids of invention have been obtained in a novel industrial process from the gum resin of Boswellia serrata tree, providing standardized composition which inhibits DNA, RNA and protein synthesis of the target cell without cytotoxic effects. The composition of invention provides advantage of irreversible cytostatic therapy, equivalent to biological effects of a cytotoxic therapy without killing body cells.

专利号:WO-2008058514-A1
优先权日:2006-11-14
标 题:Preparations comprising boswellic acids for inhibiting the synthesis of prostaglandin e2
发明人：WERZ OLIVER; SIEMONEIT ULF
权利人:UNIV EBERHARD KARLS; WERZ OLIVER; SIEMONEIT ULF
摘要:The present invention relates to the use of preparations with pentacyclic triterpenoic acids and structural derivatives thereof, in particular boswellic acids from Boswellia species (such as B. serrata, B. carterii, B. sacra), for inhibiting the inducible mitochondrial prostaglandin E₂ synthase-1. In addition, the invention relates to the use of pentacyclic triterpenoic acids and derivatives thereof for producing a medicament for the treatment of PGE₂-mediated diseases.

专利号:US-9458479-B2
优先权日:2009-12-11
标题 :Method for late introduction of the (8R) hydroxyl group carbapenem β-lactam antibiotic synthesis
发明人：TOWNSEND CRAIG ARTHUR; BODNER MICAH JEFFREY; PHELAN RYAN MARTIN; FREEMAN MICHAEL FRANCIS
权利人:UNIV JOHNS HOPKINS
摘要:The presently disclosed subject matter demonstrates that ThnG and ThnQ enzymes encoded by the thienamycin gene cluster in Streptomyces cattleya oxidize the C-2 and C-6 moieties of carbapenems, respectively. ThnQ stereospecifically hydroxylates PS-5 giving N-acetyl thienamycin. ThnG catalyzes sequential desaturation and sulfoxidation of PS-5, giving PS-7 and its sulfoxide. The ThnG and ThnQ enzymes are relatively substrate selective, but give rise to the oxidative diversity of carbapenems produced by S. cattleya , and orthologues likely function similarly in allied streptomyces.

专利号:US-5134231-A
优先权日:1985-12-28
标题 :3(1-hydoxyethyl)azetidinone compounds and their production
发明人：SUNAGAWA MAKOTO; NOZAKI YOSHIHITO; SASAKI AKIRA; MATSUMURA HARUKI
权利人:SUMITOMO PHARMA
摘要:An amino acid compound of the formula: ##STR1## wherein R is a lower alkyl group, R 1 is a hydrogen atom or a protecting group for carboxyl, R 2 is a hydrogen atom, a protecting group for amino, an optionally substituted allyl group of the formula: ##STR2## (wherein R 3 and R 4 are each a hydrogen atom, a lower alkyl group or an aryl group), a beta-hydroxyethyl group in which the hydroxyl group is optionally protected, a formylmethyl group in which the formyl group is optionally protected, a carboxymethyl group in which the carboxyl group is protected or a 2-furylmethyl group and X is an optionally protected carboxyl group, a hydroxymethyl group in which the hydroxyl group is optionally protected or a substituted mercaptomethyl group of the formula: n n --CH.sub.2 SR.sub.5 n n (wherein R 5 is an aryl group or an ar(lower)alkyl group), which is a useful intermediate in the synthesis of 1-alkylcarbapenem compounds.

专利号:US-4996314-A
优先权日:1986-03-11
标题 :6-(disubstituted amino)carbapenem compounds
发明人：YOSHIOKA TAKEO; CHIDA NORITAKA; WATANABE AZUMA; FUKAGAWA YASUO; ISHIKURA TOMOYUKI
权利人:SANRAKU INC
摘要:A compound represented by the formula ##STR1## wherein R 1 represents a lower alkyl group or a lower haloalkyl group; R 2 represents a lower alkyl group, a lower haloalkyl group, an aralkyl group, or a group of the formula --COOR 4 or --SO 2 R 5 in which R 4 represents an aralkyl group or a substituted or unsubstituted alkyl group and R 5 represents an alkyl group or a substituted or unsubstituted aryl group; and R 3 represents a hydrogen atom or a carboxyl protecting group which can be easily split off. This compound is useful in the production of a 6-(disubstituted amino)carbapenem-series antibiotic. n The compounds of the formula ##STR2## wherein R 1 and R 2 are as defined above are important intermediates for the synthesis of the compounds of formula (I) and/or the aforesaid di-(substituted amino) carbapenem-series antibiotics.

专利号:US-2016083760-A1
优先权日:2009-12-11
标 题:Method for late introduction of the (8r) hydroxyl group carbapenem beta-lactam antibiotic synthesis