CAS: 71989-93-0; 2,4,6-Trihydroxybenzoic Acid Hydrate

专利信息

专利号:US-5386019-A
优先权日:1992-01-15
标 题 :Synthesis of inhibitors of calmodulin-mediated enzymes including KS-501, KS-502 and their enantiomers
发明人：DANISHEFSKY SAMUEL J; DUSHIN Russell; HAIT WILLIAM N
权利人:UNIV YALE
摘要:The total synthesis of a group of compounds with inhibitory effects on calmodulin-mediated enzyme activities has been accomplished. Among these synthesized compounds are KS-501 and KS-502. Other compounds that have been synthesized by the described scheme are ent-KS-501 and ent-KS-502 which are enantiomers of KS-501 and KS-502 and which also have inhibitory effects on calmodulin-mediated enzyme activities.

专利号:US-9217012-B2
优先权日:2009-04-08
标题 :Inhibitors of protein tyrosine phosphatases
发明人：ZHANG ZHONG-YIN; ZHANG SHENG
权利人:ZHANG ZHONG-YIN; ZHANG SHENG; UNIV INDIANA RES & TECH CORP
摘要:Disclosed herein are compounds that selectively inhibit members of the PTP family of enzymes. Synthesized compounds demonstrated selective inhibition of TC-PTP. Also provided are methods of using the compounds and formulations containing the compounds. Also described is a fluorescence-tagged combinatorial library synthesis and screening method. And methods of using these compounds to effect enzyme activity both in cells and in vitro as well as method of using these compounds to treat diseases in human and animals.

专利号:WO-9314099-A1
优先权日:1992-01-15
标题 :Synthesis of inhibitors of calmodulin-mediated enzymes