CAS: 68194-15-0; 2,2',3,4,5,6'-Hexachloro-1,1'-Biphenyl
该化合物是多氯联苯(PCB)家族的成员,这些是合成有机化学品,以其环境持久性和潜在毒性而著称,该化合物由两个双联环组成,六氯原子在特定位置上被替换,显著改变了其物理和化学特性,在室内温度下一般为固体,具有低挥发性和高稳定性,因此耐降解. 2,2',3,4,6,6'-六氯联苯具有水分恐惧症,导致活生物生物体中的生物生物累积,在食物链中可能发生生物放大作用.在许多国家,由于担心其环境影响和健康风险,包括致癌性和内分泌干扰,其使用受到很大限制或禁止.通常使用诸如气相色谱-质谱仪(GC-MS)等分析方法来检测和量化这种化合物在环境样品中的特性.
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- 产品信息参考
;;;; - InChIKey: UQPQKLGBEKEZBV-UHFFFAOYSA-N
- 1S/C12H4Cl6/c13-6-2-1-3-7(14)9(6)5-4-8(15)11(17)12(18)10(5)16/h1-4H
- 计算化学: 氢键受体数*氢键供体数0可旋转键数1
物理性质
MSDS等安全信息
- GHS符号GHS07
- 警示词Warning
- 危险描述H302-H315-H319-H335
- 防范说明P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
- 安全声明The mechanism of action varies with the specific PCB. Dioxin-like PCBs bind to the aryl hydrocarbon receptor, which disrupts cell function by altering the transcription of genes, mainly be inducing the expression of hepatic Phase I and Phase II enzymes, especially of the cytochrome P450 family. Most of the toxic effects of PCBs are believed to be results of Ah receptor binding. Other PBCs are believed to interfere with calcium channels and/or change brain dopamine levels. PCBs can also cause endocrine disurption by altering the production of thyroid hormones and binding to estrogen receptors, which can stimulate the growth of certain cancer cells and produce other estrogenic effects, such as reproductive dysfunction. They will bioaccumulate by binding to receptor proteins such as uteroglobin. (A3, A4, A30, A66)
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1,3-dichloro-2-iodobenzene 2,3,4,5-tetrachloroiodobenzene 2,3,4,9-tetrachlorodibenzofuran 1,2,4,6,8-pentachlorodibenzofuran合成工艺路线路线简述
海关参考信息
- 2903911000-邻二氯苯
- 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
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合成参考文献
摘要:T14: Lewis RJ (1996). Sax's Dangerous Properties of Industrial Materials. 9th ed. Volumes 1-3. New York, NY: Van Nostrand Reinhold.
摘要:L4: ATSDR - Agency for Toxic Substances and Disease Registry (2000). Toxicological profile for polychlorinated biphenyls. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA).
摘要:L134: ATSDR - Agency for Toxic Substances and Disease Registry (2001). Minimal Risk Levels (MRLs) for Hazardous Substances. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA).
摘要:L135: International Agency for Research on Cancer (2014). IARC Monographs on the Evaluation of Carcinogenic Risks to Humans.
摘要:T6: World Health Organization (1993). Environ Health Criteria 140: Polychlorniated Biphenyls and Terphenyls.
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