CAS: 673-32-5; Prop-1-Yn-1-Ylbenzene

上下游产品

phenylethynylmagnesium bromide n-butyllithium diethyl ether (Z)-β-bromo-α-methylstyrene hydratropic acid benzoic acid cis-1-phenyl-1-propylene propargyl benzene

📜菲置于二氯二茂钛,苄基三乙基氯化铵,Magnesium,Sodium Hydroxide,亚磷酸三乙酯体系中,用 四氢呋喃,氘代苯,水 作为反应溶剂,化学反应 12.0H,反应生成 1-苯基-1-丙炔
参考文献:An Experimental And Computational Investigation Of (α-Methylbenzylidene)Carbene
标题:An Experimental And Computational Investigation Of (α-Methylbenzylidene)Carbene
摘要:Photolysis Of 1-(1-Phenylethylidene)-1A,9B-Di-Hydro-1H-Cydopropa[l]Phenanthrene,In C6H6 (Or C6D6),At Ambient Temperature,Produces (A-Methylbenzylidene)Carbene Which Undergoes A Facile Fritsch-Buttenberg-Wiechell (Fbw)-Type Rearrangement To 1-Phenylpropyne. The Alkyne Results Exclusively From A 1,2-Phenyl Shift As Evident From The Use Of A C-13-Labeled Precursor. This Experimental Result Is Consistent With Ccsd(T)/cc-Pvtz//b3Lyp/6-31+g* Calculations Which Reveal That A 1,2-Phenyl Shift In The Singlet Carbene Needs To Overcome A Barrier Of Only 3.8 Kcal/mol Whereas The 1,2-Methyl Shift Has To Surmount A Much Larger Barrier Of 11.9 Kcal/mol. The Alkyne Remains The Predominant Product When The Photolysis Is Carried Out In Cyclohexene But The Carbene-Alkene Cycloadduct Could Be Detected,Albeit In Low Yield,In The Photolysate.
DOI:10.1021/acs.Joc.6B01143

专利信息

专利号:US-10000432-B2
优先权日:2014-01-13
标 题 :Processes for the synthesis of chiral 1-alkanols
发明人：NEGISHI EI-ICHI
权利人:PURDUE RESEARCH FOUNDATION
摘要:The invention relates to highly enantioselective processes for the synthesis of chiral 1-alkanols via Zr-catalyzed asymmetric carboalumination of alkenes.

专利号:US-6737504-B2
优先权日:2001-07-30
标 题 :Synthesis of substituted poly(aniline)s
发明人：FREUND MICHAEL S; SHOJI EIICHI
权利人:CALIFORNIA INST OF TECHN
摘要:A method for preparing a wide range of substituted poly(aniline)s from a single precursor is described. The method uses a variety of reactions, including a boron activation/electrophilic displacement reaction resulting in ipso-substitution. The ability to tune the properties of poly(aniline) through the generation of new structures is useful in numerous fields ranging from polymer-based electronics to sensors.

专利号:US-7109377-B2
优先权日:1996-10-16
标 题:Synthesis of combinatorial libraries of compounds reminiscent of natural products
发明人：SCHREIBER STUART L; SHAIR MATTHEW D; TAN DEREK S; FOLEY MICHAEL A; STOCKWELL BRENT R
权利人:HARVARD COLLEGE
摘要:The present invention provides complex compounds reminiscent of natural products and libraries thereof, as well as methods for their production. The inventive compounds and libraries of compounds are reminiscent of natural products in that they contain one or more stereocenters, and a high density and diversity of functionality. In general, the inventive libraries are synthesized from diversifiable scaffold structures, which are synthesized from readily available or easily synthesizable template structures. In certain embodiments, the inventive compounds and libraries are generated from diversifiable scaffolds synthesized from a shikimic acid based epoxyol template. In other embodiments, the inventive compounds and libraries are generated from diversifiable scaffolds synthesized from the pyridine-based template isonicotinamide. The present invention also provides a novel ortho-nitrobenzyl photolinker and a method for its synthesis. Furthermore, the present invention provides methods and kits for determining one or more biological activities of members of the inventive libraries. Additionally, the present invention provides pharmaceutical compositions containing one or more library members.

专利号:US-2024286903-A1
优先权日:2023-02-24
标 题 :Crystalline Sp-Sp2 Hybridized Carbon Allotropes through Dynamic Covalent Synthesis
发明人：ZHANG WEI; HU YIMING
权利人:UNIV COLORADO REGENTS
摘要:Disclosed is a method for the synthesis of crystalline -graphyne which exhibits an ABC stacking pattern in the crystal structure. Alkyne metathesis is used to reversibly cleave and reform bonds between sp-hybridized carbon atoms to create an sp and sp 2 -hybridized carbon network. An exemplary method includes providing a first hexa-alkynyl substituted benzene co-monomer (e.g., HPB) and a second hexa-alkynyl substituted co-monomer (e.g., HHEB), and undergoing an alkyne metathesis reaction in the presence of a catalyst. During the reaction, small short chain alkyne byproducts can be removed, to drive the reaction toward the formation of the -graphyne polymer product, while the larger alkyne byproducts can facilitate the self-correction process that will minimize the structural defects in the resulting -graphyne.

专利号:US-2023391818-A1
优先权日:2020-11-05
标 题:Peptide synthesis method for suppressing defect caused by diketopiperazine formation
发明人：NOMURA KENICHI; KAGE MIRAI; TAMIYA MINORU; KANAZAWA JUNICHIRO
权利人:CHUGAI PHARMACEUTICAL CO LTD
摘要:Solid-phase synthesis of a peptide has a problem that a desired elongation reaction is prevented from proceeding by diketopiperazine and a 6-membered diamine skeleton compound formed when a protective group at the N-terminal is removed. The present inventors have found that when in production of a peptide by a solid-phase method, a peptide in which an amino group at the N-terminal is protected with a protective group having an Fmoc skeleton is treated in a specific solvent with a base having a pKa of 23 or more in acetonitrile as a conjugate acid, and a peptide chain is then elongated, it is possible to solve the problem described above.

专利号:US-6235957-B1
优先权日:1998-06-29
标 题 :Process for the preparation of cyclopropylacetylene
发明人：CHOUDHURY ANUSUYA
权利人:DU PONT PHARM CO
摘要:The present invention relates generally to novel methods for the synthesis of cyclopropylacetylene which is an essential reagent in the asymmetric synthesis of (S)-6-chloro-4-cyclopropylethynyl-4-trifluoromethyl-1,4-dihydro-2H-3,1-benzoxazin-2-one; a useful human immunodeficiency virus (HIV) reverse transcriptase inhibitor.