CAS: 591-54-8; 4-Aminopyrimidine

相似化合物

2434-56-2 74-69-1 156-81-0

上下游产品

4-氨基-2-氯嘧啶 2-Chloropyrimidin-4-Amine 7461-50-9
4-氨基-2-巯基嘧啶 2-Thiocytosine 333-49-3
4-氨基-6-碘嘧啶 6-Iodopyrimidin-4-Amine 53557-69-0

嘧啶置于potassium Permanganate,Potassium Amide体系中,用 氨 作为反应溶剂,化学反应 0.17H,以72%的收率获得产物4-氨基嘧啶
参考文献:Hara,Hiroshi; Plas,Henk C. Van Der,Journal Of Heterocyclic Chemistry,1982,Vol. 19,P. 1285-1287
标题:Hara,Hiroshi; Plas,Henk C. Van Der,Journal Of Heterocyclic Chemistry,1982,Vol. 19,P. 1285-1287

专利信息

专利号:WO-0119801-A1
优先权日:1999-09-16
标题 :Bioactive substance containing derivatives of 2-amino-6-aryloxypyrimidines and intermediary products of synthesis thereof
发明人：ASHKINAZI RIMMA ILIINICHNA; GANINA MARIYA BORISOVNA; STUDENTSOV EVGENY PAVLOVICH
权利人:ASHKINAZI RIMMA ILIINICHNA; GANINA MARIYA BORISOVNA; STUDENTSOV EVGENY PAVLOVICH
摘要:The invention relates to novel bioactive compounds of the family of pyrimidines and to intermediary products, of the synthesis of such compounds. The novel compounds have a strong antimicrobial activity (especially in respect to a strain of mycobacterium resisting to the existing drugs) and a strong antiviral activity in addition to a strong immunostimulating (interferonogenic) activity while at the same time having a low toxicity level. The derivatives of 2-amino-6-aryloxypyrimidines and intermediary products of the synthesis of such compounds correspond to the following general formula: (formula I) where R1 is preferably selected from a group containing amino, C1-C4 monoalkylamino, dialkylamino, carboxyalkylamino, arylamino, heterylamino groups; R2 represents halogen atoms or an alkyl, hydroxyl, amino or alkoxy group; R3 represents hydrogen or halogen atoms; R4 represents halogen atoms, aryloxy groups with functional X substituents in ortho-, meta- and para positions of the aryl fragment, whereby X substituents are halogen atoms, alkyls C1-C4, cycloalkyl, alkenyl, alkoxy and nitro groups. The invention also relates to the pharmaceutically acceptable salts thereof.

专利号:US-9862687-B2
优先权日:2013-11-15
标题:Morphic forms of hexadecyloxypropyl-phosphonate esters and methods of synthesis thereof
发明人：WARE JR ROY WENDELL; DOWNEY AARON LEIGH
权利人:CHIMERIX INC; CHIMERIX INC
摘要:The disclosure describes methods of synthesis of phosphonate ester compounds. The methods according to the disclosure allow for large-scale preparation of phosphonate ester compounds having high purity and stability. Also disclosed are morphic forms of phosphonate ester compounds.

专利号:US-7105666-B2
优先权日:2002-06-27
标 题:Synthesis of purine derivatives
发明人：HAMMARSTROEM LARS G J; KRAUSS NANCY ELISABTH; LABADIE SHARADA SHENVI; SMITH DAVID BERNARD; TALAMAS FRANCISCO XAVIER
权利人:ROCHE PALO ALTO LLC
摘要:The present invention provides a method for producing 2-, 6-, 8- and 9-substituted purine compounds from 4,6-dihalo-5-nitro-2-alkyl-pyrimidine compounds in solution or by solid phase techniques. The present process provides for the sequential introduction of amine substituents at the 4- and 6-positions, displacement of an alkylsulfony group at the 2-position of the pyrimidine, reduction of the nitro group and formation of the imidazole portion of the purine compound. Furthermore, the methods of the present invention are ideally suited to the preparation of a library of purine compounds.

专利号:US-8252927-B2
优先权日:2008-07-22
标题:Synthesis of substituted 4-amino-pyrimidines
发明人：KARGE REINHARD; LETINOIS ULLA; SHIEFER GERHARD
权利人:KARGE REINHARD; LETINOIS ULLA; SHIEFER GERHARD; DSM IP ASSETS BV
摘要:The present invention is directed to a process for the manufacture of compounds of formula IV wherein R 1 is an amino protecting group, and R 2 is hydrogen or C 1-10 alkyl, comprising a) reacting a compound of formula Ia, wherein M + is a cation, preferably selected from the group consisting of Li + , Na+, K + , ½ Mg 2+ and ½ Zn 2+ , (formula 1 a ) with an ammonium salt NH 4 + X − , wherein X − is an anion, preferably selected from the group consisting of chloride, bromide, sulfate and acetate, in a solvent to a compound of formula II b) reacting a compound of formula II with a nitrile R 2 —CN in the presence of a base to a compound of formula IV. The present invention is further directed to compounds of formula II and their use for the manufacture of vitamin B 1 .

专利号:WO-2025128848-A1
优先权日:2023-12-12
标题:Heterocyclic compounds as triggering receptor expressed on myeloid cells 2 agonists and methods of use
发明人：HOUZE JONATHAN B; PANDYA BHAUMIK
权利人:VIGIL NEUROSCIENCE INC
摘要:The present disclosure provides compounds of Formula (I), useful for the activation of Triggering Receptor Expressed on Myeloid Cells 2 ('TREM2'). This disclosure also provides pharmaceutical compositions comprising the compounds, uses of the compounds, and compositions for treatment of, for example, a neurodegenerative disorder. Further, the disclosure provides intermediates useful in the synthesis of compounds of Formula (I).

专利号:US-8198443-B2
优先权日:2007-01-19
标题 :Synthesis of 4-amino-pyrimidines scaffolds
发明人：BONRATH WERNER; HAERTER RALPH; KARGE REINHARD; LETINOIS ULLA
权利人:BONRATH WERNER; HAERTER RALPH; KARGE REINHARD; LETINOIS ULLA; DSM IP ASSETS BV
摘要:Process for the manufacture of a compound of the structure (I) with R1=hydrogen, alkyl (C1-C10, linear, cyclic or branched, aliphatic or aromatic), NR′R″ (wherein R′ and R″ are independently selected from H, alkyl [C1-C10, linear, cyclic or branched, aliphatic or aromatic] and R2=CH2R3 wherein R3 is selected from NHR1′″ (with R′″=C(O)H, C(O)CH3, C(O)alkyl, CH2C6H2(OMe)3 or other saponifiable residues), alkyl (C1-C10, linear, cyclic or branched) aromatic residues, heteroaryl residues, substituted aryl residues, e.g. 3,4,5-trimethoxy-phenyl) wherein 1 equivalent of an α-formyl-propionitrile salt is reacted with 0.75 to 2 equivalents of an acetamidine salt in the presence of a Lewis acid.