CAS: 55827-50-4; 1-(3,5-Dichlorophenyl)Piperazine

3,5-二氯-1-溴苯置于tris-(Dibenzylideneacetone)Dipalladium(0),R-(+)-1,1'-联萘-2,2'-双二苯膦,三氟乙酸,Sodium T-Butanolate体系中,用 二氯甲烷,甲苯 作为反应溶剂,化学反应 15.0H,反应生成 1-(3,5-二氯苯基)哌嗪
参考文献:具有混合结构的新型苯甘氨酰胺衍生物可作为新型广谱抗惊厥药的候选者
标题:具有混合结构的新型苯甘氨酰胺衍生物可作为新型广谱抗惊厥药的候选者
摘要:在本研究中,应用集中的组合化学方法将众所周知的 Trpv1 拮抗剂的结构片段与我们小组先前发现的强效抗惊厥先导化合物ka-104合并.因此,在体内和体外试验中设计,合成和表征了一系列 22 种原始化合物.获得的化合物在最大电击 (Mes) 测试和 6 Hz 癫痫模型(使用 32 和 44 Ma 电流强度)中显示出强大的体内抗癫痫活性.最有效的化合物53和60显示出以下药理学特征:Ed 50 = 89.7 Mg/kg (Mes),Ed 50 = 29.9 Mg/kg (6 Hz,32 Ma),Ed 50= 68.0 Mg/kg (6 Hz,44 Ma),Ed 50 = 73.6 Mg/kg (Mes),Ed 50 = 24.6 Mg/kg (6 Hz,32 Ma),Ed 50 = 56.3 Mg/kg (6赫兹,44毫安),分别.此外,53和60对iv Ptz 癫痫发作阈值有效,
DOI:10.3390/cells11121862

专利信息

专利号:US-2005019747-A1
优先权日:2002-08-07
标 题 :Nanoliter-scale synthesis of arrayed biomaterials and screening thereof
发明人：ANDERSON DANIEL G; LEVENBERG SHULAMIT; LANGER ROBERT S
摘要:A method of screening cell-polymer interactions. The method includes depositing monomers as a plurality of discrete elements on a substrate, causing the deposited monomers to polymerize, thereby creating an array of discrete polymer elements on the substrate, incubating the substrate in a cell-containing culture medium, and characterizing a predetermined cell behavior on each polymer element.

专利号:US-10995078-B2
优先权日:2013-03-13
标 题:Compounds and compositions for inhibition of FASN
发明人：BAIR KENNETH W; LANCIA JR DAVID R; LI HONGBIN; LOCH JAMES; LU WEI; MARTIN MATTHEW W; MILLAN DAVID S; SCHILLER SHAWN E R; TEBBE MARK J
权利人:FORMA THERAPEUTICS INC
摘要:The present invention relates to compounds and composition for inhibition of FASN, their synthesis, applications, and antidotes. An illustrative compound of the invention is shown below:

专利号:CA-2539670-A1
优先权日:2003-09-15
标 题:Nanoliter-scale synthesis of arrayed biomaterials and screening thereof

专利号:WO-2005028619-A2
优先权日:2003-09-15
标题:Nanoliter-scale synthesis of arrayed biomaterials and screening thereof

专利号:US-6552018-B1
优先权日:1997-01-27
标 题:Pyrazole derivatives
发明人：EJIMA AKIO; OHSUKI SATORU; OHKI HITOSHI; NAITO HIROYUKI
权利人:DAIICHI SEIYAKU CO
摘要:The present invention relates to cis- and trans-forms of pyrazole derivatives, salts thereof, or agents containing the same, and represented by the general formula (I): n wherein G represents a nitrogen containing saturated heterocyclic structure represented by the following formula: n These compounds exhibit anti-tumor activity on 5-FU-resistant tumors and effects on P glycoprotein expressing, multiple-drug resistant tumors. An example of a pyrazole derivative which demonstrates 50% inhibition of tumor cell growth is 3-[4-(3-chloro-5-fluorophenyl)- 1 piperazinyl]-1-[1-(3-chloro-2-pyridyl)-5-methyl-4-pyrazolyl)-1-trans-propene hydrochloride. Synthesis of the compounds represented by formula (I) can be prepared by any one of various routes such as a Mannich reaction, a Wittig reaction, reductive amination or substitution by allylation.

专利号:US-9676721-B2
优先权日:2010-09-03
标题 :Compounds and compositions for the inhibition of NAMPT
发明人：BAIR KENNETH W; BUCKMELTER ALEXANDRE J; HAN BINGSONG; LIN JIAN; REYNOLDS DOMINIC J; SMITH CHASE C; WANG ZHONGGUO; ZHENG XIAOZHANG
权利人:BAIR KENNETH W; BUCKMELTER ALEXANDRE J; HAN BINGSONG; LIN JIAN; REYNOLDS DOMINIC J; SMITH CHASE C; WANG ZHONGGUO; ZHENG XIAOZHANG; FORMA TM LLC
摘要:The present invention relates to compounds and compositions for the inhibition of NAMPT, their synthesis, applications and antidotes. An illustrative compound of the invention is shown below.