CAS: 5534-95-2; (10S,13S,16S)-10-((1H-Indol-3-yl)Methyl)-16-(((S)-1-Amino-1-Oxo-3-Phenylpropan-2-yl)Carbamoyl)-2,2-Dimethyl-13-(2-(Methylthio)Ethyl)-4,8,11,14-Tetraoxo-3-Oxa-5,9,12,15-Tetraazaoctadecan-18-Oic Acid

上下游产品

CAS号5241-58-7 L-苯丙酰胺 | CAS号5609-49-4 cholecystokinin... | CAS号65785-41-3 B°C-β-Ala-ONB | CAS号51987-73-6 N-B°C-L-苯丙氨酸甲酯 | CAS号60058-69-7 (tert-butyloxyc... | CAS号5609-55-2 O-benzylasparty... | CAS号5549-51-9 H-Met-Asp(OBzl)... | CAS号60369-28-0 H2N-Trp-Met-Asp...

📜Z-Asp(Obut)-Phe-Nh2置于钯 N-甲基吗啉,盐酸,氢气,溶剂黄146,N,N'-二环己基碳二亚胺,Honb,乙硫醇体系中,用 甲醇,N,N-二甲基甲酰胺 作为反应溶剂,化学反应 65.75H,反应生成 五肽胃泌素
参考文献:Henklein; Boomgaarden; Nieke,Pharmazie,1988,Vol. 43,# 1,P. 10-11
标题:Henklein; Boomgaarden; Nieke,Pharmazie,1988,Vol. 43,# 1,P. 10-11

专利信息

专利号:US-2024076303-A1
优先权日:2022-09-07
标 题:Green Synthesis of Salicylaldehydate-Metal-Organic Frameworks and Applications Thereof
发明人：SHETTY DINESH; MOHAMMED ABDUL KHAYUM
权利人:UNIV KHALIFA SCIENCE & TECHNOLOGY
摘要:Embodiments of the present disclosure generally describe two-dimensional/three-dimensional conjugated salicylaldehydate metal organic framework (2D/3D-c-SA MOF) compositions, method for green synthesis of the two-dimensional/three-dimensional conjugated salicylaldehydate metal organic framework (2D/3D-c-SA MOF) compositions, applications of the said compositions in supercapacitors, lithium-ion batteries, electrocatalytic conversion reactions, photocatalytic reduction of CO 2 and other uses.

专利号:US-11447454-B2
优先权日:2015-08-07
标题:Synthesis of benzodiazepine derivatives
发明人：BOYCE MALCOLM JAMES; THOMSEN LIV; GILBERT DONALD ALAN; WOOD DAVID
权利人:TRIO MEDICINES LTD
摘要:The invention relates to processes for the synthesis of benzodiazepine derivatives of Formula I:

专利号:US-2004053355-A1
优先权日:2000-05-26
标题:Modular approach to on-line synthesis, drug discovery and biochemical transformations using immobilized enzyme reactors
发明人：WAINER IRVING; MARKOGLOU NEKTARIA
摘要:A coupled system using extremely different enzymes with incompatible cofactors and reaction conditions has been constructed using standard liquid chromatographic formats and open tubular formats. One of the significant aspects of the present invention lies in the development of the liquid chromatographic on-line enzyme cascade. This has been illustrated by the biosynthetic pathway involving dopamine beta-hydroxylase and phenylethanolamine N-methyltransferase which encompass the synthesis of the key neurotransmitters, norepinephrine and epinephrine. The results demonstrate for the first time the immobilization of dopamine beta-hydroxylase and phenylethanolamine N-methyltransferase. The IMERs are active and can be used in a liquid chromatographic format for qualitative and quantitative determinations. The IMER-HPLC system can be used to carry out standard Michaelis-Menten enzyme kinetic studies and to quantitatively determine enzyme kinetic constants, identify specific enzyme inhibitors, provide information regarding the mode of inhibition and the inhibitor constants (K i ). A second significant aspect of the present invention lies in the ability of the immobilized enzyme reactors to be used independently or as a combination, thus providing a unique opportunity to explore the interrelationships between these enzymes, to investigate the source of diseases and to design new drug entities for identified clinical syndromes.

专利号:US-11845970-B2
优先权日:2016-01-15
标 题:Endo-S2 mutants as glycosynthases, method of making and use for glycoengineering of glycoproteins
发明人：WANG LAI-XI; YANG QIANG; LI TIEZHENG; TONG XIN
权利人:UNIV MARYLAND
摘要:The present invention provides for recombinant Endo-S2 mutants (named Endo-S2 glycosynthases) that exhibit reduced hydrolysis activity and increased transglycosylation activity for the synthesis of glycoproteins wherein a desired sugar chain is added to a fucosylated or nonfucosylated GlcNAc-IgG acceptor. As such, the present invention allows for the synthesis and remodeling of therapeutic antibodies thereby providing for certain biological activities, such as, prolonged half-life time in vivo, less immunogenicity, enhanced in vivo activity, increased targeting ability, and/or ability to deliver a therapeutic agent.

专利号:US-12043612-B2
优先权日:2020-05-09
标 题 :Methods of manufacturing a bifunctional compound, ultrapure forms of the bifunctional compound, and dosage forms comprising the same
发明人：ALLAN LAURA E N; CHEN CHUNGPIN HERMAN; DONG HANQING; GROSSO JOHN A; HASKELL III ROYAL J; LLOYD RHYS; REECE HAYLEY
权利人:ARVINAS OPERATIONS INC
摘要:The present disclosure relates to ultra-pure forms, polymorphs, amorphous forms, and formulations of N-[(1r,4r)-4-(3-chloro-4-cyanophenoxy)cyclohexyl]-6-[4-({4-[2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1,3-dioxo-2,3-dihydro-1H-isoindol-5-yl]piperazin-1-yl}methyl)piperidin-1-yl]pyridazine-3-carboxamide, referred to herein as Compound A:The present disclosure also relates methods of manufacturing and purifying the same, as well as intermediates useful in the synthesis of Compound A. The ultra-pure forms, polymorphs, amorphous forms, and formulations of Compound A can be used as therapeutic agents for the treatment of various diseases and conditions such as cancer.

专利号:US-2003147958-A1
优先权日:2002-01-29
标题 :Biodegradable multi-block copolymers of poly(amino acid)s and poly(ethylene glycol) for the delivery of bioactive agents
发明人：AHN CHEOL-HEE; CHAE SU YOUNG
摘要:This patent discloses the synthesis of a multi-block copolymer containing poly(amino acids) (PAA) and a hydrophilic polymer which are degradable under physiological conditions. Control over the degradation rate of the obtained copolymers is achieved by introducing ester, amide or urethane groups as a biodegradable linkage connecting the PAA and the hydrophilic polymer. The biodegradable multi-block copolymers display high transfection efficiency in plasmid delivery with low cytotoxicity.