CAS: 40456-50-6; Yatein
该化合物是属于自然产品类别的化学化合物,主要以其在某些植物物种中出现而闻名,在各种生物活动中可能发挥作用;该化合物的特点是独特的分子结构,有助于其潜在的药理特性;亚廷研究其对各种生物系统的影响,包括潜在的反炎和抗氧化活动;此外,它可能与特定生物目标发生相互作用,使其对医药化学和药物开发感兴趣;然而,关于该化合物的物理和化学特性,如溶性,熔点和具体的再活动,可能需要通过实验研究或文献审查进一步调查.随着研究的继续,对亚廷特性和应用的理解可能会扩大,突出其在天然产品化学和潜在治疗用途中的重要性.
- 英文名称Yatein
- 中文名称(-)-反式-3-(3,4-亚甲基二氧基苄基)-2-(3,4,5-三甲氧基苄基)丁内酯
- IUPAC名称(3R,4R)-4-(benzo[d][1,3]dioxol-5-ylmethyl)-3-(3,4,5-trimethoxybenzyl)dihydrofuran-2(3H)-one
- 其它别名(-)-Deoxypodorhizone; (3R)-3α-(3,4,5-Trimethoxybenzyl)-4β-(1,3-Benzodioxole-5-Ylmethyl)Tetrahydrofuran-2-One; (3R)-3α-(3,4,5-Trimethoxybenzyl)-4β-[(1,3-Benzodioxole-5-yl)Methyl]-4,5-Dihydrofuran-2(3H)-One; (3R,4R)-3-(3,4,5-Trimethoxybenzyl)-4-(1,3-Benzodioxole-5-Ylmethyl)Tetrahydrofuran-2-One; (3R,4R)-3-(3,4,5-Trimethoxybenzyl)-4-[(1,3-Benzodioxol-5-yl)Methyl]Dihydrofuran-2(3H)-One; Yatein; (+)-Deoxypodorhizon; (3S)-3β-(3,4,5-Trimethoxybenzyl)-4α-[(1,3-Benzodioxole-5-yl)Methyl]-4,5-Dihydrofuran-2(3H)-One
- CAS编号40456-50-6
- MFCD编号:MFCD20274740
- 分子式:C22H24O7分子量:400.43
- 产品CID: 1417884
- 产品分类天然产物 → 木脂素
物理性质
- 沸点564.9±45.0 °C(预测)
- 闪点246.2 °C
- 密度1.266±0.06 g/cm3(预测)
- PSA:72.45
- LogP:3.0155
- 蒸汽压8.82E-13 mmHg at 25 °C
- 溶解性Soluble In DMSO
- 外观形态无色至淡黄色固体
- 储存条件储存在 -20°C
- 产品应用该化合物是与CLEITASTHUSBOIVINIANU或CHAMAECYPARIS OBTUSA分离的天然产品. YATEINS通过中断早期基因表达方式,抑制HELA细胞中一型的雌性肝素简单病毒复制. 雅丁的抗病毒行动机制似乎受到了调解,它抑制了HSV-1Α基因表达,包括IPC0和IPC4基因的表达方式;在HELA细胞中逮捕了H SV-1DNA合成和结构蛋白表达方式. YATEN 显示,HCT-116人类结肠癌细胞线受到反对,IC50 > 10 UM.
上下游产品
4-(1,3-benzodioxol-5-ylmethyl)-4,5-dihydrofuran-2(3H)-one 3,4,5-trimethoxybenzyl bromide (E)-3-(benzo[d][1,3]dioxol-5-yl)allyl 2-bromo-3-(3,4,5-trimethoxyphenyl)propanoate rac-(7'β,8β,8'α)-7-hydroxy-3',4',5'-trimethoxy-3,4-methylenedioxylignan-9',9-olides rac-(7'β,8α,8'percentb)-3',4',5'-trimethoxy-4,5-methylenedioxy-2,7'-cyclolignan-9',9-olide rac-(8α,8'β)-4'-hydroxy-3',5'-dimethoxy-3,4-methylenedioxylignan-9',9-olide trans-6-(hydroxymethyl)-10,11,12-trimethoxy-2,3-methylenedioxy-dibenzo[1a,4a:8a,12a]cyclo°Ctadiene-7-carboxylic acid lactone (+/-)-picrostegane合成工艺路线路线简述
📜(R)-3-Cyano-<<3,4-(Methylenedioxy)Phenyl>Methyl>Propyl Acetate置于lithium Hydroxide,Sodium Hydroxide,Lithium Diisopropyl Amide体系中,用 四氢呋喃 作为反应溶剂,化学反应 22.0H,反应生成 Yatein; (-)-反式-3-(3,4-亚甲基二氧基苄基)-2-(3,4,5-三甲氧基苄基)丁内酯
参考文献:An Efficient Enantioselective Total Synthesis Of Antitumor Lignans: Synthesis Of Enantiomerically Pure 4-Hydroxyalkanenitriles Via An Enzymic Reaction
标题:An Efficient Enantioselective Total Synthesis Of Antitumor Lignans: Synthesis Of Enantiomerically Pure 4-Hydroxyalkanenitriles Via An Enzymic Reaction
摘要:Efficient Preparation Of Optically Pure 4-Hydroxyalkanenitriles,La-F,Was Achieved Via An Enzymatic Reaction Using Lipase Ps (Pseudomonas Sp.). Optically Pure (R)-4-Hydroxy-3-[[3,4-(Methylenedioxy)Phenyl]Methyl]Butanenitrile (1A) Was Applied To The Enantioselective Synthesis Of Three Types Of Antitumor Lignans,(-)-Hinokinin,(-)-Isodeoxypodophyllotoxin,And (+)-Isostegane.
DOI:10.1021/jo00073A034
海关参考信息
- 2902600000-乙苯
2905121000-正丙醇
2907210001-间苯二酚
2907221000-对苯二酚 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
主要参考文献
1: Picking D, Chambers B, Barker J, Shah I, Porter R, Naughton DP, Delgoda R. Inhibition of Cytochrome P450 Activities by Extracts of Hyptis verticillata Jacq.: Assessment for Potential HERB-Drug Interactions. Molecules. 2018 Feb 15;23(2). pii: E430. doi: 10.3390/molecules23020430. doi: 10.1021/np501020m. Epub 2015 Jun 19.
4: Donoso-Fierro C, Tiezzi A, Ovidi E, Ceccarelli D, Triggiani D, Mastrogiovanni F, Taddei AR, Pérez C, Becerra J, Silva M, Passarella D. Antiproliferative activity of yatein isolated from Austrocedrus chilensis against murine myeloma cells: cytological studies and chemical investigations. Pharm Biol. 2015 Mar;53(3):378-85. doi: 10.3109/13880209.2014.922588. Epub 2014 Nov 25. doi: 10.3390/molecules17089506. doi: 10.1016/j.phytochem.2011.08.009. Epub 2011 Aug 31. doi: 10.1016/j.phytochem.2011.07.017. Epub 2011 Aug 15. doi: 10.2478/v10102-011-0002-1.
10: Chen JJ, Hung HC, Sung PJ, Chen IS, Kuo WL. Aporphine alkaloids and cytotoxic lignans from the roots of Illigera luzonensis. Phytochemistry. 2011 Apr;72(6):523-32. doi: 10.1016/j.phytochem.2010.12.015. doi: 10.1080/14786410902809500. Epub 2011 Jul 8. doi: 10.1016/j.phytochem.2009.02.009. Epub 2009 Mar 28. Epub 2006 Feb 20.
合成参考文献
参考文献:10.1021/np020042w
摘要:Gu J, Park EJ, Totura S, Riswan S, Fong HHS, Pezzuto JM, Kinghorn AD. Constituents of the Twigs of Hernandia ovigera that Inhibit the Transformation of JB6 Murine Epidermal Cells. J. Nat. Prod. 2002 Jun 05;65(7):1065–8. doi: 10.1021/np020042w.
📝 需求与反馈
尽可能描述清楚需求与问题信息
