CAS: 403-90-7; 2-Amino-3-(3-Fluoro-4-Hydroxyphenyl)Propanoic Acid

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CAS号556-02-5 D-酪氨酸 | CAS号351-52-0 3-氟-4-甲氧基苄基氯 | CAS号330-40-5 N-acetyl-3-fluo... | CAS号457-02-3 2-amino-3-(4-am... | CAS号562-60-7 α-Acetamido-α-[... | CAS号327-87-7 2-(3-fluoro-4-m...

📜Dl-酪氨酸置于fluorine体系中,用 三氟乙酸 作为反应溶剂,化学反应生成 间氟-Dl-酪氨酸
参考文献:[18 F] 5-氟-3-硝基-1-酪氨酸的合成
标题:[18 F] 5-氟-3-硝基-1-酪氨酸的合成
摘要:3-硝基-1-酪氨酸的检测已被用作生物基质中"反应性氮物种"的生物标记,并且一直是分析化学领域的一项持续挑战.在这项工作中,合成了氟18标记的5-氟-3-硝基-1-酪氨酸(fnt)作为潜在的放射性示踪剂,以探测3-硝基-1-酪氨酸的生物学命运.[] Fnt的合成是通过[] 3-氟-1-酪氨酸与nano 3在tfa溶剂中于4oc反应5分钟来进行的.相对于[] 3-氟-1-酪氨酸和[] F 2,[] Fnt的放射化学产率(rcy)为96+/-2%,[] 3-氟-1-酪氨酸的放射化学产率为29+/-1%..[还通过在[Fa] (4oc)或无水hf(-65° F)中用[] F 2直接氟化3-硝基-L-酪氨酸和用nano 3硝化l-酪氨酸,然后氟化来完成] Fnt.c)溶剂.后两种合成途径在1小时内以13.5+/-1.5%的rcy产生了[] Fnt.通过使用产品进行了表征,并NMR谱和质谱测定.
DOI:10.1016/s0022-1139(02)00334-2

专利信息

专利号:US-12421534-B2
优先权日:2021-11-10
标 题 :Engineered enzymes and method for the synthesis of diverse tyrosine analogs
发明人：ALMHJELL PATRICK J; ARNOLD FRANCES H
权利人:CALIFORNIA INST OF TECHN
摘要:Provided herein is an engineered tryptophan synthase β-subunit (TrpB) that catalyzes the synthesis of tyrosine, tyrosine analogs, or salts thereof. Also provided herein are methods for preparing tyrosine, tyrosine analogs, or a salt thereof using the engineered TrpB described herein.

专利号:US-12351573-B2
优先权日:2019-05-09
标 题:Compounds for use in synthesis of peptidomimetics
发明人：AL-ABED YOUSEF; CHENG KAI FAN
权利人:FEINSTEIN INSTITUTES FOR MEDICAL RESEARCH
摘要:Synthesis of O-benzotriazole and O-imidazole synthons are described. Uses of synthons in synthesis of azapeptides and other peptidomimetics, azapeptides and other peptidomimetics synthesized from the synthons and uses of azapeptides and other peptidomimetics are also described.

专利号:US-2023159450-A1
优先权日:2020-05-08
标 题 :Dimers for use in synthesis of peptidomimetics
发明人：AL-ABED YOUSEF; ALTITI AHMAD
权利人:FEINSTEIN INSTITUTES FOR MEDICAL RESEARCH
摘要:Dimers for use in synthesis of peptidomimetics are described. Uses of dimers as synthons in synthesis of azapeptides and other peptidomimetics, azapeptides and other peptidomimetics synthesized from the dimers and uses of azapeptides and other peptidomimetics are also described.

专利号:US-2020354404-A1
优先权日:2019-05-09
标 题 :Peptidomimetic agents, synthesis and uses thereof
发明人：AL-ABED YOUSEF
权利人:FEINSTEIN INSTITUTES FOR MEDICAL RESEARCH
摘要:Compounds for use in synthesis of peptidomimetic agents; synthesis of peptidomimetic agents; peptidomimetic diagnostic and therapeutic agents; and uses of the compounds and peptidomimetic agents in drug discovery, diagnosis, prevention and treatment of diseases are described.

专利号:WO-2025128985-A1
优先权日:2023-12-14
标题 :Sulfoxide and sulfone derivatives of thiocarbazates as synthons for azapeptides synthesis and process of using same
发明人：AL-ABED YOUSEF
权利人:FEINSTEIN INSTITUTES FOR MEDICAL RESEARCH
摘要:Provided for herein are sulfoxide and sulfone derivatives of thiocarbazates that have the formula (I): wherein A, R, R 1 , R 2 , and n are defined herein. The compounds may be used as synthons in the synthesis of azaeptides and other aza- amino acid conjugates.

专利号:US-2009311760-A1
优先权日:2006-05-17
标题:Host cells and uses thereof in the microbial production of hydroxylated aromatics
发明人：WERY JAN; WESTERHOF REGINA GERDA MAAIKE; NIJKAMP KARIN
权利人:SCHOEMAKERSTRAAT 97
摘要:The invention relates to the field of the microbial production of substituted aromatics. In particular, it relates to the production of hydroxylated aromatics from renewable carbon stocks, like sugars or glycerol, via the metabolic intermediate L-tyrosine. Provided is a microbial host cell capable of producing at least one hydroxylated aromatic from a renewable carbon source, wherein at least one enzyme of said host cell that is involved in the degradation of said at least one hydroxylated aromatic is disabled and wherein the de novo synthesis of L-phenylalanine (L-Phe) in said host cell is impeded. Also provided is a method for the microbial production of at least one hydroxylated aromatic from a renewable carbon source, comprising culturing a host cell in the presence of exogenous L-Phe and a renewable carbon source and allowing said host cell to produce said at least one hydroxylated aromatic.