CAS: 3705-26-8; Cyclo(-Phe-Pro)
该化合物是一种由氨酸苯丙氨酸苯丙氨和proline组成的循环二酸二酸酯,该化合物具有一种与线性酸相比增强稳定性的循环结构,该化合物的残留物的存在会助长其疏水特性,而其分泌残留物由于其循环结构而具有独特的僵硬性,它会影响peptide的顺质. Cyclo(L-Phe-L-Pro)因其潜在的生物活动而闻名,包括抗微生物和抗氧化性特性,使其对制药和生物化学研究感兴趣.其循环性质还可能影响其与生物受体和酶的相互作用,从而可能导致独特的药理学影响.此外,化合物的溶解性和稳定性可因pH和溶剂条件而不同,而这种条件对于其在药物配制和运载系统中的应用至关重要.
- 英文名称Cyclo(-Phe-Pro)
- 中文名称环(PhE-PRo)
- 其它别名Pyrrolo[1,2-a]pyrazine-1,4-dione,3-benzylhexahydro-, (3S,8aS)- (8CI); Pyrrolo[1,2-a]pyrazine-1,4-dione,hexahydro-3-(phenylmethyl)-, (3S-trans)-; Cyclo(L-Phe-L-Pro); Cyclo(L-Pro-L-Phe); Cyclo(L-phenylalanyl-L-prolyl-); Cyclo(L-prolyl-L-phenylalanyl); L-Phenylalanyl-L-proline lactam; L-Prolyl-L-phenylalanine diketopiperazine; Maculosin 2; Maculosine 2; SMFEI 02
- CAS编号3705-26-8
- MFCD编号:MFCD00038604
- EINECS号:223-047-0
- 分子式:C14H16N2O2分子量:244.29
- 产品CID: 1379892
- 产品分类有机原料 → 有机酸及其衍生物 → 羧酸及其衍生物
物理性质
MSDS等安全信息
上下游产品
Z-DL-Phe-OH acetone 1-(3,4,5-tris(°Ctadecyloxy)benzyl)-2,3,4,6,7,8-hexahydro-1H-pyrimido[1,2-a]pyrimidine (1S)-methyl 2-[(S)-2-amino-3-phenylpropanoyl]cyclopentanecarboxylateN-L-prolyl-L-phenylalanineN-L-prolyl-L-phenylalanine [(S)-1-((3S,8aS)-3-Benzyl-1,4-dioxo-hexahydro-pyrrolo[1,2-a]pyrazine-2-carbonyl)-2-methyl-propyl]-carbamic acid benzyl ester -Phe-Pro-LactamN--Phe-Pro-Lactam N-(d-Lysergyl-L-valyl)-L-phenylalanyl-L-prolin-lactam合成工艺路线路线简述
📜Boc-L-脯氨酸置于溶剂黄146 N-甲基吗啉,盐酸,1-羟基苯并三唑,N,N'-二环己基碳二亚胺体系中,化学反应 3.5H,反应生成环(Phe-Pro)
参考文献:Acetic Acid-Catalyzed Diketopiperazine Synthesis.
标题:Acetic Acid-Catalyzed Diketopiperazine Synthesis.
摘要:当二肽酯在含有0.1 M醋酸的2-丁醇中回流3小时时,得到了光学纯的二酮哌嗪,产率非常好.当使用脯氨酰氨基酸酯作为起始材料时,1至2 M醋酸是最有效的浓度.
Doi:10.1248/cpb.29.233
海关参考信息
- 2902600000-乙苯
2912110000-甲醛
2912120000-乙醛
2921211000-乙二胺 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:DE-1795023-C2
优先权日:1967-08-02
标 题 :Process for the production of 2-benzyloxy-2-isopropylmalonic acid diethyl ester and its use for the production of heterocycles for the total synthesis of reptide alkaloids of ergot
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
主要参考文献
参考标题:Efficient Synthesis Of 2,5-Diketopiperazines Using Microwave Assisted Heating作者:Marcus Tullberg,Morten Grøtli,Kristina Luthman |发布日期:2006.7
摘要:In This Study A General, Efficient And Environmentally Benign Solution Phase Synthesis Of 2,5-Diketopiperazines (Dkps) Using Microwave Assisted Heating In Water Is Described. A Series Of 11 Structurally Different Dkps Have Been Synthesized From Dipeptide Methyl Esters. A Range Of Common Laboratory Solvents Have Been Tested As Well As Different Reaction Times And Temperatures. Both Classic Thermal And
合成参考文献
参考文献:10.1021/np960095b
摘要:Jayatilake GS, Thornton MP, Leonard AC, Grimwade JE, Baker BJ. Metabolites from an Antarctic sponge-associated bacterium, Pseudomonas aeruginosa. J Nat Prod. 1996 Mar;59(3):293–6. doi: 10.1021/np960095b.
参考文献:10.1016/j.bmcl.2011.05.002
摘要:Xu Z, Zhang Y, Fu H, Zhong H, Hong K, Zhu W. Antifungal quinazolinones from marine-derived Bacillus cereus and their preparation. Bioorganic & Medicinal Chemistry Letters. 2011 Jul;21(13):4005–7. doi: 10.1016/j.bmcl.2011.05.002.
参考文献:10.1021/np50106a005
摘要:Barrow CJ, Sun HH. Spiroquinazoline, a novel substance P inhibitor with a new carbon skeleton, isolated from Aspergillus flavipes. J Nat Prod. 1994 Apr;57(4):471–6. doi: 10.1021/np50106a005.
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