CAS: 369-36-8; 2-Fluoro-5-Nitroaniline

上下游产品

CAS号70-34-8 2,4-二硝基氟苯 | CAS号64-17-5 乙醇 | CAS号3622-38-6 2-氯-5-硝基苯并噻唑 | CAS号3543-74-6 5-[双(2-羟乙基)氨基]-... | CAS号364-76-1 4-氟-3-硝基苯胺 | CAS号38962-61-7 5-氨基-2-氟苯磺酸 | CAS号3543-72-4 1-甲基-5-硝基-1H-苯并... | CAS号3543-75-7 盐酸苯达莫司汀 | CAS号3543-73-5 5-氨基-1-甲基-1H-苯并... | CAS号5367-58-8 5-硝基-2-哌啶苯胺 | CAS号41939-61-1 N1-甲基-4-硝基苯-1,2-二胺 | CAS号454-07-9 N-(2-氟-5-硝基苯基)乙酰胺

2,4-二硝基氟苯置于四羟基二硼,异丙醇体系中,用 乙醇 用作溶剂,化学反应 12.0H,以74%的收率获得2-氟-5-硝基苯胺
参考文献:在蓝光,无催化剂条件下化学,位点选择性还原硝基芳烃
标题:在蓝光,无催化剂条件下化学,位点选择性还原硝基芳烃
摘要:在无催化剂,室温条件下,光诱导双氢原子转移和脱氧转硼酸化的串联反应用于将硝基芳烃化学选择性和位点选择性还原为芳基胺,其产率很高.在该反应中,异丙醇 ( I Proh) 用作氢供体和四羟基二硼 [b 2 (Oh) 4] 作为脱氧试剂,具有绿色,廉价和可商购的证书.特别是,广泛的可还原官能团,如卤素(-Cl,-Br 甚至-I),烯基,炔基,醛,酮,羧基和氰基都是可耐受的.此外,与同一分子中的另一个硝基相比,该反应优先还原缺电子位点的硝基.结合实验和理论计算的详细机理研究为反应途径提供了合理的解释.
Doi:10.1016/j.Cclet.2021.11.023

专利信息

专利号:WO-2022213975-A1
优先权日:2021-04-08
标题:Compounds targeting y220c mutant of p53
发明人：LI SUJING; LI AMIN; ZHENG QIAN; Dang Chaojie; FAN XINRUI; LONG WEI; WANG YANPING
权利人:JACOBIO PHARMACEUTICALS CO LTD
摘要:Provided are compounds of formula (I) which can bind to p53 mutant and restore its ability to bind DNA and activate downstream effects involved in tumor suppression. Also provided are the synthesis processes and use of the compounds.

专利号:US-5105012-A
优先权日:1989-03-24
标题 :Catalytic reduction of dinitrobenzenes using a noble metal catalyst and iron or iron salts
发明人：THEODORIDIS GEORGE
权利人:FMC CORP
摘要:There is provided an improved process for the reduction of optionally substituted dinitrobenzenes to the corresponding nitroanilines with high yields which comprises contacting the dinitrobenzene with hydrogen in an acidic medium in the presence of a catalytic amount of a combination of a noble metal hydrogenation catalyst, and iron or an iron salt. Isomer specific reductions may be achieved with those compounds containing suitable directing substituents. The 2-halo-5-nitroanilines which may be produced in this process may be converted via a multi-step synthesis to useful 1-aryl-4-substituted 1,4-dihydro-5H-tetrazol-5-one herbicides.

专利号:US-9353048-B2
优先权日:2011-10-25
标 题 :Compound as KCNQ potassium channel agonist, preparation method therefor and use thereof
发明人：NAN FAJUN; LI MIN; GAO ZHAOBING; CHEN FEI; ZHANG YANGMING; ZHOU PINGZHENG; HU HAINING; XU HAIYAN; LIU SHENG
权利人:SHANGHAI INST MATERIA MEDICA
摘要:The present invention provides compounds having the structure represented by general formula I, pharmaceutically acceptable salts thereofagonist, preparation methods therefor and a use thereof in the preparation of a medicine for the treatment of nervous system diseases. The compounds or pharmaceutical compositions thereof can be used as the KCNQ potassium channel agonist for treating nervous system diseases. Compared to retigabine, a compound in the prior art, the compound of the present invention have the same or better therapeutic effect, are easier for synthesis and storage, and less prone to oxidate deterioration.

专利号:CN-113717089-A
优先权日:2021-09-22
标 题:A kind of fluorinated Cy7 compound and its synthesis method and application

专利号:CN-113717089-B
优先权日:2021-09-22
标题:A kind of fluorinated Cy7 compound and its synthesis method and application