CAS: 357338-13-7; (S)-2-(2-Oxo-4-Propyl-2,5-Dihydro-1H-Pyrrol-1-yl)Butanamide

上下游产品

(S)-2-amino-butanamide 5-hydroxy-4-n-propyl-2,5-dihydrofuran-2-one pentanal 2-methylidenepentanal brivaracetam ((2S)-2-[(4S)-2-oxo-4-propyltetrahydro-1H-pyrrol-1-yl]butanamide)

📜2-丙基丙烯醛置于rucl2(1,3-Dimesityl-Imidazolidin-2-yl)(Pcy3)(=chph),Sodium Tetrahydroborate,乙醇,三乙胺体系中,用 二氯甲烷,甲苯 用作溶剂,化学反应 49.0H,反应生成(Alphas)-Alpha-乙基-2,5-二氢-2-氧代-4-丙基-1H-吡咯-1-乙酰胺
参考文献:溴乙酰胺的正式合成:钯催化氧化环化和环复分解反应构建吡咯烷酮支架的关键.
标题:溴乙酰胺的正式合成:钯催化氧化环化和环复分解反应构建吡咯烷酮支架的关键.
摘要:通过两种不同的途径,利用钯催化的氧化环化和闭环复分解(rcm)作为关键反应,完成了一种短而有效的溴氰西坦合成方法.这两种途径是新颖的,简单的,可扩展的,并且依赖于(e)-戊-2-烯-1-醇和vareladehyde作为市售的起始原料来产生具有非常好总产率的溴西西坦.
Doi:10.1016/j.Tetlet.2019.151249

专利信息

专利号:US-11518741-B2
优先权日:2018-06-20
标题 :Brivaracetam intermediate, preparation method therefor, and preparation method for brivaracetam
发明人：YANG HANRONG; QI YANTAO; LI TAO; WANG BO
权利人:SHANGHAI PUYI CHEMICAL CO LTD
摘要:The present invention relates to a brivaracetam intermediate, a preparation method therefor, and a preparation method for brivaracetam. The steps of the method for preparing brivaracetam described in the present invention are short and the raw materials are cheap, moreover, the method is simple and highly effective without requiring isomer separation by means of column chromatography or asymmetric synthesis, being suitable for industrial large-scale production. In addition, disclosed by the present invention is a compound as shown in formula (II), which may be used for the synthesis of brivaracetam.

专利号:WO-2020148787-A1
优先权日:2019-01-17
标 题:Enantioselective synthesis of brivaracetam and intermediates thereof

专利号:CN-116041240-B
优先权日:2023-02-17
标 题:Asymmetric catalytic hydrogenation synthesis method of brivaracetam intermediate