CAS: 34883-41-5; 3,5-Dichloro-1,1'-Biphenyl

该化合物是属于联苯类别的有机化合物,由两个相连的苯环组成;其特点是,在双苯结构的3和5个位置上存在两个氯原子;这种替代模式影响其物理和化学特性,包括其溶性,稳定性和再活性;通常,3,5-二氯联苯是黄色固体的无色物质,在正常条件下相对稳定;众所周知,它具有疏水性,使其在水中溶解性较低,但在有机溶剂中更易溶解;该化合物由于具有持久性有机污染物的潜力,以及其在与氯化联苯有关的研究及其对健康和生态系统的影响,因此对环境化学具有兴趣;此外,它可能参与各种工业应用,尽管其具体用途可能各不相同;在处理该化合物时,必须采取安全防范措施,因为其潜在的毒性和环境影响.

结构式图片

欧盟法规

ECHA物质C&L通报

上下游产品

1,3,5-trichlorobenzene benzene 1-bromo-3,5-dichlorobenzene iodobenzene m-chlorobiphenyl 3,5-dichlorobenzoic acid biphenyl acetone

合成工艺路线路线简述

    📜1,2,3,5-四氯苯 反应 80.0H,反应生成3,5-二氯联苯
    参考文献:多卤苯在苯中的光反应.三联苯的形成
    标题:多卤苯在苯中的光反应.三联苯的形成
    摘要:多氯苯,多溴苯和多氯多溴苯(c6H6−nxn)在苯溶液中光解;产物采用 Gc/ms 方法分析.脱卤和苯基化都显示出竞争性,产生少一个卤素原子的(多)卤代苯(c6H7-Nxn-1)和(多)卤代联苯(c6H6-Nxn-1-C6H5)作为主要产品.除了这些产品之外,三联苯是通过形成的卤代联苯的连续苯基化产生的.只有当通过 2-氯联苯的途径成为可能时,多氯苯才会形成相应的三联苯;然而,多溴苯可以通过中间形成的任何异构溴联苯产生三联苯.还显示通过氯原子的间迁移发生异构化的程度要小得多.
    Doi:10.1246/bcsj.62.3122

    海关参考信息

    专利信息


    专利号:US-4808607-A
    优先权日:1985-05-22
    标题 :Imidazole analogs of mevalonolactone and derivatives thereof for use in inhibiting cholesterol biosynthesis and lowering blood cholesterol level
    发明人:WAREING JAMES R
    权利人:SANDOZ PHARMACEUTICALS CORP
    摘要:Compounds of the formula and the pharmaceutically acceptable acid addition salts thereof, wherein the various substituents are defined hereinbelow and the use thereof for inhibiting cholesterol biosynthesis and lowering the blood cholesterol level and, therefore, in the treatment of hyperlipoproteinemia and atherosclerosis, pharmaceutical compositions comprising such compounds and processes for and intermediates in the synthesis of such compounds.

    专利号:US-4755606-A
    优先权日:1985-05-22
    标 题 :Imidazolyl-3,5-di-(diphenyl-butylsilyloxy) carboxylic acid ester intermediates
    发明人:WAREING JAMES R
    权利人:SANDOZ PHARMACEUTICALS CORP
    摘要:Compounds of the formula and the pharmaceutically acceptable acid addition salts thereof, wherein the various substituents are defined herein below, the use thereof for inhibiting cholesterol biosynthesis and lowering the blood cholesterol level and, therefore, in the treatment of hyperlipoproteinemia and atherosclerosis, pharmaceutical compositions comprising such compounds and processes for and intermediates in the synthesis of such compounds.

    专利号:EP-3793972-A1
    优先权日:2018-05-15
    标题 :Total synthesis of prostaglandin j natural products by stereoretentive metathesis

    供应商参考报价(招募中)

    品牌试剂参考报价(招募中)

    📌 第三方产品分析报告

    ✅ COA系统入驻 | 共享模式

    主要参考文献

    [参考文献]: H A J Govers, Et Al. Dissolved Organic Carbon--Contaminant Interaction Descriptors Found By 3D Force Field Calculations. Sar Qsar Environ Res. 2002 Mar;13(2):271-80.
    [参考文献]: M W Kennedy, Et Al. Metabolism Of Dichlorobiphenyls By Hepatic Microsomal Cytochrome P-450. Biochem Pharmacol. 1981 Mar 15;30(6):577-88.
    [参考文献]: Nina P Gritsan, Et Al. A Study Of 2-Azido-3,5-Dichlorobiphenyl By Nano- And Picosecond Laser Flash Photolysis And Computational Methods. Photochem Photobiol Sci. 2005 Jan;4(1):23-32.

    合成参考文献


    摘要:Szabó, K. J., Science of Synthesis: Multicomponent Reactions, (2013) 2, 369.
    摘要:S109 | PARCEDC | List of 7074 potential endocrine disrupting compounds (EDCs) by PARC T4.2 | DOI:10.5281/zenodo.10944198
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