专利号:US-4808607-A 优先权日:1985-05-22 标题 :Imidazole analogs of mevalonolactone and derivatives thereof for use in inhibiting cholesterol biosynthesis and lowering blood cholesterol level 发明人:WAREING JAMES R 权利人:SANDOZ PHARMACEUTICALS CORP 摘要:Compounds of the formula and the pharmaceutically acceptable acid addition salts thereof, wherein the various substituents are defined hereinbelow and the use thereof for inhibiting cholesterol biosynthesis and lowering the blood cholesterol level and, therefore, in the treatment of hyperlipoproteinemia and atherosclerosis, pharmaceutical compositions comprising such compounds and processes for and intermediates in the synthesis of such compounds.
专利号:US-4755606-A 优先权日:1985-05-22 标 题 :Imidazolyl-3,5-di-(diphenyl-butylsilyloxy) carboxylic acid ester intermediates 发明人:WAREING JAMES R 权利人:SANDOZ PHARMACEUTICALS CORP 摘要:Compounds of the formula and the pharmaceutically acceptable acid addition salts thereof, wherein the various substituents are defined herein below, the use thereof for inhibiting cholesterol biosynthesis and lowering the blood cholesterol level and, therefore, in the treatment of hyperlipoproteinemia and atherosclerosis, pharmaceutical compositions comprising such compounds and processes for and intermediates in the synthesis of such compounds.
专利号:EP-3793972-A1 优先权日:2018-05-15 标题 :Total synthesis of prostaglandin j natural products by stereoretentive metathesis
[参考文献]: H A J Govers, Et Al. Dissolved Organic Carbon--Contaminant Interaction Descriptors Found By 3D Force Field Calculations. Sar Qsar Environ Res. 2002 Mar;13(2):271-80. [参考文献]: M W Kennedy, Et Al. Metabolism Of Dichlorobiphenyls By Hepatic Microsomal Cytochrome P-450. Biochem Pharmacol. 1981 Mar 15;30(6):577-88. [参考文献]: Nina P Gritsan, Et Al. A Study Of 2-Azido-3,5-Dichlorobiphenyl By Nano- And Picosecond Laser Flash Photolysis And Computational Methods. Photochem Photobiol Sci. 2005 Jan;4(1):23-32.
合成参考文献
摘要:Szabó, K. J., Science of Synthesis: Multicomponent Reactions, (2013) 2, 369. 摘要:S109 | PARCEDC | List of 7074 potential endocrine disrupting compounds (EDCs) by PARC T4.2 | DOI:10.5281/zenodo.10944198