CAS: 33237-74-0; Aprindinehcl

该化合物是一种Ib类抗心律剂,主要用于管理心血管和超子体心律不齐,其行动机制包括钠气管封闭,降低分解率和抑制心脏组织中的异常自动性.该化合物显示快速启动和中间作用期,适合急性和预防性心律不全的治疗.亚普林丁氢酸的特点是其生物利用率高,组织分布广泛,确保有效的治疗浓度.其代谢物特征有助于以可控制的副作用谱保持效力.产品通常用于口服或静脉注射管理,符合纯性和稳定性的药典标准.

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物理性质

MSDS等安全信息

欧盟法规

ECHA物质C&L通报REACH预注册

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    专利信息


    专利号:US-2014315720-A1
    优先权日:2012-10-24
    标 题 :Polysaccharide ester microspheres and methods and articles relating thereto
    发明人：FALLON DENIS G; GARRETT THOMAS S; KIZER LAWTON E; ZAZZARA KAREN L; COMBS MICHAEL T; JOHNSON RICHARD K; DEHART GARY
    权利人:CELANESE ACETATE LLC
    摘要:A method for producing a polysaccharide ester microsphere may include forming a polysaccharide ester product from a polysaccharide synthesis, wherein the polysaccharide ester product comprises a polysaccharide ester and a solvent; diluting the polysaccharide ester product, thereby yielding a polysaccharide ester dope; and forming a plurality of polysaccharide ester microspheres from the polysaccharide ester dope. Suitable polysaccharides may include, but are not limited to, starch, cellulose, hemicellulose, algenates, chitosan, and any combination thereof. Esters thereof may be organic esters (e.g., acetate and the like), inorganic esters (e.g., sulfonates and the like), or combinations thereof. Further, the solids conent of the polysaccharide ester dope, in some instances, may be greater than about 16 wt %.

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    主要参考文献


    1: Danilo P Jr. Aprindine. Am Heart J. 1979 Jan;97(1):119-24. doi: 10.1016/0002-8703(79)90122-4. 1(2):147-56. doi: 10.1093/oxfordjournals.eurheartj.a061109. 100(6 Pt 2):1055-62. doi: 10.1016/0002-8703(80)90213-6. 54(4):698. 12(5):639-41. doi: 10.1093/oxfordjournals.eurheartj.a059953.
    432:201-9. doi: 10.1111/j.1749-6632.1984.tb14521.x. 40(5-6):236-43. 53 Su Pt
    1:989-93. Japanese. 41(6):1005-24. doi: 10.1016/0002-9149(78)90853-6. 63(1):1-12. doi: 10.1253/jcj.63.1. 62(7):869-870. doi: 10.1111/ped.14204. Epub 2020 Jun 24. 32(4):637-9. doi: 10.1248/bpb.32.637. 344(3):331-6. doi: 10.1007/BF00183008. 14(2-3):276-9. doi: 10.1016/0168-8278(92)90170-t. 89(3):359-61. doi: 10.7326/0003-4819-89-3-359. 100(3):347-8. doi: 10.1016/0002-8703(80)90149-0. 47(3):676-82. doi: 10.1016/0002-9149(81)90554-3. 2(8196):689-90. doi: 10.1016/s0140-6736(80)92722-1. 341(4):347-56. doi: 10.1007/BF00180661. 143(2):229-32.

    合成参考文献


    摘要:S72 | NTUPHTW | Pharmaceutically Active Substances from National Taiwan University | DOI:10.5281/zenodo.3955664
    摘要:HANSCH,C ET AL. (1995)
    摘要:Vanhoof, P. and Clarebout, P.; British Patent 1,321,424; June 27, 1973; assigned to Manufacture de Produits Pharmaceutiques A. Christiaens, SA
    摘要:Pantlen H, Runge M, Luckmann E. [Effect of aprindine in patients with normal and pre-damaged impulse forming and excitation conducting system/First communication; Sinus node function (author's transl)]. Arzneimittelforschung. 1980;30(1):92–5.
    摘要:Pantlen H, Runge M, Luckmann E. [Effect of aprindine in patients with normal and pre-damaged impulse forming and excitation conducting system. Second communication: Conduction times (author's transl)]. Arzneimittelforschung. 1980;30(2):324–8.
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