CAS: 2937-50-0; Allyl Chloroformate

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CAS号75-44-5 光气 | CAS号107-18-6 烯丙醇 | CAS号110637-44-0 (S)-1-((烯丙氧基)羰基... | CAS号627-40-7 烯丙基甲基醚 | CAS号35466-83-2 烯丙基甲基碳酸酯 | CAS号107-18-6 烯丙醇 | CAS号557-31-3 烯丙基乙基醚 | CAS号1469-70-1 碳酸丙烯乙酯 | CAS号1524-54-5 烯丙基2,2,2-三氟乙基醚 | CAS号22768-01-0 Carbonic acid,p... | CAS号18303-03-2 prop-2-enyl N-(...

Allyl 1H-Benzo[d][1,2,3]Triazol-1-Ylcarbonate置于草酰氯,N,N-二甲基甲酰胺体系中,用 二氯甲烷 用作溶剂,化学反应生成氯甲酸烯丙酯
参考文献:羧酸合成 N-三氟甲基酰胺
标题:羧酸合成 N-三氟甲基酰胺
摘要:在生物分子,药物和农用化学品中发现的含酰胺分子在自然界中无处不在,它们的衍生化代表了氟化学的重要方法学目标.三氟甲基酰胺已成为药物化合物中常见的重要官能团.迄今为止,还没有从丰富的有机羧酸衍生物合成n-三氟甲基酰胺的策略,有机羧酸衍生物是酰胺合成的理想原料.在这里,我们报告了n的合成-三氟甲基酰胺从羧酸卤化物和酯在温和条件下通过异硫氰酸酯在氟化银存在下在室温下.通过这种策略,异硫氰酸酯用 Agf 脱硫,然后将形成的衍生物酰化以提供n-三氟甲基酰胺,包括以前无法获得的结构.该方法适用范围广,凭借两个反应伙伴的多样性和可用性,为快速生成n-三氟甲基酰胺提供了平台,并应在高级中间体的改性中找到应用.
Doi:10.1016/j.Chempr.2021.07.005

专利信息

专利号:WO-2010103857-A1
优先权日:2009-03-12
标 题 :Method for solid-phase synthesis of glycopeptide using silicon-containing protecting group and synthesis device
发明人：NISHIMURA SHIN-ICHIRO; SHIMAWAKI KEN
权利人:UNIV HOKKAIDO NAT UNIV CORP; NISHIMURA SHIN-ICHIRO; SHIMAWAKI KEN
摘要:Disclosed are a novel method for the synthesis of a glycopeptide by which glycopeptides of various types can be deprotected and excised from a resin, each under weakly acidic to weakly basic conditions, without causing the problems of the epimerization of an amino acid at the a-position and the ß-elimination of a sugar residue; a synthesis device therefor; and a synthesis intermediate to be used in synthesizing a glycopeptide. Specifically disclosed are a method for the solid-phase synthesis of a glycopeptide which comprises a step for obtaining a glycopeptide derivative wherein the N-terminus is protected, the C-terminus is immobilized to a solid phase via a silicon linker, and a reactive group carried by a sugar residue and a reactive group carried by an amino acid side chain constituting a peptide are protected by silicon-containing groups, and a step for obtaining the glycopeptide by deprotecting said glycopeptide derivative and releasing the same from the solid phase by treating the glycopeptide derivative with an agent for removing the silicon-containing groups and the silicon linker; a synthesis intermediate to be used in the step for obtaining the glycopeptide derivative in the aforesaid method; and a device for the solid-phase synthesis of a glycopeptide.

专利号:US-8748660-B2
优先权日:2012-07-09
标题:Process for the synthesis of antiepileptic drug lacosamide
发明人：MURUGAN MUTHUKRISHNAN; MUJAHID MOHAMMAD; MAJUMDAR PRASHANT PRAMOD
权利人:MURUGAN MUTHUKRISHNAN; MUJAHID MOHAMMAD; MAJUMDAR PRASHANT PRAMOD; COUNCIL SCIENT IND RES
摘要:The present invention relates to the improved and efficient process for the synthesis of antiepileptic drug Lacosamide in high enantiopurity (>98% ee) and better yield. More particularly, the present invention relates to improved and efficient, cost effective process for synthesis of desired (R) isomer of Lacosamide starting from commercially available (S)-benzyl glycidyl ether.

专利号:WO-2024182268-A1
优先权日:2023-02-27
标 题 :Liquid phase peptide support synthesis of peptides and peptidomimetics
发明人：HAN AMY
权利人:REGENERON PHARMA
摘要:The present invention provides compounds useful as support for liquid phase organic synthesis e.g., liquid phase organic synthesis of peptides and peptidomimetics. In one aspect, the present invention provides a compound having a structure of Formula (I) where R1, R2, R3, m, and n are as described herein and methods of making and using same.

专利号:US-3978084-A
优先权日:1973-12-03
标题 :Synthesis of biotin
发明人：CONFALONE PASQUALE NICHOLAS; USKOKOVIC MILAN RADOJE; PIZZOLATO GIACOMO
权利人:HOFFMANN LA ROCHE
摘要:Synthesis of biotin from 4-carbomethoxy-2-(4,5-dihydrothiophen-3(2H)-one)-valeric acid methyl ester, and thiophene intermediates in this synthesis.

专利号:US-3979396-A
优先权日:1973-12-03
标 题 :Synthesis of biotin
发明人：CONFALONE PASQUALE NICHOLAS; USKOKOVIC MILAN RADOJE; PIZZOLATO GIACOMO
权利人:HOFFMANN LA ROCHE
摘要:Synthesis of biotin from 4-carbomethoxy-2-(4,5-dihydrothiophen-3(2H)-one)-valeric acid methyl ester, and dihydrothiophene intermediates in this synthesis.

专利号:US-2003083352-A1
优先权日:2000-07-31
标 题 :Synthesis of imidazole intermediates
发明人：HELAL CHRISTOPHER J
权利人:PFIZER
摘要:The invention provides a method for synthesis of compounds of formula n n n wherein R 1 and R 19 are as defined. Compounds of formula 12 are useful as intermediates for synthesizing compounds having pharmacological activity inhibiting cdk5, cdk2, and GSK-3.