专利号:US-2003162992-A1 优先权日:2001-12-14 标 题 :Preparation of intermediates useful in the synthesis of antiviral nucleosides 发明人:WATANABE KYOICHI A; DU JINFA 摘要:The present invention is an efficient process for the manufacture of α-acyloxyacetaldehyde, a key intermediate in the synthesis of 1,3-oxathiolane and 1,3-dioxolane nucleosides.
专利号:US-5939304-A 优先权日:1997-06-05 标题:Method for synthesis of anhydrothrombin 发明人:SUZUKI TOYOAKI; HOSOKAWA KAZUYA; NAGATA MASANORI 权利人:FUJIMORI KOGYO CO 摘要:A method for a synthesis of anhydrothrombin is provided which features a short process, an easy procedure, and high yields. n The method comprises n (A) a step of causing an active serine residue site of thrombin to react with an inhibitor, n (B) a step of performing an alkali treatment at a pH of not less than 11, and n (C) a step of performing an operation of recovery, and carries out these steps sequentially in the order mentioned, and is characterized by causing at least the step of performing the operation of recovery to proceed in the presence of at least one compound selected from the group consisting of polyhydric alcohols and saccharides, and a salt or an amphoteric electrolyte.
专利号:US-8105809-B2 优先权日:2008-07-03 标题 :Enzymatic synthesis of acetoacetate esters and derivatives 发明人:HENDERSON SAMUEL T 权利人:HENDERSON SAMUEL T; ACCERA INC 摘要:In one embodiment, the present invention includes a method for the synthesis of an ester derivative of acetoacetate. The method includes providing a first ester of acetoacetate and providing an alcohol. The method further includes combining the first ester of acetoacetate and the alcohol in the presence of an enzyme capable of transesterification in a non-aqueous solvent to form the ester derivative of acetoacetate. The method results in the formation of the ester derivative of acetoacetate, which, in one embodiment, is monoacetoacetin.
专利号:US-2003170828-A1 优先权日:2000-08-22 标 题 :Synthesis of complex carbohydrates 发明人:ZOU WEI; JENNINGS HAROLD J 摘要:A tailor-assembly approach is employed for synthesis of complex carbohydrates wherein a polysaccharide is degraded and the shorter product obtained from the degradation is subjected to enzymatic modification to add a sugar moiety. The products may be useful in the preparation of a cancer vaccine. In one example, oligosaccharides of the type Ia group B Streptococcus (GBSIa) capsular polysaccharide and multivalent sialyl Le x antigens are specifically described. GBSIa polysaccharide was depolymerized by partial Smith degradation to fragments representing asialo core repeating units. Enzymatic sialylation of these oligomers furnished GBSIa repeating units (from monomer to pentamer). Fucosylation on GlcNAc residues of GBSIa oligomers afforded oligosaccharides that carry multiple sialyl Le x epitopes.
专利号:WO-2024121087-A1 优先权日:2022-12-07 标 题 :Process for the synthesis of polyesterols by ring-opening co-polymerisation of gamma-butyrolactone with other lactones 发明人:SCHAUB THOMAS; NICOLAS MATHIEU; FALCONNET ALBAN; HASHMI A STEPHEN K; KONRADI RUPERT; RODEWALD DIETER; BRUCHMANN BERND 权利人:BASF SE 摘要:Described are a process for the synthesis of polyesterols by ring-opening co-polymerisation of γ-butyrolactone with other lactones, the use of a kit comprising one or more bases comprising an alkaline metal cation and one or more alcohols in said process, and polyesterols obtainable by said process.
专利号:US-11981938-B2 优先权日:2017-10-05 标 题 :Microorganisms and methods for the fermentation of cannabinoids 发明人:SZAMECZ BELA KRISZTIAN; VARSZEGI SZILVIA; NEMETH ATTILA; SZABO LORAND; KUMAR ABHINAV 权利人:ELESZTO GENETIKA INC 摘要:Disclosed herein are microorganism and methods that can be used for the synthesis of cannabigerolic acid (CBGA) and cannabinoids. The methods disclosed can be used to produce CBGA, Δ9-tetrahydrocannabinolic acid (THCA), cannabidiolic acid (CBDA), cannabichromenic acid (CBCA), Δ9-tetrahydrocannabinol (THC), cannabidiol (CBD), cannabichromene (CBC). Enzymes useful for the synthesis of CBGA and cannabinoids, include but are not limited to acyl activating enzyme (AAE1), polyketide synthase (PKS), olivetolic acid cyclase (OAC), prenyltransferase (PT), THCA synthase (THCAS), CBDA synthase (CBDAS), CBCA synthase (CBCAS), HMG-Co reductase (HMG1), and/or farnesyl pyrophosphate synthetase (ERG20). The microorganisms can also have one or more genes disrupted, such as gene that that controls beta oxidation of long chain fatty acids.
参考文献:10.1007/bf00420914 摘要:Devamanoharan PS, Varma SD. Studies on L-threose as substrate for aldose reductase: A possible role in preventing protein glycation. Molecular and Cellular Biochemistry. 1996 Sep;159(2):123–7. doi: 10.1007/bf00420914. 参考文献:10.1248/cpb.50.501 摘要:Ishikawa T, Kudo M, Kitajima J. Water-soluble constituents of dill. Chem Pharm Bull (Tokyo). 2002 Apr;50(4):501–7. doi: 10.1248/cpb.50.501. 参考文献:10.1002/rcm.2574 摘要:Santos LS, Dalmázio I, Eberlin MN, Claeys M, Augusti R. Mimicking the atmospheric OH-radical-mediated photooxidation of isoprene: formation of cloud-condensation nuclei polyols monitored by electrospray ionization mass spectrometry. Rapid Commun Mass Spectrom. 2006;20(14):2104–8. doi: 10.1002/rcm.2574. 参考文献:10.1186/s12870-017-0985-7 摘要:Lin Z, Zhang X, Wang Z, Jiang Y, Liu Z, Alexander D, Li G, Wang S, Ding Y. Metabolomic analysis of pathways related to rice grain chalkiness by a notched-belly mutant with high occurrence of white-belly grains. BMC Plant Biology. 2017 Feb 07;17(1):39. doi: 10.1186/s12870-017-0985-7. 参考文献:10.1186/s12870-018-1291-8 摘要:Fan W, Ge G, Liu Y, Wang W, Liu L, Jia Y. Proteomics integrated with metabolomics: analysis of the internal causes of nutrient changes in alfalfa at different growth stages. BMC Plant Biology. 2018 May 04;18(1):78. doi: 10.1186/s12870-018-1291-8.