CAS: 2239-64-7; 2'-Deoxy-6-Thioinosine

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6-Chloro-9-(2-deoxy-3,5-di-O-p-toluoyl-β-D-erythro-pentofuranosyl)purine Acetic acid (2R,3S,5R)-2-acetoxymethyl-5-(6-thioxo-1,6-dihydro-purin-9-yl)-tetrahydro-furan-3-yl ester 6H-purine-6-thione 2-deoxyinosine 9-{(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-1,9-dihydro-purine-6-thione (2R,3S,5R)-5-[6-(2,4-Dinitro-phenylsulfanyl)-purin-9-yl]-2-hydroxymethyl-tetrahydro-furan-3-ol S-methylthiodeoxyinosine 3-(9-{(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-9H-purin-6-ylsulfanyl)-propionitrile

📜2'-脱氧肌苷置于sodium Hydroxide,硫代乙酸,2-氯苯基二氯膦体系中,用 1,4-二氧六环,水 用作溶剂,化学反应生成6-巯基嘌呤-2-脱氧核苷
参考文献:含6-巯基嘌呤的寡脱氧核苷酸的合成及双链稳定性
标题:含6-巯基嘌呤的寡脱氧核苷酸的合成及双链稳定性
摘要:描述了将2'-脱氧肌苷转化为6-硫代-2'-脱氧肌苷(III)和制备s-保护的6-巯基嘌呤亚磷酰胺(vi)的简单程序.将单体(vi)掺入dna低聚物中,并转化成含有6-巯基嘌呤和其他在6-位修饰的嘌呤的寡聚物.含有6-巯基嘌呤或6-硫鸟嘌呤的dna双链体的解链温度(tm)的测量结果表明,两者都优先与胱氨酸而不是与胸腺嘧啶配对,但是s的存在通常会使dna双链体不稳定.
Doi:10.1016/0040-4039(92)89045-E

专利信息

专利号:US-5780617-A
优先权日:1990-05-29
标题 :Synthesis of liponucleotides
发明人：VAN DEN BOSCH HENK; VAN WIJK GYSBERT M T; KUMAR RAJ; HOSTETLER KARL Y
权利人:NEXSTAR PHARMACEUTICALS INC
摘要:A process for the preparation of glycerol di- or triphosphate derivatives comprising coupling the phosphate group of a glycerol monophosphate derivative in which one of the phosphate hydroxyls is replaced by a leaving group, with the terminal phosphate group of a mono- or diphosphate compound or a salt thereof, in the presence of a basic catalyst, under anhydrous conditions.

专利号:WO-9118914-A1
优先权日:1990-05-29
标题:Synthesis of glycerol di- and triphosphate derivatives
发明人：VEN DEN BOSCH HENK; VAN WIJK BERT; KUMAR RAJ; HOSTETLER KARL Y
权利人:VICAL INC
摘要:A process for the preparation of glycerophospholipid derivatives comprising coupling the phosphate group of a glycerol monophosphate derivative in which one of the phosphate hydroxyls is replaced by a leaving group, with the terminal phosphate group of a mono- or diphosphate compound or a salt thereof, in the presence of a basic catalyst, under anhydrous conditions.

专利号:US-8759034-B2
优先权日:2009-12-22
标 题 :Thermostable biocatalyst combination for nucleoside synthesis
发明人：MONTILLA AREVALO RAFAEL; DERONCELÉTHOMAS VICTOR MANUEL; LÓPEZ GÓMEZ CRISTINA; PASCUAL GILABERT MARTA; ESTEVEZ COMPANY CARLOS; CASTELLS BOLIART JOSEP
权利人:PLASMIA BIOTECH S L
摘要:A recombinant expression vector comprising: a) the sequence encoding a purine nucleoside phosphorylase (PNPase, E. C. 2.4.2.1), b) the sequence encoding a uridine phosphorylase (UPase, E. C. 2.4.2.3), c) or both; each of the sequences operably linked to one or more control sequences that direct the production of said phosphorylases in a suitable expression host; said sequences originating from the Archaea Thermoprotei class, characterized in that the PNPase is from Sulfolobus solfataricus (SEQ ID NO. 7) and the UPase is from Aeropyrum pernix (SEQ ID NO. 8). In addition, the present invention relates to A transglycosylation method between a sugar-donating nucleoside and an acceptor base in the presence of phosphate ions, characterized in that said method comprises the use of a uridine phosphorylase (UPase) of Aeropyrum pernix (NC_000854.2), a purine nucleoside phosphorylase (PNpase) of Sulfolobus solfataricus (NC_002754.1), or a combination thereof.

专利号:WO-0026406-A1
优先权日:1998-11-04
标题:METHOD FOR INDEXING AND DETERMINING THE RELATIVE CONCENTRATION OF EXPRESSED MESSENGER RNAs
发明人：HASEL KARL W; HILBUSH BRIAN S
权利人:DIGITAL GENE TECH INC
摘要:An improved method for the simultaneous sequence-specific identification of mRNAs in a mRNA population allows the visualization of nearly every mRNA expressed by a tissue as a distinct band on a gel whose intensity corresponds roughly to the concentration of the mRNA. In general, the method comprises the formation of cDNA using anchor primers to fix a 3'-endpoint, producing cloned inserts from the cDNA in a vector containing a bacteriophage-specific promoter for subsequent RNA synthesis, generating linearized fragments of the cloned inserts, preparing cRNA, transcribing cDNA from the cRNA and performing two sequence specific PCR amplifications of the cDNA. In preferred embodiments, the method comprises comparing the length and at least part of the nucleotide sequence of the PCR products to expected values determined from a database of nucleotide sequences. The method can identify changes in expression of mRNA associated with the administration of drugs or with physiological or pathological conditions. Also provided are vectors and primers useful for the practice of the improved method.

专利号:EP-0531452-A1
优先权日:1990-05-29
标 题 :Synthesis of glycerol di- and triphosphate derivatives

专利号:RU-2569110-C2
优先权日:2009-12-22
标题:Combination of thermo stable biocatalysts for synthesis of nucleosides