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专利信息

专利号:US-3846399-A
优先权日:1969-04-10
标题:Process for controlled stepwise synthesis of polypeptides
发明人：HIRSCHMANN R; DENKEWALTER R
权利人:MERCK & CO INC
摘要:The invention disclosed herein relates to a novel process for the controlled, stepwise synthesis of polypeptides and proteins. More particularly, it is concerned with a process for the rapid and efficient preparation of polypeptides in which multiple sequential steps are carried out without isolation of intermediate peptides. This process for the controlled stepwise synthesis of polypeptides involves reacting a starting amino acid or peptide (or derivative thereof) with an N-carboxy amino acid anhydride (or derivative thereof) in an aqueous medium under conditions of controlled pH such that the only amino group present in appreciable concentration in reactive form during the course of the reaction is the amino group in the starting amino acid or peptide.

专利号:DE-1543767-A1
优先权日:1965-07-02
标 题:Process for the controlled synthesis of polypeptides

专利号:CN-115819757-B
优先权日:2022-09-27
标题 :A kind of atypical luminescent compound containing amide group and its synthesis method

专利号:CN-118772397-A
优先权日:2023-04-04
标 题 :Synthesis method of poly-L-alanine with high polymerization degree