CAS: 2140-79-6; (2R,3R,4R,5R)-5-(6-Amino-9H-Purin-9-yl)-2-(Hydroxymethyl)-4-Methoxytetrahydrofuran-3-Ol

相似化合物

58-61-7 7387-57-7 5536-17-4

上下游产品

diazomethane adenosine trimethyl phosphite trimethylsulphonium hydroxide 2'-O-Methyladenosin 5'-phosphat (2R,3R,4R,5R)-2-Hydroxymethyl-5-(6-imino-1-methyl-1,6-dihydro-purin-9-yl)-4-methoxy-tetrahydro-furan-3-ol 6,O2'-methyladenosineN6,O2'-methyladenosine 2'-O,3'-O-dimethyladenosine

N6-甲基-2'-O-甲基腺苷置于manganese(Iv) Oxide,C17H20N4O9P(1-)*na(1+),氧气体系中,用 水,乙腈 用作溶剂,20.0 °C,101.33 Kpa 条件下,反应 7.0H,以78%的收率获得2'-O-甲基腺苷
参考文献:黄素单核苷酸作为细胞活性人工 N6-甲基腺苷 Rna 脱甲基酶的鉴定.
标题:黄素单核苷酸作为细胞活性人工 N6-甲基腺苷 Rna 脱甲基酶的鉴定.
摘要:N 6 ‐甲基腺苷 (M 6 A) 是真核 Rna 中一种常见且高度动态的修饰,可影响各种细胞通路.天然双加氧酶如 Fto 和 Alkbh5 是使mrna 中的m 6 A 残基去甲基化的酶.在本文中,首次鉴定了一种具有人工 M 6 A 脱甲基酶功能的小分子调节剂.黄素单核苷酸 (Fmn) 是核黄素激酶产生的代谢物,可介导活细胞中 Rna的 M 6 A 残基的大量光化学去甲基化.该研究为理解 M 6的去甲基化提供了新的视角mrna 中的 A 残基,揭示了强大的小分子作为 Rna 脱甲基酶和用于 Rna 生物学的新探针的开发.
Doi:10.1002/anie.201900901

专利信息

专利号:US-10167308-B2
优先权日:2013-09-14
标题:Highly efficient synthesis of long RNA using reverse direction approach
发明人：SRIVASTAVA SURESH C; SRIVASTAVA NAVEEN P
权利人:CHEMGENES CORP
摘要:The present invention relates to novel process of reverse 5′→3′ directed synthesis of RNA oligomers in the range of about 100-mer to about 200-mer has been developed and disclosed. Using that method demonstrated high quality RNA synthesis with coupling efficiency approaching 99%.

专利号:EP-1108724-B1
优先权日:1996-01-16
标题 :Synthesis of methoxy nucleosides and enzymatic nucleic acid molecules
发明人：WINCOTT FRANCINE; BEIGELMANN LEONID; MATULIC-ADAMIC JASENKA; USMAN NASSIM; HAEBERLI PETER; KARPEISKY ALEXANDER; SWEEDLER DAVID; JARVIS THALE; DIRENZO ANTHONY
权利人:SIRNA THERAPEUTICS INC
摘要:This invention relates to chemical synthesis of 2'-O-methyl, 3'-O-methyl and 5'-O-methyl nucleosides, incorporation of novel chemical modifications in enzymatic nucleic acid molecules and improved methods for the synthesis of enzymatic nucleic acid molecules.

专利号:US-11858953-B2
优先权日:2018-04-04
标 题:Compositions and methods for synthesis of phosphorylated molecules
发明人：CHAPUT JOHN; LIAO JEN-YU; BALA SAIKAT
权利人:UNIV CALIFORNIA
摘要:The invention provides compositions and methods for synthesis of phosphorylated organic compounds, including nucleoside triphosphates.

专利号:US-7820810-B2
优先权日:2007-03-19
标 题 :Process for the synthesis of 2′-O-substituted purine nulceosides
发明人：RAVIKUMAR VASULINGA
权利人:ISIS PHARMACEUTICALS INC
摘要:The present invention provides an improved process for the synthesis of 2′-O-substituted purine nucleosides. The process includes anhydro or thioanhydro ring opening of a selected 8,2′-cyclopurine nucleoside with a weak nucleophile in the presence of a Lewis acid ester, followed by reduction to afford the desired 2′-O-substituted purine nucleoside.

专利号:US-7777023-B2
优先权日:1998-10-23
标题 :Method for the chemical synthesis of oligonucleotides
发明人：VARGEESE CHANDRA; SHAFFER CHRISTOPHER; WANG WEIMIN
权利人:SIRNA THERAPEUTICS INC
摘要:The present invention features novel compositions, linkers, derivatized solid supports, and methods for the efficient solid phase synthesis of oligonucleotides, including RNA, DNA, RNA-DNA chimeras, and analogs thereof.

专利号:US-7205399-B1
优先权日:2001-07-06
标 题 :Methods and reagents for oligonucleotide synthesis
发明人：VARGEESE CHANDRA; WANG WEIMIN
权利人:SIRNA THERAPEUTICS INC
摘要:The present invention features novel compositions, linkers, derivatized solid supports, and methods for the efficient solid phase synthesis of oligonucleotides, including RNA, DNA, RNA-DNA chimeras, and analogs thereof.