CAS: 2114-02-5; Guanylthiourea

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CAS号14890-16-5 copper(II) dicy... | CAS号463-71-8 硫光气 | CAS号10026-13-8 五氯化磷 | CAS号7732-18-5 水 | CAS号2507-81-5 Guanidine, (4-p... | CAS号34885-41-1 Bis(tributylsta... | CAS号5035-65-4 Stannane, tribu... | CAS号681-99-2 三丁基锡乙氰酸酯 | CAS号100599-91-5 4-甲基噻唑-2-基鸟嘌呤盐酸盐 | CAS号34283-30-2 1,2,4-噻二唑-3,5-二胺 | CAS号113-00-8 guanidine | CAS号7120-01-6 2-(Diaminomethy... | CAS号69014-12-6 1-(4-氯甲基-2-噻唑基)胍盐酸盐

二聚氰胺置于硫化氢,水体系中,化学反应生成脒基硫脲
参考文献:Slotta; Tschesche,Chemische Berichte,1929,Vol. 62,P. 1394
标题:Slotta; Tschesche,Chemische Berichte,1929,Vol. 62,P. 1394

专利信息

专利号:US-5856500-A
优先权日:1997-03-11
标题:Synthesis of thiazole derivatives
发明人：MATTHEWS MICHAEL D; MALCOLM ARCELIO J
权利人:ALBEMARLE CORP
摘要:N- 4-(Cyanoethylthiomethyl)-2-thiazolyl!guanidine, is prepared by (a) mixing 1,3-dihaloacetone and 2-imino-4-thiobiuret in a suitable polar organic solvent at initial temperatures of about -10° to about 25° C., and agitating the mixture at about -10° to about 60° C. for at least about 1 hour; (b) heating the resultant mixture at about 40° to about 60° C. for at least about 0.5 hour; (c) mixing with the mixture from (b), thiourea and then water at about 40° to about 60° C. for a period of at least about 1 hour; (d) removing liquid polar solvent from the mixture of (c); and (e) mixing with the mixture from (d), 3-halopropionitrile and water-soluble alcohol, ether, or ether-alcohol, followed by aqueous alkali metal hydroxide while maintaining the temperature at below about 20° C., to form N- 4-(cyanoethylthiomethyl)-2-thiazolyl!guanidine. The process avoids isolating and purifying any of the intermediates, and can be conducted in the same vessel, as a 'one-pot' synthesis.

专利号:US-5856501-A
优先权日:1997-03-11
标题 :Synthesis of thiazole derivatives
发明人：MALCOLM ARCELIO J; WU TSE-CHONG
权利人:ALBEMARLE CORP
摘要:N- 4-(cyanoethylthiomethyl)-2-thiazolyl!guanidine--a key intermediate for preparing the pharmaceutical, famotidine--is produced by mixing in a liquid medium formed from a chemically indifferent organic solvent and water, and under an inert atmosphere, (i) a 2-guanidino-4-halomethylthiazole or a hydrohalide complex thereof, (ii) an S-(2-cyanoethyl)isothiourea or a hydrohalide complex thereof, and (iii) a strong alkali metal base. In lieu of (ii), an alkali metal salt of 2-cyanoethyl-1-thiol can be used, and in such case use of (iii) is optional, but preferable.

专利号:US-4656291-A
优先权日:1985-03-15
标 题 :Process for producing amidine sulfonic acids
发明人：MARYANOFF CYNTHIA A; PLAMPIN JAMES N; STANZIONE ROBIN C
权利人:MCNEILAB INC
摘要:An efficient synthesis of quanidines, e.g. of the formula (III), by oxidizing a thiourea, e.g. of the following formula (II): with H2O2 and a molybdenum catalyst to yield an aminoiminomethane sulfonic acid which can then be reacted with an amine followed by optional transamination steps.

专利号:US-4781866-A
优先权日:1985-03-15
标题 :Process for producing amidine sulfonic acid intermediates for guanidines
发明人：MARYANOFF CYNTHIA A; PLAMPIN JAMES N; STANZIONE ROBIN C
权利人:MCNEILAB INC
摘要:An efficient synthesis of quanidines, e.g. of the formula (III), by oxidizing a thiourea, e.g. of the following formula (II): with H2O2 and a molybdenum catalyst to yield an aminoiminomethane sulfonic acid which can then be reacted with an amine followed by optional transamination steps.

专利号:WO-9840367-A1
优先权日:1997-03-11
标题:Novel thiazole derivatives and their preparation
发明人：RAMACHANDRAN VENKATARAMAN; MALCOLM ARCELIO J
权利人:ALBEMARLE CORP
摘要:1-(4-Bromomethyl-2-thiazolyl)guanidine, and its acid addition salts, especially 1-(4-bromomethyl-2-thiazolyl)guanidine hydrobromide are novel compounds useful as starting materials for the synthesis of famotidine. These compounds can be produced without need for prolonged reaction periods at extremely low temperatures by mixing 1,3-dibromoacetone and 2-imino-4-thiobiuret in a suitable reaction medium. Moreover, the novel compounds can be selectively synthesized in good yield and purity from a raw material containing a combination of structurally similar analogs of 1,3-dibromoacetone.

专利号:US-4851094-A
优先权日:1985-03-15
标 题:Process for producing amidine sulfonic acid intermediates for guanidines
发明人：MARYANOFF CYNTHIA A; PLAMPIN JAMES N; STANZIONE ROBIN C
权利人:MCNEILAB INC
摘要:An efficient synthesis of quanidines, e.g. of the formula (III), by oxidizing a thiourea, e.g. of the following formula (II): (III) (II) with H2O2 and a molybdenum catalyst to yield an aminoiminomethane sulfonic acid which can then be reacted with an amine followed by optional transamination steps.