CAS: 1679-76-1; Drofenine

该化合物是能够抑制作为身体炎症和疼痛媒介的异丙胺合成;Drofenine通常用多种配方施用,包括药片和注射,而且经常为关节炎和其他炎症等条件开具处方;其药理学特征包括相对快速的行动开始,尽管其影响的持续时间可能因配方和个别患者因素而不同;与许多非典药物一样,潜在副作用可能包括胃肠不适,心血管风险和肾损伤,因此需要仔细考虑病人历史和同时服用的药物;

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MSDS等安全信息

    上下游产品

    α-环己基苯乙酸 2-Cyclohexyl-2-Phenylacetic Acid 05/09/3894

    合成工艺路线路线简述

      📜Alkaline Earth Salt Of/the/ Methylsulfuric Acid置于溶剂黄146,铂体系中,化学反应生成Alpha-环己基-苯乙酸 2-(二乙基氨基)乙基酯
      参考文献:überdie Darstellung Einiger承租人ester替代essigsäuren
      标题:überdie Darstellung Einiger承租人ester替代essigsäuren
      摘要:
      Doi:10.1002/hlca.19410240162

      海关参考信息

      专利信息


      专利号:US-7993390-B2
      优先权日:2002-02-08
      标 题:Implantable or insertable medical device resistant to microbial growth and biofilm formation
      发明人:MILLER KATHLEEN M; BUCAY-COUTO WEENNA; LI JIANMIN
      权利人:BOSTON SCIENT SCIMED INC
      摘要:Disclosed are implantable or insertable medical devices that provide resistance to microbial growth on and in the environment of the device and resistance to microbial adhesion and biofilm formation on the device. In particular, the invention discloses implantable or insertable medical devices that comprise at least one biocompatible matrix polymer region, an antimicrobial agent for providing resistance to microbial growth and/or a microbial adhesion/biofilm synthesis inhibitor for inhibiting the attachment of microbes and the synthesis and accumulation of biofilm on the surface of the medical device. Also disclosed are methods of manufacturing such devices under conditions that substantially prevent preferential partitioning of any of said bioactive agents to a surface of the biocompatible matrix polymer and substantially prevent chemical modification of said bioactive agents.

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      品牌试剂参考报价(招募中)

      📌 第三方产品分析报告

      ✅ COA系统入驻 | 共享模式

      主要参考文献


      1: Deering-Rice CE, Mitchell VK, Romero EG, Abdel Aziz MH, Ryskamp DA, Križaj D, Gopal VR, Reilly CA. Drofenine: A 2-APB Analogue with Greater Selectivity for Human TRPV3. Pharmacol Res Perspect. 2014 Oct;2(5):e00062.
      2: Bodur E, Cokuğraş AN, Tezcan EF. Inhibition effects of benactyzine and drofenine on human serum butyrylcholinesterase. Arch Biochem Biophys. 2001 Feb 1;386(1):25-9.
      4: Facchini G, Zaccheo F, Nannetti M. Simultaneous determination of hydrochloride salts of adiphenine, diphenhydramine, ethyldiphenacetate, drofenine and promazine by ion-pair HPLC. Boll Chim Farm. 1983 Aug;122(8):405-11.

      合成参考文献


      摘要:S72 | NTUPHTW | Pharmaceutically Active Substances from National Taiwan University | DOI:10.5281/zenodo.3955664
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