专利号:WO-2025109557-A1 优先权日:2023-11-24 标题:Process for the synthesis of monoesters of ethylenediaminetetraacetic acid 发明人:TERAZONO YUICHI 权利人:NUTRIEN AG SOLUTIONS CANADA INC 摘要:A process for the synthesis of a compound of Formula (I) is provided. (I) wherein R is selected from the group consisting of alkyl, alkenyl, alkynyl, and steroidyl. The process comprises reacting a compound of Formula (IIa), Formula (IIb) or a mixture thereof with a compound of Formula R-X, to obtain a compound of Formula (IIIa), a compound of Formula (IIIb) or a mixture thereof, wherein A+ is a cesium cation, a quaternary ammonium cation or a quaternary phosphonium cation, and X is a leaving group; and reacting the compound of Formula (IIIa), compound of Formula (IIIb) or mixture thereof with an acid to obtain a reaction product which comprises the compound of Formula (I). (IIa) (IIb) (IIIa) (IIIb)
专利号:US-8735391-B2 优先权日:2008-09-26 标 题 :Synthesis of functionalized octahydro-isoquinolin-1-one-8-carboxamides, octahydro-isoquinolin-1-one-8-carboxylic esters and analogs, and therapeutic methods 发明人:AUBE JEFFREY; ROTH BRYAN L; GHOSH PARTHA; FRANKOWSKI KEVIN J 权利人:AUBE JEFFREY; ROTH BRYAN L; GHOSH PARTHA; FRANKOWSKI KEVIN J; UNIV KANSAS 摘要:A functionalized polycyclic compound can have a structure of Formula 1 or salt, prodrug, analog, or derivative thereof, which compound can be prepared by providing a diene; reacting the diene with a dienophile under sufficient conditions for a combined Diels-Alder/acylation reaction so as to provide a polycyclic compound having a carboxylic acid; and coupling the carboxylic acid with an amine-containing compound or a hydroxyl-containing compound so as to form an amide or an ester and producing a compound having a structure of Formula 1. The compound can be used for modulating an opioid receptor, which can be conducted by administering to an opioid receptor a functionalized polycyclic compound as described herein in an effective amount to modulate the functionality of the opioid receptor. Such opioid modulation can provide a biological benefit to a subject.
专利号:US-2008021209-A1 优先权日:2006-06-01 标题:Ethers of bisanhydrohexitols 发明人:EAST ANTHONY; JAFFE MICHAEL; ZHANG YI; CATALANI LUIZ H 权利人:NEW JERSEY TECH INST 摘要:A novel method for the synthesis of ethers of anhydrosugars, such as isosorbide, isomannide, and isoidide, is disclosed. The bisglycidyl ethers are useful as substitutes for bisphenol A in the manufacture of thermoset epoxy ethers. Anhydrosugar ethers are derived from renewable sources and are not xenoestrogenic. Higher alkyl and aralkyl ethers are stable high-boiling oils that are good plasticizers for materials such as PVC.
专利号:US-5714649-A 优先权日:1993-07-20 标题 :1-Halo-cis-3-tetradecenes and processes for the preparation of cis-Olefin compounds by using same 发明人:FUKUMOTO TAKEHIKO; IWAI DAISUKE; OKANO SHIGEO; SUZUKI HIROSHI; OSHIMA MITSUYOSHI 权利人:SHINETSU CHEMICAL CO 摘要:Disclosed are compounds suitable for use as raw materials which enable cis-olefin compounds useful as physiologically active substances such as the sex pheromones of various insects, or as intermediates for the synthesis thereof to be prepared on an industrial scale at a reasonable cost, and processes for the preparation of cis-olefin compounds by using the same. For this purpose, novel compounds (i.e., 1-halo-cis-3-tetradecenes) of the general formula (I) CH3(CH2)9CH=CH(CH2)2X(I)wherein X is a halogen atom, are used as raw materials for the preparation of cis-olefin compounds.
专利号:CN-104470547-B 优先权日:2012-05-24 标题 :Utilize the method for tubular article synthesis of radiopharmaceuticals
专利号:US-2014243333-A1 优先权日:2008-09-26 标题:Synthesis of functionalized octahydro-isoquinolin-1-one-8-carboxylic esters and analogs, and therapeutic methods