📜亞乙二(胺甲酸乙酯)置于水,氯体系中,化学反应生成N,N-二氯氨基甲酸乙酯 参考文献:Datta; Gupta,Journal Of The American Chemical Society,1915,Vol. 37,P. 580 标题:Datta; Gupta,Journal Of The American Chemical Society,1915,Vol. 37,P. 580
专利号:US-4293495-A 优先权日:1980-04-07 标 题:Symmetrical azetidinone aldehyde disulfides and process 发明人:KUKOLJA STJEPAN; PFEIL JANICE L 权利人:LILLY CO ELI 摘要:4R,4'R bis[1-(2-N-3-methyl-4-al-Z-but-2-ene-oate)-2-oxo-3S-acylamino azetidine]disulfide compounds are prepared by reacting the corresponding 7α-acylamino-2α-alkoxy-3-methyl-3-cephem-4-carboxylates first with an N-chloro halogenating agent, e.g., N-chlorosuccinimide, then with an aqueous suspension of mercury dichloride and cadmium carbonate. The disulfide compounds produced in this invention are intermediates in the synthesis of the biologically active 7β-acylamino-7α-alkoxy-3-methyl 1-oxa β-lactam antibiotic compounds.
专利号:US-3983134-A 优先权日:1974-08-05 标 题 :Ureylenethiophanes and their related compounds, and production thereof 发明人:MATSUI MASANAO; MORI KENJI; KITAHARA TAKESHI; KITAMURA SEIICHI; OHBA KAZUMASA 权利人:TEIKOKU CHEM IND CO LTD 摘要:Ureylenethiophanes and their related compounds of the formula: ##SPC1## n Having a cis-configuration on the ureylene or thioureylene juncture, which are useful as the intermediates in the synthesis of biologically active biotin and its related compounds, can be produced selectively by reacting the corresponding compounds of the formula: ##SPC2## n With isocyanates or isothiocyanates wherein R is a hydrogen atom, an alkyl group or an aralkyl group, R 1 and R 2 are each a hydrogen atom or an aliphatic hydrocarbon group bearing or not a carboxyl group or any other group convertible thereto at the terminal position, X is a halogen atom, Y is an oxygen atom or a sulfur atom and Z is an oxygen atom, a sulfur atom, a sulfinyl group or a sulfonyl group.
专利号:US-4394313-A 优先权日:1980-04-07 标题:Symmetrical azetidinone aldehyde disulfides and process 发明人:KUKOLJA STJEPAN; PFEIL JANICE L 权利人:LILLY CO ELI 摘要:4R, 4'R bis [1-(2-N-3-methyl-4-al-Z-but-2-ene-oate)-2-oxo-3S-acylamino azetidine]disulfide compounds are prepared by reacting the corresponding 7α-acylamino-2α-alkoxy-3-methyl-3-cephem-4-carboxylates first with an N-chloro halogenating agent, e.g., N-chlorosuccinimide, then with an aqueous suspension of mercury dichloride and cadmium carbonate. The disulfide compounds produced in this invention are intermediates in the synthesis of the biologically active 7β-acyl-amino-7α-alkoxy-3-methyl 1-oxa β-lactam antibiotic compounds.
专利号:GB-1584105-A 优先权日:1976-06-16 标 题:Synthesis of azetidinones
参考文献:10.1007/s11746-997-0206-x 摘要:Naqvi F, Rauf A, Siddiqui MM, Ahmad MS, Osman SM. Pseudohalogenation of methyl 9‐hydroxy‐cis‐12‐and 12‐hydroxy‐cis‐9‐octadecenoate. J Americ Oil Chem Soc. 1997 Jun;74(6):713–7. doi: 10.1007/s11746-997-0206-x. 参考文献:10.1007/bf02636068 摘要:Lie Ken Jie MSF, Syed‐Rahmatullah MSK. Synthesis and spectroscopic properties of long‐chain aza, aziridine and azetidine fatty esters. J Americ Oil Chem Soc. 1992 Apr;69(4):359–62. doi: 10.1007/bf02636068.