CAS: 120202-71-3; (R)-Methyl 2-(2-Chlorophenyl)-2-(6,7-Dihydrothieno[3,2-C]Pyridin-5(4H)-yl)Acetate Sulfate

英文名称(R)-Methyl 2-(2-Chlorophenyl)-2-(6,7-Dihydrothieno[3,2-C]Pyridin-5(4H)-yl)Acetate Sulfate
中文名称(R)-硫酸氢氯吡格雷
IUPAC名称methyl (R)-2-(2-chlorophenyl)-2-(6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)acetate sulfate
其它别名Clopidogrel Ep Imp C; Clopidogrel Impurity 5/clopidogrel Ep Impurity C Sulfate/(R)-Clopidogrel Sulfate/methyl (-)-(R)-(O-Chlorophenyl)[6,7-Dihydrothieno[3,2-C]Pyridine-5(4H)-Yl]Acetate Hydrogen Sulfate; Clopidogrel Hydrogen Sulfate Impurity C; Clopidogrel Ep Impurity C Sulfate; Clopidogrel Ep Impurity C Sulfate ((R)-Clopidogrel Sulfate); (R)-Methyl 2-(2-Chlorophenyl)-2-(6,7-Dihydrothieno[3,2-C]Pyridin-5(4H)-yl)Acetate Sulfate; (R)-Methyl (2-Chlorophenyl)(6,7-Dihydro-4H-Thieno[3,2-C]Pyridin-5-yl)Acetate Hydrogensulfate; Clopidogrel Impurity C
CAS编号120202-71-3
MFCD编号:MFCD17215518
EINECS号:601-681-2
FDA UNII编号:39KXS67R6V
分子式:C16H18ClNO6S2
分子量:419.89
产品CID: 268460
产品分类分析化学 → 标准品 → 药典标准品和杂质标准品

相似结构搜索
InChIKey: FDEODCTUSIWGLK-XFULWGLBSA-N
FDEODCTUSIWGLK-XFULWGLBSA-N…
计算化学: 氢键受体数8.0氢键供体数2.0可旋转键数4.0

物理性质

熔点47-49°C
沸点447.3±45.0 °C at 760 mmHg
闪点224.3±28.7 °C
密度1.4±0.1 g/cm3
PSA:140.76
LogP:3.77
折射率1.658
蒸汽压0.0±1.1 mmHg at 25°C
溶解性DMSO (Slightly), Methanol (Slightly), Water (Slightly)
外观形态粉末
储存条件惰性气氛,2-8°C
产品应用该化合物用于抗血管.

MSDS等安全信息

GHS象形图
GHS符号GHS05;
注释: Corrosion
危险类别皮肤腐蚀类别1B
严重眼损伤类别1
皮肤腐蚀类别1
警示词Danger(危险)
危险描述H314 |造成严重皮肤灼伤和眼损伤.
H318 |造成严重眼损伤.
防范说明P260-P280-P303+P361+P353-P304+P340+P310-P305+P351+P338
UN编号UN 3261 8 / PGIII
危险品标志C,Xi
安全声明26-36/37/39-45
危险类别码34-41
WGK Germany3

欧盟法规

C&L通报REACH预注册

上下游产品

(S)-(+)-clopidogrel clopidogrel clopidogrel hydrogen sulfate methyl (R)-2-(2-chlorophenyl)-2-(4,5,6,7-tetrahydrothieno[3,2-c]pyridin-5-yl)acetate(S)-methyl 2-(2-bromo-6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)-2-(2-chlorophenyl)acetate clopidogrel 5-(2-chloro-1-(2-chlorophenyl)ethyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine

合成工艺路线路线简述

氯吡格雷杂质c置于硫酸体系中,用丙酮用作溶剂,化学反应生成氯吡格雷usp杂质c
参考文献: Process For The Preparation Of Clopidogrel Polymorphous Form 1 Using Seed Chrystals[fr] Procédé De Préparation De La Forme 1 Du Clopidogrel Polymorphe à L'Aide De Germes Cristallins
标题: Process For The Preparation Of Clopidogrel Polymorphous Form 1 Using Seed Chrystals[fr] Procédé De Préparation De La Forme 1 Du Clopidogrel Polymorphe à L'Aide De Germes Cristallins
摘要:该发明涉及一种制备右旋甲基-α-5-(4,5,6,7-四氢-(3,2-C)噻吩吡啶基)-(2-氯苯基)乙酸氢硫酸盐的过程,通常称为晶态形式i的氢硫酸氢氯吡格列.