CAS: 1193-71-1; 4,6-Dimethylpyridin-3-Amine

相似化合物

1074-99-3 3430-33-9 1073-21-8

上下游产品

2,4-dimethyl-5-nitropyridine 2,4-lutidine 2,4-dimethyl-3-nitropyridine 2-chloro-4-methyl-5-nitro-pyridine 2,4-dimethyl-5-hydroxypyridine H-pyrazolo[3,4-c]pyridine5-methyl-3H-pyrazolo[3,4-c]pyridine 5-acetamido-2,4-dimethylpyridine 5-bromo-2,4-dimethyl-pyridine

📜2,4-二甲基吡啶置于硫酸,Palladium 10% On Activated Carbon,氢气,Potassium Nitrate体系中,用 甲醇 用作溶剂,20.0~120.0 °C,101.33 Kpa 条件下,反应 32.0H,反应生成2,4-二甲基-5-氨基吡啶
参考文献:一系列腺苷a 3受体激动剂的合成†
标题:一系列腺苷a 3受体激动剂的合成†
摘要:一系列的1'-(6-氨基嘌呤-9-基)-1'-脱氧-N-甲基-β-D-核呋喃核糖酰胺,其特征为2-二烷基氨基-7-甲基恶唑并[4,5-B ]吡啶-已经合成了用于筛选为选择性腺苷a 3受体激动剂的感兴趣的n 6上的5-基甲基取代基.这项工作涉及与已知的1'-(6-氯嘌呤-9-基)-1'-脱氧偶联的2-二烷基氨基-5-氨基甲基-7-甲基恶唑并[4,5-B ]吡啶和类似物的合成.-ñ-甲基-β-D-Ribofuranuronamide.通过2,4-二甲基吡啶n的区域选择性官能化合成恶唑并[4,5-B ]吡啶-氧化物.发现这些反应的区域选择性取决于与2-二甲基氨基-5,7-二甲基恶唑并[4,5-B ]吡啶-N-氧化物在与三氟乙酸反应时在7-甲基上进行区域选择性官能化的杂环的性质.与4,6-二甲基-3-羟基吡啶-N-氧化物与乙酸酐的反应相反,后者导致6-甲基官能化.为了优化对a
Doi:10.1039/c6Ob00244G

专利信息

专利号:WO-9948868-A9
优先权日:1998-03-26
标 题 :Heterocyclic classes of compounds for the modulating tyrosine protein kinase
发明人：FONG ANNIE; HANNAH ALISON; HARRIS G DAVIS; HIRTH PETER; HUBBARD STEVEN R; LANGECKER PETER; LIANG CONGXIN; MCMAHON GERALD; MOHAMMADI MOOSA; SCHLESSINGER JOSEPH; SHAWVER LAURA K; SUN LI; TANG PENG C; ULLRICH AXEL
权利人:SUGEN INC; UNIV NEW YORK; MAX PLANCK INST FUR BIOCHEMIE; FONG ANNIE; HANNAH ALISON; HARRIS G DAVIS; HIRTH PETER; HUBBARD STEVEN R; LANGECKER PETER; LIANG CONGXIN; MCMAHON GERALD; MOHAMMADI MOOSA; SCHLESSINGER JOSEPH; SHAWVER LAURA K; SUN LI; TANG PENG C; ULLRICH AXEL
摘要:The invention relates to certain indolinone-based and pyrazolylamide-based compounds, their method of synthesis, and combinatorial libraries consisting of the compounds. The invention also relates to methods of modulating the function of protein kinases using these compounds and methods of treating diseases by modulating the function of protein kinases and related signal transduction pathways.