CAS: 887587-15-7; 3-Ethylamino-Pyrrolidine-1-Carboxylic Acid Tert-Butyl Ester

相似化合物

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上下游产品

CAS号75-07-0 乙醛 | CAS号147081-49-0 (R)-(+)-N-叔丁氧羰基...

📜3-氨基吡咯烷-1-羧酸叔丁酯置于palladium 10% On Activated Carbon,氢气,Sodium Hydride,N,N-二异丙基乙胺体系中,用 乙醇,二氯甲烷,N,N-二甲基甲酰胺 作为反应溶剂,20.0 °C,101.33 Kpa 条件下,反应 3.0H,反应生成 3-(乙基氨基)-1-吡咯烷甲酸叔丁酯
参考文献:Discovery Of Quinazoline-2,4(1H,3H)-Dione Derivatives As Novel Parp-1/2 Inhibitors: Design,Synthesis And Their Antitumor Activity
标题:Discovery Of Quinazoline-2,4(1H,3H)-Dione Derivatives As Novel Parp-1/2 Inhibitors: Design,Synthesis And Their Antitumor Activity
摘要:新型喹唑啉-2,4(1H,3H)-二酮衍生物,带有3-氨基吡咯烷基团,被确认为具有独特结合特性的有效parp-1/2抑制剂.
DOI:10.1039/c8Ob00286J

专利信息

专利号:US-8030501-B2
优先权日:2006-07-28
标题 :Process for producing optically active 3-amino nitrogen-containing compounds
发明人：OHNUKI MASATOSHI; IZUMIDA MASASHI; NISHIYAMA AKIRA; MATSUMOTO SHINGO
权利人:KANEKA CORP
摘要:Aiming at production of an optically active 3-amino nitrogen-containing compound which is useful as an intermediate in synthesis of medicines and pesticides, in particular, an optically active 1-protected-3-aminopyrrolidine derivative, from an inexpensive and readily available raw material by a process which is efficient and can be practiced industrially, an optically active 3-amino nitrogen-containing compound is produced by performing a reaction of an optically active 3-substituted nitrogen-containing compound with ammonia, methylamine, ethylamine or dimethylamine in the presence of water. In addition, a 1-protected-3-aminopyrrolidine derivative is produced by performing a reaction of an optically active 1-protected-3-(sulfonyloxy)pyrrolidine derivative with ammonia, methylamine, ethylamine, or dimethylamine in the presence of methanol, ethanol, n-propanol, or isopropanol under a pressure of less than 30 barr.