CAS: 69045-79-0; 2-Chloro-5-Iodopyridine

上下游产品

CAS号20511-12-0 2-氨基-5-碘吡啶 | CAS号53939-30-3 5-溴-2-氯吡啶 | CAS号504-29-0 2-氨基吡啶 | CAS号75-44-5 光气 | CAS号60154-05-4 5-碘-1-甲基吡啶-2(1H)-酮 | CAS号7647-01-0 盐酸 | CAS号470463-42-4 4-(5-碘代吡啶-2-基)吗啉 | CAS号494771-62-9 5-碘-2-(1-吡咯烷并)吡啶 | CAS号41288-96-4 2-氯-5-羟基吡啶 | CAS号444120-94-9 2-氯-5-(4,4,5,5-... | CAS号444120-91-6 6-氯吡啶-3-硼酸 | CAS号20857-44-7 2,5-双(三氟甲基)吡啶 | CAS号52334-81-3 2-氯-5-三氟甲基吡啶 | CAS号2127-03-9 2,2'-二硫二吡啶 | CAS号2637-34-5 2-巯基吡啶 | CAS号263012-63-1 2-氯-5-乙炔吡啶

5-溴-2-氯吡啶置于nbu4Znli2*tmeda,碘体系中,用 甲苯,四氢呋喃 作为反应溶剂,化学反应 5.0H,以80%的收率获得产物2-氯-5-碘吡啶
参考文献:锌酸盐的同质促进的室温卤素-溴吡啶的金属交换
标题:锌酸盐的同质促进的室温卤素-溴吡啶的金属交换
摘要:均三酸锌和四烷基锌酸锂与一组溴吡啶反应.高效和化学选择性溴-金属交换是在室温下以低于化学计算量实现ñ卜4 Znli 2 ⋅tmeda试剂(1/3当量; Tmeda = ñ,ñ,N',N'四甲基乙二胺).该反应性与t Bu 4 Znli 2的反应性相反⋅tmeda,在一个当量以下效率低下.dft计算使我们能够合理化反应中n⋅⋅⋅li稳定的聚吡啶基锌盐的形成.使用化学计量的试剂也可以实现二溴吡啶的一锅双功能化.在溴吡啶中直接形成czn键使我们能够进行有效的negishi型交叉偶联.
DOI:10.1002/chem.201001664

专利信息

专利号:US-6384228-B2
优先权日:1998-05-26
标题 :Method for synthesis of halopyridyl-azacyclopentane derivative and intermediate thereof
发明人：NODE MANABU; NAKAMURA DAISAKU; FUJIWARA TOSHIO; ICHIHASHI SHOGO
权利人:NIHON MEDIPHYSICS CO LTD
摘要:The present invention relates to a method for synthesis of an optically active halopyridyl-azacyclo-pentane derivative and the intermediate thereof which comprises preparing an optically active allene-1,3-dicarboxylic acid ester derivative from an optically active acetonedicarboxylic acid ester derivative and then proceeding through a 7-azabicyclo[2.2.1]heptane derivative to obtain the objective product.

专利号:US-7884125-B2
优先权日:2008-04-30
标 题:Straightforward entry to 7-azabicyclo[2.2.1]heptane-1-carbonitriles and subsequent synthesis of epibatidine analogues
发明人：STEVENS CHRISTIAN; HEUGEBAERT THOMAS
权利人:UNIV GENT
摘要:The present invention relates to a group of substituted-7-azabicyclo-[2.2.1]heptyl derivatives with biological activity. The present invention also relates to synthetic methods for producing said substituted-7-azabicyclo-[2.2.1]heptyl derivatives. The present invention also relates to certain intermediates for producing such substituted-7-azabicyclo-[2.2.1]heptyl derivatives, as well as a synthetic method for producing such intermediates. The present invention also relates to pharmaceutical compositions comprising such substituted-7-azabicyclo-[2.2.1]heptyl derivatives, as well as their use as medicaments for the treatment of diseases mediated by a Nicotinic Acetylcholine Receptor or a receptor being a member of the Neurotransmitter-gated Ion Channel Superfamily, such as pain, Alzheimer's disease, Parkinson's disease, schizophrenia, epilepsy and nicotine addiction.

专利号:US-5565573-A
优先权日:1993-11-12
标 题:Synthesis of epibatidine and analogs thereof
发明人：LAROCK RICHARD C
权利人:UNIV IOWA STATE RES FOUND INC
摘要:The present invention provides a method to prepare epibatidine or an analog thereof comprising reacting a bicyclic olefin or diene, such as an azanorbornene, with an aryl or heteroaryl halide or triflate in the presence of a catalytic amount of Pd(O) and a formate salt.

专利号:US-2002010339-A1
优先权日:1998-05-26
标 题:Method for synthesis of halopyridyl-acyclopentane derivative and intermediate thereof

专利号:US-7754188-B2
优先权日:2003-06-30
标 题:Radiolabeled cannabinoid-1 receptor modulators
发明人：BURNS H DONALD; CHEN ALEX M; GIBSON RAYMOND E; GOULET MARK T; HAGMANN WILLIAM K; HAMILL TERENCE G; JEWELL JAMES P; LIN LINUS S; LIU PING; PERESYPKIN ANDREY V
权利人:MERCK SHARP & DOHME
摘要:The present invention relates to particular radiolabeled Cannabinoid-1 (CB1) receptor modulators, and methods of using these modulators for labeling and diagnostic imaging of Cannabinoid-1 receptors in mammals, particularly humans. In addition, intermediates useful for the synthesis of the radiolabeled Cannabinoid-1 receptor modulators are also disclosed, as well as the processes for synthesizing the radiolabeled Cannabinoid-1 receptor modulators. Still further, formulations of the radiolabeled Cannabinoid-1 receptor compounds are described.

专利号:US-7582633-B2
优先权日:2007-01-26
标题:Azacycloalkane derivatives as inhibitors of stearoyl-coenzyme a delta-9 desaturase
发明人：LEBLANC YVES; POWELL DAVID; RAMTOHUL YEEMAN K; LEGER SERGE
权利人:MERCK FROSST CANADA L L C
摘要:Azacycloalkane derivatives of structural formula I are selective inhibitors of stearoyl-coenzyme A delta-9 desaturase (SCD1) relative to other known stearoyl-coenzyme A desaturases. The compounds of the present invention are useful for the prevention and treatment of conditions related to abnormal lipid synthesis and metabolism, including cardiovascular disease, such as atherosclerosis; obesity; diabetes; neurological disease; metabolic syndrome; insulin resistance; and liver steatosis.