CAS: 603-41-8; 4,4'-(Pyridin-2-Ylmethylene)Diphenol

上下游产品

pyridine-2-carbaldehyde phenol 4,4'-(pyridin-2-ylmethylene)dianiline di[4'',4'''-di(methoxy)phenyl](2'-pyridyl)methanolbisacodyl Guttalax

2-吡啶甲酸乙酯置于氢碘酸,Magnesium,溶剂黄146体系中,用 四氢呋喃 作为反应溶剂,化学反应 11.0H,反应生成 4,4'-(2-吡啶甲基)双酚
参考文献:一种制备匹可硫酸钠的新方法
标题:一种制备匹可硫酸钠的新方法
摘要:本发明涉及一种制备式(v)所示的匹可硫酸钠的方法,该方法包括以下步骤:(a)以式(i)所示的2‑吡啶甲酸酯为起始原料,与式(II)所示的4‑卤代苯基烷基醚发生格氏反应反应生成式(iii)所示的4',4"‑二烷氧基二苯基‑(2‑吡啶)‑甲醇(化合物iii).(b)4',4"‑二烷氧基二苯基‑(2‑吡啶)‑甲醇(化合物iii)在路易斯酸作用下脱去一分子水和烷氧基中的烷基,得到式(iv)所示的4',4"‑二羟苯基‑(2‑吡啶)‑甲烷(化合物iv).(c)4',4"‑二羟苯基‑(2‑吡啶)‑甲烷与氯磺酸发生硫酸酯化反应,用氢氧化钠后处理,得到匹可硫酸钠粗品,再通过重结晶得到高纯度的匹可硫酸钠(化合物v).本发明提供了一种与现有技术不同的匹可硫酸钠制备新方法,该方法操作简单,原子经济性高,适用于工业化生产.

专利信息

专利号:US-6451543-B1
优先权日:1998-08-31
标题:Lipid matrix-assisted chemical ligation and synthesis of membrane polypeptides
发明人：KOCHENDOERFER GERD G; HUNTER CHRISTIE L; KENT STEPHEN B H; BOTTI PAOLO
权利人:GRYPHON SCIENCES
摘要:The present invention relates to methods and compositions for lipid matrix-assisted chemical ligation and synthesis of membrane polypeptides that are incorporated in a lipid matrix. The invention is exemplified in production of a prefolded membrane polypeptide embedded within a lipid matrix via stepwise chemoselective chemical ligation of unprotected peptide segments, where at least one peptide segment is embedded in a lipid matrix. Any chemoselective reaction chemistry amenable for ligation of unprotected peptide segments can be employed. Suitable lipid matrices include liposomes, micelles, cell membrane patches and optically isotropic cubic lipidic phase matrices. Prefolded synthetic and semi-synthetic membrane polypeptides synthesized according to the methods and compositions of the invention also permit site-specific incorporation of one or more detectable moieties, such as a chromophore, which can be conveniently introduced during synthesis. The methods and compositions of the invention have multiple uses. For example, they can be used to assay ligand binding to membrane polypeptides and domains comprising a receptor, and thus are extremely useful for structure/function studies, drug screening/selection/design, and diagnostics and the like, including high-throughput applications. The methods and compositions of the invention are particularly suited for FRET analyses of previously inaccessible membrane polypeptides.

专利号:US-2016160397-A1
优先权日:2010-04-06
标 题 :Liquid silane-based compositions and methods of fabrication
发明人：BOUDJOUK PHILIP; DAI XULIANG; ELANGOVAN ARUMUGASAMY; ANDERSON KENNETH; HAN SIJIN
权利人:NDSU RES FOUNDATION
摘要:Described herein are synthesis schemes and methods for producing silicon based nanostructures and materials, including compositions and methods for synthesis of silicon-based nanowires and composites from four-component inks of a liquid silane, a polymer, an accelerant and a solvent, or from five-component inks of a liquid silane, a polymer, an accelerant, a solid phase and a solvent. The methods can be used for producing silicon based microfibers and nanofibers that can be used in a variety of applications including material composites, electronic devices, sensors, photodetectors, batteries, ultracapacitors, and photosensitive substrates.

专利号:WO-2025077495-A1
优先权日:2023-10-10
标 题 :Audio synthesis method and apparatus, audio synthesis model training method and apparatus, electronic device, computer readable storage medium, and computer program product
发明人：GU Yu; WENG CHAO
权利人:TENCENT TECH SHENZHEN CO LTD
摘要:An audio synthesis method and apparatus, an audio synthesis model training method and apparatus, an electronic device, a computer readable storage medium, and a computer program product, relating to artificial intelligence technology. The audio synthesis method comprises: on the basis of language information of a target text and preset style information, calling an audio synthesis model to execute the following processing, wherein the audio synthesis model comprises a prior encoder and a waveform decoder: by means of the prior encoder and on the basis of the language information and the preset style information, generating audio features corresponding to the target text; by means of the prior encoder, performing normalizing flow processing on the audio features to obtain hidden variables of the target text; and by means of the waveform decoder, performing waveform decoding processing on the hidden variables of the target text to obtain a waveform that conforms to an audio style described by the preset style information and corresponds to the target text.

专利号:US-9470680-B2
优先权日:2011-02-28
标 题:Fluorescence-based approach to monitor release factor-catalyzed termination of protein synthesis
发明人：GONZALEZ JR RUBEN L; STERNBERG SAMUEL H; PULUKKUNAT DILEEP K
权利人:GONZALEZ JR RUBEN L; STERNBERG SAMUEL H; PULUKKUNAT DILEEP K; UNIV COLUMBIA
摘要:Provided are probes comprising a class 1 release factor conjugated to a fluorescent label and methods of making the probes. Also provided are methods for detecting conformational changes in ribosomes and associated molecules, such as class 1 release factors. In addition, methods of identifying a compound for reducing nonsense-mediated decay of mRNA and/or for inhibiting termination of protein synthesis at a premature stop codon, are described. Methods of assaying RF3 activity are also included.

专利号:US-7482425-B2
优先权日:1999-08-26
标题:Compositions for lipid matrix-assisted chemical ligation
发明人：KOCHENDOERFER GERD G; HUNTER CHRISTIE L; KENT STEPHEN B H; BOTTI PAOLO
权利人:AMYLIN PHARMACEUTICALS INC
摘要:The present invention relates to methods and compositions for lipid matrix-assisted chemical ligation and synthesis of membrane polypeptides that are incorporated in a lipid matrix. The invention is exemplified in production of a prefolded membrane polypeptide embedded within a lipid matrix via stepwise chemoselective chemical ligation of unprotected peptide segments, where at least one peptide segment is embedded in a lipid matrix. Any chemoselective reaction chemistry amenable for ligation of unprotected peptide segments can be employed. Suitable lipid matrices include liposomes, micelles, cell membrane patches and optically isotropic cubic lipidic phase matrices. Prefolded synthetic and semi-synthetic membrane polypeptides synthesized according to the methods and compositions of the invention also permit site-specific incorporation of one or more detectable moieties, such as a chromophore, which can be conveniently introduced during synthesis. The methods and compositions of the invention have multiple uses. For example, they can be used to assay ligand binding to membrane polypeptides and domains comprising a receptor, and thus are extremely useful for structure/function studies, drug screening/selection/design, and diagnostics and the like, including high-throughput applications. The methods and compositions of the invention are particularly suited for FRET analyses of previously inaccessible membrane polypeptides.

专利号:US-9346966-B2
优先权日:2010-04-06
标 题:Liquid silane-based compositions and methods for producing silicon-based materials
发明人：SCHULZ DOUGLAS L; HOEY JUSTIN; WU XIANGFA; AKHATOV ISKANDER; BOUDJOUK PHILIP; DAI XULIANG; PEDERSON LARRY; SMITH JEREMIAH; ELANGOVAN ARUMUGASAMY; HAN SIJIN
权利人:NDSU RES FOUNDATION
摘要:Described herein are synthesis schemes and methods for producing silicon based nanostructures and materials, including compositions and methods for synthesis of silicon-based nanowires and composites from three-component and four-component liquid silane/polymer inks. Materials and methods for producing silicon based micro and nanofibers that can be used in a variety of applications including material composites, electronic devices, sensors, photodetectors, batteries, ultracapacitors, and photosensitive substrates, and the like.