3-溴吡啶-N-氧化物 反应生成 3-溴-2-氰基吡啶 参考文献:Fused Heterocyclic Succinimide Compounds And Analogs Thereof,Modulators Of Nuclear Hormone Receptor Function 标题:Fused Heterocyclic Succinimide Compounds And Analogs Thereof,Modulators Of Nuclear Hormone Receptor Function 摘要:融合的环化合物,使用这种化合物治疗与核激素受体相关的疾病,如癌症和免疫紊乱的方法,以及含有这种化合物的药物组合物.
专利号:US-2024383920-A1 优先权日:2023-04-14 标 题:Synthesis of ras inhibitors 发明人:LI SHAOLING; LL YI; LOBBEN PAUL; WANG ROSS; BALLMER STEVE; HUANG XIAOJUN 权利人:REVOLUTION MEDICINES INC 摘要:The present invention relates to Ras inhibitors and to methods for preparing Ras inhibitors.
专利号:US-8633182-B2 优先权日:2012-05-30 标题:Indanyloxyphenylcyclopropanecarboxylic acids 发明人:HAMPRECHT DIETER; FRATTINI SARA; LINGARD IAIN; PETERS STEFAN 权利人:HAMPRECHT DIETER; FRATTINI SARA; LINGARD IAIN; PETERS STEFAN; BOEHRINGER INGELHEIM INT 摘要:The present invention relates to compounds of general formula I, n nwherein the groups R 1 , R 2 , R 3 , m and n are defined as in claim 1 , which have valuable pharmacological properties, in particular bind to the GPR40 receptor and modulate its activity. The compounds are suitable for treatment and prevention of diseases which can be influenced by this receptor, such as metabolic diseases, in particular diabetes type 2. Furthermore, the invention relates to novel intermediates, useful for the synthesis of compounds of formula I.
专利号:WO-2010096722-A1 优先权日:2009-02-20 标 题 :3-oxo-2, 3-dihydro- [1,2, 4] triazolo [4, 3-a]pyridines as soluble epoxide hydrolase (seh) inhibitors 发明人:FENG JUN; KEUNG WALTER; NOTZ WOLFGANG REINHARD LUDWIG 权利人:TAKEDA PHARMACEUTICAL; FENG JUN; KEUNG WALTER; NOTZ WOLFGANG REINHARD LUDWIG 摘要:Claimed are intermediates in the synthesis of N-Arylmethyl-3-Oxo-2,3-dihydro- [1,2,4]triazolo[4,3-a]pyridine-6-carboxamides as well as a process (A) to arrive at 3-Oxo-2, 3-dihydro-[1,2,4]triazolo[4,3-a]pyridine-6-carboxylic acid. The triazolo[4,3-a]pyridine-6-carboxamides of formula (I) are used as soluble epoxide hydrolase inhibitors (sEH) having therapeutic effect in pathologic conditions such as hypertension, stroke, inflammatory processes, diabetes and a variety of cardiovascular diseases.
专利号:WO-2024216017-A2 优先权日:2023-04-14 标题:Synthesis of ras inhibitors
专利号:WO-2024216008-A1 优先权日:2023-04-14 标题 :Synthesis of ras inhibitors
专利号:TW-202442230-A 优先权日:2023-04-14 标 题 :Synthesis of ras inhibitors