CAS: 551-16-6; (2S,5R,6R)-6-Amino-3,3-Dimethyl-7-Oxo-4-Thia-1-Azabicyclo[3.2.0]Heptane-2-Carboxylic Acid

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CAS号87-08-1 青霉素V | CAS号20425-27-8 (2S,5R,6R)-6-(1... | CAS号128971-96-0 (2S,5R,6S)-Benz... | CAS号128971-92-6 (3S,4R)-3-[(ter... | CAS号128971-93-7 (3S,4R)-3-[(ter... | CAS号37091-66-0 阿洛西林 | CAS号32887-01-7 美西林 | CAS号14796-35-1 2-(2'-carboxyph... | CAS号19379-33-0 L-(+)-Ampicillin | CAS号69-53-4 氨苄西林 | CAS号2935-35-5 (|S|)-(+)-α-苯甘氨酸 | CAS号205320-24-7 (2S)-6,6-dibrom... | CAS号2315-05-1 methyl 3,3-dime... | CAS号343-55-5 双氯西林钠 | CAS号61-33-6 青霉素

Penicillin G Potassium置于sodium Hydroxide体系中,用 Aq. Phosphate Buffer 作为反应溶剂,化学反应生成 6-氨基青霉烷酸
参考文献:双功能磁性纳米花:高效的固定化青霉素g酰基转移酶的载体
标题:双功能磁性纳米花:高效的固定化青霉素g酰基转移酶的载体
摘要:通过扫描电子显微镜,透射电子显微镜(tem),振动样品表征了具有环氧基和亲水性邻苯二酚以及能够与青霉素g酰基转移酶(pga)共价偶联的邻苯二酚基的新型双功能磁性纳米花(dmnf).磁力计,N 2吸附等.研究表明,Dmnf具有纳米片的"分层花瓣"结构,比饱和磁化强度为39.7 Emu / G,平均孔径为25.4 Nm,比表面积为17.28 M 2/g.固定在dmnf上的pga催化酶负载106 Mg / G的青霉素g钾的水解,其表观活性达到2,667 U / G,这得益于磁性dmnf的"分层花瓣"和大孔结构.高酶负载和底物分子快速扩散到固定的pga上反应.重复使用10个循环后,固定化pga的表观活性可以保持2,408 U / G(超过其初始活性的90%).磁性固定的pga由于pga的氨基与dmnf上的环氧基,邻苯二酚和邻苯二酚基的反应性基团的共价相互作用,使酶分子在载体之间共价偶联,从而显示出优异的操作稳定性.此外,
DOI:10.1002/jccs.201900559

专利信息

专利号:US-2016214860-A1
优先权日:2013-09-19
标题:Method of synthesis of unsolvated mixed cation borohydrides
发明人：JARON TOMASZ; WEGNER WOJCIECH; GROCHALA WOJCIECH
权利人:JAROÑ Tomasz; WEGNER WOJCIECH; GROCHALA WOJCIECH
摘要:The present invention relates to a novel method of synthesis of unsolvated mixed cation borohydrides of a general formula M x M′ y (BH 4 ) z , where M and M′ stand for metal cations, x, y, and z are stoichiometric coefficients. The method of synthesis according to the present invention is characterised in that the precursors having a general formula M[A n ] u and [Cat] v M′(BH 4 ) w are used for the synthesis, where [An] stands for a weakly coordinating anion; [Cat] stands for weakly coordinating cation; u, v, and w are the stoichiometric coefficients; and the synthesis is carried out under an inert to the reagents atmosphere—according to the general reaction equation: x M[An] u +y [Cat] v M′(BH 4 ) w →M x M′ y (BH 4 ) z +xu [Cat][An] where z=yw, xu=yv; M x M′ y (BH 4 ) z is the product of the reaction.

专利号:US-12404534-B1
优先权日:2024-10-29
标题:Method for separating amoxicillin and phenylacetic acid from reaction solution in one-step enzymatic synthesis of amoxicillin
发明人：YANG ZHONGHUA; YIN XIAOYAN
权利人:XINGZHI COLLEGE ZHEJIANG NORMAL UNIV
摘要:A method for separating amoxicillin and phenylacetic acid from reaction solution in one-step enzymatic synthesis of amoxicillin is provided. The method employs immobilized penicillin acylase mutant to catalyze the one-step synthesis of amoxicillin from penicillin potassium, and develops a separation process for the resulting reaction mixture. The technical scheme mainly comprises: Firstly separating the immobilized penicillin acylase mutant from the reaction solution through filtration; subsequently isolating amoxicillin via crystallization; followed by separating and recovering phenylacetic acid through toluene extraction and back extraction. This separation method enables rapid and efficient isolation of amoxicillin with high production yield, achieving an average crystallization rate of 93.22%. Concurrently, it demonstrates effective separation and recovery of phenylacetic acid while allowing recyclable use of the toluene extractant.

专利号:EP-2173892-B8
优先权日:2007-07-27
标题:Process for the preparation of immobilised recombinant Penicillin Acylase biocatalyst from Achromobacter sp CCM 4824 expressed in E. coli BL21 CCM 7394 and its use for the synthesis of beta-lactam antiobiotics
发明人：DATLA ANUPAMA; RAJASEKAR VYASARAYANI WILLIAMS; KYSLIK PAVEL; BECKA STANISLAV; KRISHNAKANT ASHAR TRUPTI; YOGESH ZAMBRE SUJATA; NIKUNJ KUMAR
权利人:FERMENTA BIOTECH LTD
摘要:The present invention discloses isolation of Penicillin Acylase (PA) from Achromobacter sp CCM 4824 expressed in recombinant strain E. coli BL21 CCM 7394 bearing the recombinant plasmid pKXIP1 and processing of PA into biocatalyst useful for the industrial synthesis of antibiotics. More particularly the invention discloses a synthesis of semi-synthetic β-lactam antibiotics in the reaction mixture consisting of activated acyl-donor (D-p-hydroxyphenylglycine methyl ester or amide for Amoxicillin and Cefadroxil; D-phenylglycine methyl ester or amide for Ampicillin and Cephalexin) and nucleophile (6-APA or 7-ADCA) catalyzed by PA obtained from recombinant E. coli BL21 CCM 7394 as the biocatalyst.

专利号:WO-2011113486-A1
优先权日:2010-03-17
标 题 :Process for the synthesis of hydroxyphenylglycine esters
发明人：PALLARES BAYO ANTONIO; LOPEZ SANCHEZ RAMON; SANTIANDREU LOPEZ RICARDO MANUEL
权利人:DERETIL S A; PALLARES BAYO ANTONIO; LOPEZ SANCHEZ RAMON; SANTIANDREU LOPEZ RICARDO MANUEL
摘要:The present invention refers to a process for the synthesis of a D-(-)-p-hydroxyphenylglycine (HPG) ester in crystal form, by crystallizing D-HPG ester from a solution containing dissolved D-HPG ester to obtain a suspension comprising D-HPG ester crystals, characterized in that the ee D of the D-HPG ester in the solution and the ee D of the D-HPG ester crystals is above 95%, preferably above 97%, more preferably above 98%, more preferably above 99%, more preferably above 99.5%.

专利号:US-6156534-A
优先权日:1996-07-26
标 题:Synthesis of β-lactam antibacterials using soluble side chain esters and enzyme acylase
发明人：USHER JOHN J; ROMANCIK GUNA
权利人:BRISTOL MYERS SQUIBB CO
摘要:Disclosed is a process for the synthesis of β-lactam antibacterials using soluble side chain esters in the presence of enzyme acylase. Also disclosed are novel esters useful as reactants in said process.

专利号:EP-0948511-B1
优先权日:1996-12-24
标 题:Chemical synthesis of nucleosides analogs and their incorporation into polynucleotides
发明人：KARPEISKY ALEXANDER; BEIGELMAN LEONID; MATULIC-ADAMIC JASENKA
权利人:SIRNA THERAPEUTICS INC
摘要:Novel nucleosides, process for chemical synthesis of nucleosides and incorporation of the nucleosides into polynucleotides are disclosed. Also described are polynucleotides, such as antisense, TFO and nucleic acid catalysts with one or more modifications, such as 2'-O-amino, L-nucleotides and the others.