CAS: 54696-05-8; 4-Benzyloxyacetophenone

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CAS号100-44-7 氯化苄 | CAS号99-93-4 对羟基苯乙酮 | CAS号100-39-0 溴化苄 | CAS号946-80-5 苄基苯基醚 | CAS号108-24-7 乙酸酐 | CAS号84284-70-8 4-苄氧基苯乙炔 | CAS号4254-67-5 2-溴-4'-苄氧基苯乙酮 | CAS号13031-43-1 4'-乙酰氧基苯乙酮 | CAS号93-99-2 苯甲酸苯酯 | CAS号111525-11-2 N-hydroxy-N-[1-... | CAS号142556-94-3 3-(hydroxymethy... | CAS号142472-13-7 1-(4-Benzyloxyp... | CAS号4254-67-5 2-溴-4'-苄氧基苯乙酮 | CAS号186029-00-5 (S)-A-甲基-4-(苯甲氧... | CAS号703402-21-5 (AR)-A-甲基-4-(苯甲... | CAS号99-93-4 对羟基苯乙酮 | CAS号32066-29-8 (4-羟基苯甲酰)乙酸甲酯 | CAS号84284-70-8 4-苄氧基苯乙炔 | CAS号32333-31-6 1-(2,2-二甲基-3,4-...

4-苄氧基苯乙炔置于盐酸,四(三苯基膦)钯体系中,用 四氢呋喃,水 作为反应溶剂,化学反应 48.0H,以80%的收率获得产物4-苯甲氧基苯乙酮
参考文献:抗衡离子促成的反应性开关:末端炔烃的高度化学选择性二聚和水合
标题:抗衡离子促成的反应性开关:末端炔烃的高度化学选择性二聚和水合
摘要:据报道,Pd催化的高化学选择性和区域选择性二聚化和末端炔烃的水合反应具有抗衡离子控制的反应性.使用乙酸盐作为抗衡离子有利于形成烯基炔基钯中间体,该中间体在还原消除后形成迄今报道较少的1,3-二芳基取代的共轭炔.使用作为较好离去基团的氯离子导致在烯基钯中间体上与氢氧化物进行阴离子交换,在还原消除和互变异构化之后,水合产物得以交换.
DOI:10.1021/ol403684A

专利信息

专利号:US-7737287-B2
优先权日:2002-03-28
标 题 :Anomeric derivatives of monosaccharides
发明人：MEUTERMANS WIM; WEST MICHAEL LEO; GIANG THANH LE; ADAMSON GEORGE; SCHAFER KARL; ABBENANTE GIOVANNI
权利人:ALCHEMIA LTD
摘要:This invention relates to combinatorial libraries of potentially biologically active mainly monosaccharide compounds and to methods of preparing same. These compounds are variously functionalized, with a view to varying lipid solubility, size, function and other properties, with the particular aim of discovering a drug or drug-like compound, or compounds with useful properties. The invention provides intermediates, processes and synthetic strategies for the solution or solid phase synthesis of monosaccharides, variously functionalized about the sugar ring, including the addition of aromaticity and charge, and the placement of amino acid and peptide side chain units of isosteres thereof.

专利号:US-6268499-B1
优先权日:1998-08-10
标 题 :Process and intermediates for preparation of substituted piperidine-epoxides
发明人：GUELLER ROLF; LOHRI BRUNO; SCHMID RUDOLF
权利人:HOFFMANN LA ROCHE
摘要:The present invention concerns intermediates useful in and a process for the preparation of a compound of formula 1 or a salt thereof n comprisingepoxidation of a compound of formula 2 or a salt thereof n wherein A, R 1 and R 2 are as herein defined. These compounds are useful in the synthesis of renin inhibitors.

专利号:US-6274735-B1
优先权日:1998-08-10
标 题 :Process and intermediates for preparation of substituted piperidines
发明人：LOHRI BRUNO; SCHMID RUDOLF; VIEIRA ERIC
权利人:HOFFMANN LA ROCHE
摘要:The present invention concerns intermediates useful in and a process for the preparation of a compound of formula 1 or a salt thereof n comprising n a) hydroboration of a compound of formula 2 n A, R 1 and R 2 are as herein defined. These compounds are useful in the synthesis of renin inhibitors.

专利号:US-6005103-A
优先权日:1993-11-19
标题 :Pyrone derivatives as protease inhibitors and antiviral agents
发明人：DOMAGALA JOHN MICHAEL; LUNNEY ELIZABETH; PARA KIMBERLY SUZANNE; PRASAD JOSYULA VENKATA NAGENDR; TAIT BRADLEY DEAN
权利人:WARNER LAMBERT CO
摘要:The present invention relates to novel tri- and tetrasubstituted pyrones and related structures which potently inhibit the HIV aspartyl protease blocking HIV infectivity. The pyrone derivatives are useful in the development of therapies for the treatment of bacterial and viral infections and diseases, including AIDS. The present invention is also directed to methods of synthesis of multifunctionalized pyrones and of related structures.

专利号:EP-0729465-B1
优先权日:1993-11-19
标 题:Pyrone derivatives as protease inhibitors and antiviral agents
发明人：DOMAGALA JOHN MICHAEL; LUNNEY ELIZABETH; PARA KIMBERLY SUZANNE; PRASAD JOSYULA VENKATA NAGENDR; TAIT BRADLEY DEAN
权利人:PARKE DAVIS & CO
摘要:The present invention relates to novel tri- and tetrasubstituted pyrones and related structures which potently inhibit the HIV aspartyl protease blocking HIV infectivity. The pyrone derivatives are useful in the development of therapies for the treatment of bacterial and viral infections and diseases, including AIDS. The present invention is also directed to methods of synthesis of multifunctionalized pyrones and of related structures.

专利号:US-8779201-B2
优先权日:2007-10-02
标题 :Process for preparing benzofurans
发明人：EKLUND LARS
权利人:CAMBREX KARLSKOGA AB
摘要:There is provided a process for the preparation of a compound of formula (I), wherein R 1 , R 2 , R 3 , R 4 , X and Y are as described in the description. Such compounds may, for example, be useful intermediates in the synthesis of drugs such as Dronedarone.