CAS: 52764-11-1; 2,6-Dichloropyridin-3-Ol

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6636-78-8 41288-96-4 1196157-47-7

上下游产品

CAS号148493-34-9 2,6-二氯-3-吡啶硼酸 | CAS号6636-78-8 2-氯-3-羟基吡啶 | CAS号2402-78-0 2,6-二氯吡啶 | CAS号1214340-74-5 2,6-二氯-3-甲氧基吡啶 | CAS号62804-93-7 ethyl 2-(2,6-di...

📜2,6-二氯吡啶置于正丁基锂,双氧水,二异丙胺体系中,用 四氢呋喃,正己烷,二氯甲烷,水 作为反应溶剂,化学反应 21.0H,反应生成 2,6-二氯-3-羟基吡啶
参考文献:Efficient Synthesis Of Halohydroxypyridines By Hydroxydeboronation
标题:Efficient Synthesis Of Halohydroxypyridines By Hydroxydeboronation
摘要:This Paper Describes A General Method For The Synthesis Of Halohydroxypyridines From Novel Halopyridinylboronic Acids And Esters Recently Described By Some Of Us. Halopyridinylboronic Acids And Esters Have Been Efficiently Hydroxydeboronated Under Mild Conditions By Employing Hydrogen Peroxide Or Meta-Chloroperbenzoic Acid. These Hydroxylations Take Place Regioselectively,Without Other Oxidation (N-Oxide Formation). (C) 2004 Elsevier Ltd. All Rights Reserved.
DOI:10.1016/j.Tet.2004.12.006

专利信息

专利号:US-9265773-B2
优先权日:2011-09-08
标题 :Tetracyclic heterocycle compounds and methods of use thereof for the treatment of viral diseases
发明人：MCCOMAS CASEY C; LIVERTON NIGEL J; HABERMANN JOERG; KOCH UWE; NARJES FRANK; LI PENG; PENG XUANJIA; SOLL RICHARD; WU HAO; PALANI ANANDAN; HE SHUWEN; DAI XING; LIU HONG; LAI ZHONG; LONDON CLARE; XIAO DONG; ZORN NICOLAS; NARGUND RAVI
权利人:MCCOMAS CASEY C; LIVERTON NIGEL J; HABERMANN JOERG; KOCH UWE; NARJES FRANK; LI PENG; PENG XUANJIA; SOLL RICHARD; WU HAO; PALANI ANANDAN; HE SHUWEN; DAI XING; LIU HONG; LAI ZHONG; LONDON CLARE; XIAO DONG; ZORN NICOLAS; NARGUND RAVI; MERCK SHARP & DOHME; MSD ITALIA SRL
摘要:The present invention relates to compounds of formula (I) that are useful as hepatitis C virus (HCV) NS5B polymerase inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5B polymerase activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system.