CAS: 50585-89-2; Methyl Piperidine-3-Carboxylate

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3-哌啶甲酸乙酯置于氰化钠,氨,Sodium Carbonate体系中,用 二氯甲烷,水 作为反应溶剂,化学反应 51.0H,反应生成 3-哌啶甲酸甲酯
参考文献:A Convenient Route To 1-Benzyl 3-Aminopyrrolidine And 3-Aminopiperidine
标题:A Convenient Route To 1-Benzyl 3-Aminopyrrolidine And 3-Aminopiperidine
摘要:1-Benzyl 3-Aminopyrrolidine 1 And 1-Benzyl 3-Aminopiperidine 2 Were Prepared Rapidly Mainly In Aqueous Conditions In 55 And 75%,Yields,Respectively,On A Multi-Gram Scale Starting From Inexpensive And Commercially Available Starting Materials. The Key Step Involved The Curtius Rearrangement Mediated By Sodium Nitrite And Trifluoroacetic Acid Of The Appropriate Acylhydrazides. All The Reactions (Except Lah Reductions) Were Performed In Water. (C) 2001 Elsevier Science Ltd. All Rights Reserved.
DOI:10.1016/s0040-4039(01)00985-6

专利信息

专利号:US-9370515-B2
优先权日:2013-03-07
标题 :Mixed lineage kinase inhibitors and method of treatments
发明人：GOODFELLOW VAL S; NGUYEN THONG X; RAVULA SATHEESH B; GELBARD HARRIS A
权利人:CALIFIA BIO INC; UNIV ROCHESTER
摘要:Provided herein are imidazopyridine compounds having an inhibitory effect on mixed lineage kinases (MLKs), methods of their synthesis, and methods of their therapeutic. Also provided are pharmaceutical compositions comprising the compounds and methods of using the compounds and pharmaceutical compositions.