专利号:US-12275733-B2 优先权日:2016-11-07 标 题:Substituted pyrido[3,4-b]indoles for the treatment of cartilage disorders 发明人:GRETZKE DIRK; RITZELER OLAF; HEINELT UWE; WEHNER VOLKMAR; SCHMIDT FRIEDEMANN 权利人:SANOFI SA 摘要:The present invention relates to 8-aryl-substituted and 8-heteroaryl-substituted 9H-pyrido[3,4-b]indoles of the formula (I), in which A, E, G, R1 to R6 and R10 are as defined in the claims, which stimulate chondrogenesis and cartilage matrix synthesis and can be used in the treatment of cartilage disorders and conditions in which a regeneration of damaged cartilage is desired, for example joint diseases such as osteoarthritis. The invention furthermore relates to processes for the synthesis of the compounds of the formula (I), their use as pharmaceuticals, and pharmaceutical compositions comprising them.
专利号:US-7192749-B2 优先权日:2002-05-16 标题 :Use of the repressor glxR for the synthesis of lysine in Corynebacterium glutamicum 发明人:KLOPPROGGE CORINNA; ZELDER OSKAR; KROEGER BURKHARD; SCHROEDER HARTWIG; HAEFNER STEFAN; LEE HEUNG-SHICK 权利人:BASF AG 摘要:Isolated polypeptide sequence having the sequence of SEQ ID NO:1 or muteins thereof having the ability to bind cAMP and repress the expression of the aceB gene of C. glutamicum and which can be obtained from SEQ ID NO:1 by inserting, deleting or substituting up to 20% of the amino acids.
专利号:US-10590158-B2 优先权日:2015-06-29 标题:Total synthesis of shishijimicin A and analogs thereof 发明人:NICOLAOU KYRIACOS C; LI RUOFAN; LU ZHAOYONG; SOHN TE-IK; WOODS JAMES; PITSINOS EMMANOUIL N 权利人:UNIV RICE WILLIAM M 摘要:In one aspect, the present disclosure provides shishijimicin analogs of the formula: wherein the variables are as defined herein. In another aspect, the present disclosure also provides methods of preparing the compounds disclosed herein. In another aspect, the present disclosure also provides pharmaceutical compositions and methods of use of the compounds disclosed herein. Additionally, antibody drug conjugates of the compounds are also provided.
专利号:US-9815694-B2 优先权日:2013-10-16 标 题 :Catalytic ammonia synthesis by transition metal molecular complexes 发明人:PETERS JONAS C; ANDERSON JOHN S; CRUETZ SIDNEY E; RITTLE JONATHAN D 权利人:CALIFORNIA INST OF TECHN 摘要:This invention relates to molecular catalysts and chemical reactions utilizing the same, and particularly to catalysts and catalytic methods for reduction of molecular nitrogen. The molecular catalytic platform provided herein is capable of the facile reduction of molecular nitrogen under useful conditions such as room temperature or less and atmospheric pressure or less.
专利号:US-8194868-B2 优先权日:2003-05-08 标 题:Loudspeaker system for virtual sound synthesis 发明人:HORBACH ULRICH; CORTEEL ETIENNE 权利人:HORBACH ULRICH; CORTEEL ETIENNE; HARMAN INT IND 摘要:A sound system obtains a desired sound field from an array of sound sources arranged on a panel. The desired sound field allows a listener to perceive the sound as if the sound were coming from a live source and from a specified location. Setup of the sound system includes arranging a microphone array adjacent the array of sound sources to obtain a generated sound field. Arbitrary finite impulse response filters are then composed for each sound source within the array of sound sources. Iteration is applied to optimize filter coefficients such that the generated sound field resembles the desired sound field so that multi-channel equalization and wave field synthesis occur. After the filters are setup, the microphones may be removed.
专利号:US-7790137-B2 优先权日:2006-08-14 标题:Metal telluride nanocrystals and synthesis thereof 发明人:XIAO QIANGFENG; LU YUNFENG; ZHANG MINJUAN 权利人:TOYOTA ENG & MFG NORTH AMERICA; UNIV TULANE 摘要:A process for synthesizing a metal telluride is provided that includes the dissolution of a metal precursor in a solvent containing a ligand to form a metal-ligand complex soluble in the solvent. The metal-ligand complex is then reacted with a telluride-containing reagent to form metal telluride domains having a mean linear dimension of from 2 to 40 nanometers. NaHTe represents a well-suited telluride reagent. A composition is provided that includes a plurality of metal telluride crystalline domains (PbTe)1-x-y(SnTe)x(Bi2Te3)y  (I) having a mean linear dimension of from 2 to 40 nanometers inclusive where x is between 0 and 1 inclusive and y is between 0 and 1 inclusive with the proviso that x+y is less than or equal to 1. Each of the metal telluride crystalline domains has a surface passivated with a saccharide moiety or a polydentate carboxylate. A densified mass having a density of greater than 95% of the theoretical density includes a plurality of lead telluride, tin telluride, bismuth telluride, or a combination thereof of domains having a mean linear dimension of from 2 to 40 nanometers inclusive that have been subjected to hot isotactic pressing.
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