CAS: 4706-17-6; 3-[bis(3-Hydroxypropyl)Phosphanyl]Propan-1-Ol

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CAS号107-18-6 烯丙醇 | CAS号51805-42-6 三(3-羟基丙基)氧化膦

3-[双-(2-甲氧基羰基乙基)-磷]-丙酸甲酯置于lithium Aluminium Tetrahydride体系中,用 四氢呋喃 作为反应溶剂,化学反应 4.0H,反应生成 三(3-羟基丙基)膦
参考文献: Novel Cytotoxic Agents For Conjugation Of Drugs To Cell Binding Molecule[fr] Nouveaux Agents Cytotoxiques Pour La Conjugaison De Médicaments Avec La Molécule De Liaison Cellulaire
标题: Novel Cytotoxic Agents For Conjugation Of Drugs To Cell Binding Molecule[fr] Nouveaux Agents Cytotoxiques Pour La Conjugaison De Médicaments Avec La Molécule De Liaison Cellulaire
摘要:提供了细胞毒性药物,吡咯并[2,1-C][1,4]苯二氮杂环己烷(pbd)衍生物,它们与细胞结合剂的结合物,以及在靶向治疗癌症,自身免疫性疾病和传染病中的制备和治疗用途.

专利信息

专利号:WO-2025075817-A1
优先权日:2023-10-02
标 题 :Methods for synthesis of protein hetero-polymers
发明人：SHRADER ALANNA SCHEPARTZ; ROE LEAH TANG
权利人:UNIV CALIFORNIA
摘要:A method for synthesis of protein hetero-polymers uses an intramolecular Backbone Extension Acyl Rearrangement (BEAR) reactions to orthogonally and site-specifically embed a β-, γ- or δ-amino acid residue into proteins.

专利号:WO-2023227913-A1
优先权日:2022-05-27
标 题:Creating nucleic acids for in-vitro protein synthesis
发明人：CHEN MICHAEL CHUN HAO; MCINROY GORDON ROSS; OST TOBIAS WILLIAM BARR
权利人:NUCLERA LTD
摘要:Provided herein are methods, and compositions for the synthesis of genes and proteins. The methods are applicable to synthesis of nucleic acids and proteins on a microfluidic device.

专利号:US-2025154546-A1
优先权日:2022-02-11
标题 :Use of 3'-oxymethylene alkyl disulfide protected nucleotides for enzymatic dna and rna synthesis
发明人：MARMA SANO MONG; SOLIMAN SAMEH; GUAN XIAO-PEI; PERBOST MICHEL; PINARD ROBERT
权利人:MILTENYI BIOTEC BV & CO KG
摘要:This invention is about enzymatic synthesis of nucleic acids using 3′-O—(CH2SSR) protected reversible nucleotide terminators. The nucleotide base of the protected nucleotide may consist of natural or non-natural (e.g. 7-de-aza G and 7-de-aza A), or mixture thereof. The base of the nucleotides can be modified with a linker carrying carboxylic acid (—CO2H). amine (—NH2), thiol (—SH). hydroxymethyl (—CH2OH), propargy lamine. alkyne group etc. for subsequent modification and labeling. Such nucleotide substrates can be incorporated into the single strand, template free nucleic acid or into the templated DNA hybrid. And in later step the 3′-O—CH2SSR protecting group can be cleaved off by chemical treatment pre-requisites for enzymatic nucleic acids synthesis. By adding nucleotide in pre-determined fashion and cleave reaction after each step. longer DNA strands can be synthesized in solution or on solid surface starting from a short seeding DNA strands.

专利号:US-2024271171-A1
优先权日:2019-11-29
标题:Enzymatic synthesis of oligonucleotides
发明人：ALLRED BENJAMIN; LI HANDONG
权利人:BGI SHENZHEN CO LTD
摘要:Provided are compositions and methods directed to using a short template and a polymerase or ligase to synthesize an oligonucleotide. The template is designed such that only one nucleotide is added to the primer in each round of synthesis.

专利号:US-12006540-B2
优先权日:2015-09-28
标题:Synthesis of novel disulfide linker based nucleotides as reversible terminators for DNA sequencing by synthesis
发明人：JU JINGYUE; LI XIAOXU; CHEN XIN; LI ZENGMIN; KUMAR SHIV; SHI SHUNDI; GUO CHENG; REN JIANYI; HSIEH MIN-KANG; CHIEN MINCHEN; TAO CHUANJUAN; ERTURK ECE; KALACHIKOV SERGEY; RUSSO JAMES J
权利人:UNIV COLUMBIA
摘要:Disclosed herein, inter alia, are compounds, compositions, and methods of use thereof in the sequencing of a nucleic acid.

专利号:US-9273410-B2
优先权日:2009-01-16
标 题 :Low-temperature synthesis of colloidal nanocrystals
发明人：BARTL MICHAEL H; SIY JACQUELINE T
权利人:BARTL MICHAEL H; SIY JACQUELINE T; UNIV UTAH RES FOUND
摘要:Low-temperature organometallic nucleation and crystallization-based synthesis methods for the fabrication of semiconductor and metal colloidal nanocrystals with narrow size distributions and tunable, size- and shape-dependent electronic and optical properties. Methods include (1) forming a reaction mixture in a reaction vessel under an inert atmosphere that includes at least one solvent, a cationic precursor, an anionic precursor, and at least a first surface stabilizing ligand while stirring at a temperature in a range from about 50° C. to about 130° C. and (2) growing nanocrystals in the reaction mixture for a period of time while maintaining the temperature, the stirring, and the inert-gas atmosphere.