CAS: 24851-98-7; Methyl 2-(3-Oxo-2-Pentylcyclopentyl)Acetate

相似化合物

24851-98-7 57069-78-0 10407-36-0

上下游产品

CAS号1101843-02-0 甲基茉莉酸酯(异构体的混和物) | CAS号24863-70-5 methyl 2-(3-oxo... | CAS号25564-22-1 2-戊基-2-环戊烯-1-酮 | CAS号108-59-8 丙二酸二甲酯 | CAS号51806-23-6 dimethyl (3-oxo... | CAS号694528-26-2 2-(1-hydroxypen... | CAS号1445-45-0 原乙酸三甲酯 | CAS号110-53-2 1-溴戊烷 | CAS号82259-82-3 methyl 2-pentyl... | CAS号75983-90-3 methyl (E)-3-ox... | CAS号3572-64-3 二氢茉莉酸 | CAS号24863-70-5 methyl 2-(3-oxo...

3-氧代-2-戊基-1-环戊烯-1-乙酸甲酯置于palladium On Activated Charcoal 氢气体系中,用 环己烷 用作溶剂,20.0 °C,101.32 Kpa 条件下,反应 1.5H,以100%的收率获得二氢茉莉酮酸甲酯
参考文献:合成顺式二氢茉莉酮酸甲酯®和茉莉酸甲酯通过级联贝里斯-希尔曼反应和克莱森原酸酯重排
标题:合成顺式二氢茉莉酮酸甲酯®和茉莉酸甲酯通过级联贝里斯-希尔曼反应和克莱森原酸酯重排
摘要:通过烯丙基羟基酮9的克莱森原酸酯重排而获得的环外不饱和共轭酮酯10直接加氢或部分异构化成环内不饱和四取代的二氢茉莉酮中间体14,然后在环己烷中用pd / C进行更选择性的氢化.生成二取代的氧代环戊烷乙酸酯15(方案2).关键中间体9通过四步序列要么获得,包括从烯酮缩醛保护/脱保护1,在羟基酮的特定情况下9A(方案1),或更直接地并且通常是通过环戊-2-En-1-酮(16)和适当的醛17的baylis-Hillman反应(方案2).这些醛的明智选择为立体选择性引入部分顺式-或差向异构反式-C(2)茉莉酮类侧链打开了通用的修饰,而手性[1,1'-双萘]-2催化的baylis-Hillman反应可以以一锅级联方式有效地进行1,2'-二醇(binols)19(方案3),包括原酸酯克莱森重排.
Doi:10.1002/hlca.200590248

专利信息

专利号:US-9796653-B2
优先权日:2015-12-21
标题 :Methods of preparing α,β-unsaturated or α-halo ketones and aldehydes
发明人：BAXENDALE IAN R; SHARLEY JAMES S; Miranda Amadeo Fernández; PÉREZ ANA MARIA COLLADO
权利人:INT FLAVORS & FRAGRANCES INC
摘要:Copper(II) bromide mediated oxidation of acylated enol and use of the reaction in the synthesis of α,β-unsaturated or α-bromo ketones or aldehydes are disclosed. The method provides an efficient and practical process for manufacturing dehydrohedione (DHH) and many other versatile α,β-unsaturated or α-bromo ketones or aldehydes in large scales to avoid using precious metal compounds.

专利号:EP-3628658-A1
优先权日:2018-09-28
标 题:Synthesis of substituted enones

专利号:US-11946019-B2
优先权日:2018-11-12
标 题:Synthesis and use of 2-ethyl-5,5-dimethyl-cyclohexanol as fragrance and flavor material

专利号:WO-2023144167-A1
优先权日:2022-01-25
标 题:Novel compositions for the sustainable catalysis of organic synthesis reactions

专利号:EP-4215267-A1
优先权日:2022-01-25
标 题 :Novel compositions for the sustainable catalysis of organic synthesis reactions

专利号:US-2021395639-A1
优先权日:2018-11-12
标 题 :Synthesis and use of 2-ethyl-5,5-dimethyl-cyclohexanol as fragrance and flavor material