CAS: 244-69-9; 5H-Pyrido[4,3-B]Indole

该化合物是一种环环生物化合物,其特点是其引信的和结构,该化合物具有双环框架,有助于其独特的化学特性,通常展示一种能够促进与生物目标互动的平板结构,使其对药用化学感兴趣. Pyrido [4,3-b] indole 以其潜在的生物活动(包括抗烟尘和抗微生物特性)著称,在各种研究中已经探讨过.该化合物一般在有机溶剂中溶解,其再活性可能受到无粉或细胞上存在功能组的影响.此外,它还可能经历各种化学变异,如氧化或替代反应,视反应情况而定.其独特的结构和特性使pyrido [4,3-b] indole 成为合成有机化学和药用研究的感兴趣对象.

结构式图片

相似化合物

1015460-56-6 1015460-59-9 1015460-62-4

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合成工艺路线路线简述

    1-(4-喹啉基)甲胺置于copper(L) Iodide,1,1'-双(二苯膦基)二茂铁二氯化钯(II)二氯甲烷复合物,Palladium On Activated Carbon,氢气,铜体系中,用 甲醇,二苯醚,二甲基亚砜 用作溶剂,化学反应 22.91H,反应生成5H-吡啶并[4,3-B]吲哚
    参考文献:A Unified Approach To The Isomeric α-,β-,γ-,And δ-Carbolines Via Their 6,7,8,9-Tetrahydro Counterparts
    标题:A Unified Approach To The Isomeric α-,β-,γ-,And δ-Carbolines Via Their 6,7,8,9-Tetrahydro Counterparts
    摘要:A Cross-Coupling/reductive Cyclization Protocol Has Been Employed In A Unified Approach To All Four Carbolines. So,For Example,The 2-Nitropyridine 8,Which Is Readily Prepared Through An Efficient Palladium-Catalyzed Ullmann Cross-Coupling Reaction,Is Reductively Cyclized Under Conventional Conditions To Give 6,7,8,9-Tetrahydro-Alpha-Carboline That Is Itself Readily Aromatized To Give Alpha-Carboline (1).
    Doi:10.1021/acs.Joc.7B00323

    海关参考信息

    专利信息


    专利号:US-11117893-B2
    优先权日:2018-09-24
    标题 :Methods for preparation of substituted pyridines and related novel compounds
    发明人:WATKINS EDMOND BLAKE; UREDI DILIPKUMAR; MOTATI DAMODER REDDY
    权利人:WATKINS EDMOND BLAKE; UREDI DILIPKUMAR; MOTATI DAMODER REDDY; UNION UNIV
    摘要:The present invention relates to novel methods of preparation of substituted pyridines and the compounds produced therefrom. In particular, the present invention provides efficient methods for the construction of diversely substituted pyridines, with varying substitution patterns under simple and metal-free conditions with high atom- and pot-economy and excellent functional group tolerance, and which are useful for the synthesis of natural products.

    专利号:US-9698359-B2
    优先权日:2011-05-26
    标 题 :Synthesis of platinum and palladium complexes as narrow-band phosphorescent emitters for full color displays
    发明人:LI JIAN; TURNER ERIC
    权利人:ARIZONA BOARD OF REGENTS ACTING FOR AND ON BEHALF OF ARIZONA STATE UNIV
    摘要:Platinum and palladium complexes are disclosed that can be useful as narrow band phosphorescent emitters. Also disclosed are methods for preparing and using the platinum and palladium complexes.

    专利号:US-9353092-B2
    优先权日:2013-06-27
    标题 :Synthesis and use of croconaine compounds
    发明人:SMITH BRADLEY
    权利人:UNIV NOTRE DAME DU LAC
    摘要:The present disclosure provides compositions and methods for the synthesis and use of croconaine compounds. The disclosed compounds are easily prepared from croconic acid. A halothiophene is reacted with an alkanolamine, the resulting aminothiophene is modified by appending a desired functional group to the hydroxyl group, and the modified aminothiophene is reacted with croconic acid to form the final compound. Applications of such croconaine compounds include photothermal imaging, photothermal therapy, light-activated drug release, and tissue welding.

    专利号:US-10804476-B2
    优先权日:2011-05-26
    标 题 :Synthesis of platinum and palladium complexes as narrow-band phosphorescent emitters for full color displays

    专利号:US-9359376-B2
    优先权日:2011-04-08
    标题:Substituted methylformyl reagents and method of using same to modify physicochemical and/or pharmacokinetic properties of compounds
    发明人:DUGAR SUNDEEP; MAHAJAN DINESH; HOLLINGER FRANK PETER
    权利人:DUGAR SUNDEEP; MAHAJAN DINESH; HOLLINGER FRANK PETER; SPHAERA PHARMA PTE LTD
    摘要:The present invention relates to the synthesis and application of novel chiral/achiral substituted methyl formyl reagents to modify pharmaceutical agents and/or biologically active substances to modify the physicochemical, biological and/or pharmacokinetic properties of the resulting compounds from the unmodified original agent.

    专利号:US-2020403167-A1
    优先权日:2011-05-26
    标 题:Synthesis of Platinum and Palladium Complexes as Narrow-Band Phosphorescent Emitters for Full Color Displays
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    合成参考文献


    摘要:Joule, J. A., Science of Synthesis Knowledge Updates, (2018) 2, 21.
    摘要:Joule, J. A., Science of Synthesis Knowledge Updates, (2018) 2, 257.
    摘要:Joule, J. A., Science of Synthesis Knowledge Updates, (2018) 2, 260.
    摘要:Joule, J. A., Science of Synthesis Knowledge Updates, (2018) 2, 293.
    摘要:Joule, J. A., Science of Synthesis Knowledge Updates, (2018) 2, 259.
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