CAS: 175278-17-8; 2-Bromo-4-(Trifluoromethoxy)Aniline

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CAS号461-82-5 对三氟甲氧基苯胺 | CAS号88149-49-9 2,6-二溴-4-(三氟甲氧基)苯胺 | CAS号468075-00-5 3-溴-4-氯三氟甲氧基苯 | CAS号549488-77-9 2-氨基-5-三氟甲氧基苯腈 | CAS号131395-29-4 N-(2-溴-4-(三氟甲氧基...

对三氟甲氧基苯胺置于氢溴酸,二甲基亚砜体系中,用 乙酸乙酯 用作溶剂,化学反应 12.0H,反应生成2-溴-4-三氟甲氧基苯胺
参考文献:从简单化学品直接合成结构不同的吲哚生物碱
标题:从简单化学品直接合成结构不同的吲哚生物碱
摘要:已开发出一种新颖的底物裂解/环加成策略,可从非常简单的2-乙烯基苯胺,炔烃和tbn直接合成并在结构上多样化的吲哚生物碱,这提供了一种无贵金属的有效方法,可访问高度有价值的吲哚衍生物库包括色胺和色胺相关的肟,内酰胺和内酯,以及β-咔啉,螺二吲哚和六氢吡咯并[2,3-B ]吲哚.
Doi:10.1002/cjoc.201800258

专利信息

专利号:US-12084422-B2
优先权日:2018-07-09
标 题 :Phenyl-n-quinoline derivatives for treating a RNA virus infection
发明人：SCHERRER DIDIER; TAZI JAMAL; MAHUTEAU-BETZER FLORENCE; NAJMAN ROMAIN; SANTO JULIEN; APOLIT CÉCILE
权利人:ABIVAX; CENTRE NAT RECH SCIENT; UNIV MONTPELLIER; INST CURIE
摘要:A compound of formula (I) or any of its pharmaceutically acceptable salt for use in the treatment and/or prevention of a RNA virus infection, and a RNA virus infection from group IV or V of the Baltimore classificationwherein R3 represents a chlorine atom or a hydrogen atom, R represents a (C1-C4)alkyl group, a (C3-C6)cycloalkyl group, a halogen atom, a (C1-C5)alkoxy group, a —SO2—NRaRb group, a —SO3H group, a —OH group, a —O—SO2—ORc group or a —O—P(â•?O)—(ORc)(ORd) group, R1 represents (i) a CF3 group, (ii) a (C1-C10)alkyl group, (iii) a (C3-C6)cycloalkyl or a (C3-C6)heterocycloalkyl group or (iv) a phenyl group or a naphthyl group, and R2 represents a hydrogen atom, a (C1-C10)alkyl group, a (C3-C6)cycloalkyl or a (C3-C6)heterocycloalkyl group and further relates to new compounds, to pharmaceutical compositions containing them and to synthesis process for manufacturing them.