氯乙醛置于氢氧化钾体系中,用 甲醇,水 用作溶剂,化学反应 0.5H,以63.5%的收率获得6,7-二氢-4(5H)-苯并呋喃酮 参考文献:3-Phenoxy-4-Pyridazinol Derivative And Herbicide Composition Containing The Same 标题:3-Phenoxy-4-Pyridazinol Derivative And Herbicide Composition Containing The Same
专利号:US-2007197797-A1 优先权日:2005-12-30 标 题 :Compounds and methods for carbazole synthesis 发明人:HARRINGTON PETER J 权利人:HARRINGTON PETER J 摘要:Compounds having bi-cyclic structure comprising a partially unsaturated 6-carbon first cyclic moiety interconnected to a 6-carbon second cyclic moiety second via a divalent linking moiety are provided. The compounds can be used as intermediates compounds in methods for the synthesis of carbazoles and derviatives thereof, including carvedilol, and tricyclic alkylhydroxamates, which do not require Fischer indole synthetic steps. Methods of preparing the compounds having bi-cyclic structures are also provided.
专利号:US-7179918-B2 优先权日:2001-06-11 标 题:HIV protease inhibitors, compositions containing the same, their pharmaceutical uses and materials for their synthesis 发明人:CANAN KOCH STACIE S; ALEXANDER THERESE N; BURKE BENJAMIN J; JEWELL TANYA M; KUCERA DAVID J; LINTON MARIA ANGELICA; MITCHELL JR LENNERT J; REICH SIEGFRIED H; SKALITZKY DONALD J; TATLOCK JOHN H; VARNEY MICHAEL D; VIRGIL SCOTT C; WEBBER STEPHEN E; WORLAND STEPHEN T; BARVIAN MARK; BOLTON GARY; BOYER JR FREDERICK EARL; MACHAK JEFFREY J; HOLLER TOD; MURPHY SEAN T; MELNICK MICHAEL; JOSYULA VARA PRASAD 权利人:AGOURON PHARMA 摘要:Compounds of the formula: n nwhere the formula variables are as defined herein, are disclosed that advantageously inhibit or block the biological activity of the HIV protease. These compounds, as well as pharmaceutical compositions containing these compounds, are useful for treating patients or hosts infected with the HIV virus. Intermediates and synthetic methods for preparing such compounds are also described.
专利号:US-4558143-A 优先权日:1982-08-06 标 题 :Process for preparing 4-oxo-4,5,6,7-tetrahydrobenzofuran 发明人:MATSUMOTO MASAKATSU; WATANABE NOBUKO 权利人:SAGAMI CHEM RES 摘要:A 4-oxo-4,5,6,7-tetrahydrobenzofuran derivative is prepared by reacting a 1,3-cyclohexanedione derivative with chloroacetaldehyde in the presence of a base while maintaining the reaction mixture at a pH of from 4 to 10, and treating the reaction mixture with an acid. The 4-oxo-4,5,6,7-tetrahydrobenzofuran derivatives are useful as an intermediate for synthesis of various kinds of drugs.
专利号:TW-509675-B 优先权日:1997-11-13 标 题 :Method of synthesis of pyrrole amides
专利号:US-7169932-B2 优先权日:2001-06-11 标题:HIV protease inhibitors, compositions containing the same, their pharmaceutical uses, material for their synthesis 发明人:KUCERA DAVID JOHN; SCOTT ROBERT WILLIAM 权利人:PFIZER 摘要:Compounds of the formula: n nwhere the formula variables are as defined herein, are disclosed that advantageously inhibit or block the biological activity of the HIV protease. These compounds, as well as pharmaceutical compositions containing these compounds, are useful for treating patients or hosts infected with the HIV virus. Intermediates and synthetic methods for preparing such compounds are also described.
专利号:US-7094909-B2 优先权日:2001-06-11 标 题 :HIV protease inhibitors, compositions containing the same, their pharmaceutical uses and materials for their synthesis 发明人:KUCERA DAVID JOHN; SCOTT ROBERT WILLIAM 权利人:AGOURON PHARMA 摘要:The present invention concerns processes for preparing compounds of formula (I-H), or a prodrug, pharmaceutically active metabolite, or pharmaceutically active salt or solvate thereof, n nwhich are useful as inhibitors of the HIV protease enzyme.
参考文献:10.1055/s-0040-1719875 摘要:Pettus TRR, Chan KK. Strategies for ortho-tert-Butylation of Phenols and their Analogues. Synlett. 2022 Jan 28;33(06):575–80. doi: 10.1055/s-0040-1719875. 参考文献:10.1007/s10593-024-03361-9 摘要:Adyukov IS, Pelipko VV, Litvinov IA, Mammeri OA, Baichurin RI, Makarenko SV. Synthesis of condensed furan structures based on 1-aryl-3-bromo-3-nitropropenones. Chem Heterocycl Comp. 2024 Sep;60(9-10):442–7. doi: 10.1007/s10593-024-03361-9. 参考文献:10.1007/s00706-025-03337-1 摘要:Gomonov KA, Pelipko VV, Litvinov IA, Baichurin RI, Makarenko SV. Synthesis of new 1,2,3-thiadiazole-containing furancarboxylates. Monatsh Chem. 2025 Jun 17;156(8-9):937–42. doi: 10.1007/s00706-025-03337-1.