CAS: 160885-98-3; Fmoc-Valinol
该化合物是一种受保护的氨基酒精衍生物,广泛用于peptide合成和有机化学;Fmoc(9-氟甲氧碳基)组作为氨基功能的临时保护组,在温和基本条件下有选择地取消保护;该化合物由于与基于Fmoc的战略相容,在固相基合成中特别宝贵;L-valine的手艺结构确保合成应用中的立体化学完整性;Fmoc-L-valinol也用于制作peptimitimics和其他生物活性分子,提供高纯度和可靠的再活动;其稳定性和易处理性使研究人员在医药化学和生物化学方面首选.
- 英文名称Fmoc-Valinol
- 中文名称N-Fmoc-L-缬氨醇
- 其它别名(S)-2-(Fmoc-氨基)-3-甲基-1-丁醇; N-Fmoc-L-Valinol
- CAS编号160885-98-3
- MFCD编号:MFCD00235961
- 分子式:C20H23NO3分子量:325.4
- 产品CID: 809876
- 产品分类有机原料→分子砌块→手性化合物→手性砌块
相似化合物
106391-87-1 2026-48-4 4276-09-9物理性质
MSDS等安全信息
上下游产品
CAS号68858-20-8 Fm°C-L-缬氨酸 | CAS号82911-80-6 Fm°C-Val-OMe | CAS号2026-48-4 L-缬氨醇 | CAS号28920-43-6 芴甲氧羰酰氯(Fm°C-Cl) | CAS号84890-99-3 Fm°C-Val-O-COO-isoBu | CAS号329308-98-7 Fm°C-Val-N3 | CAS号130878-68-1 FM°C-VAL-OSU合成工艺路线路线简述
📜Fmoc-L-缬氨酸置于n-甲基吗啉氧化物,氯甲酸异丁酯,Sodium Tetrahydroborate体系中,用 四氢呋喃,甲醇 用作溶剂,化学反应 1.17H,以47%的收率获得fmoc-缬氨醇
参考文献:Fusicoccin-肽共轭物的14-3-3-模板合成的无铜惠斯根环加成反应.
标题:Fusicoccin-肽共轭物的14-3-3-模板合成的无铜惠斯根环加成反应.
摘要:中型分子已成为一种有吸引力的化学空间,并有可能为开发控制细胞内蛋白质相互作用的合成剂提供坚实的基础.然而,这些试剂的有限的细胞渗透性和化学可延展性仍有待解决.我们设想了这种中等大小分子的目标模板合成可能会提供解决方案.在这里,我们在体外是否存在重组14-3-3ζ蛋白的情况下,利用包含4,8-二氮杂环壬炔(dacn)部分和含叠氮化物的fucicoccin衍生物的肽片段,利用无铜的huisgen环加成法进行模板合成. .产物收率随时间的变化表明,在14-3-3存在下,反应加快,并且主要生成一种区域异构体,
Doi:10.1002/asia.202000042
海关参考信息
- 2902600000-乙苯
2905121000-正丙醇
2905130000-正丁醇
2912110000-甲醛 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:US-9206222-B2
优先权日:2009-06-29
标题:Solid phase peptide synthesis of peptide alcohols
发明人：CAUSSIL-AMBLARD MURIEL; MARTINEZ JEAN; TAILHADES JULIEN
权利人:CAUSSIL-AMBLARD MURIEL; MARTINEZ JEAN; TAILHADES JULIEN; CENTRE NAT RECH SCIENT
摘要:The present invention relates to the synthesis of depsipeptides on solid phase support. Said depsipeptides are then implicated in a solution phase O—N acyl shift enabling to obtain the corresponding peptide alcohols.
专利号:US-2025282825-A1
优先权日:2020-11-20
标 题 :Novel cyclic compounds, method for their preparation and the use of said cyclic compounds in cosmetic preparations
发明人：WIRTZ SEBASTIAN N; GROND STEPHANIE; SAUR JULIAN S; KRISMER BERNHARD; HEUER ANDREA; HUEPEDEN JENNIFER
权利人:UNIV EBERHARD KARLS TUEBINGEN
摘要:The present invention relates to novel cyclic compounds; a method for the solid phase synthesis of said novel cyclic compounds; novel thiazolidine and oxazolidine building blocks that can be directly incorporated into the solid phase synthesis of said novel cyclic compounds, and a novel method for the synthesis of said thiazolidine and oxazolidine building blocks; and cosmetic compositions containing said novel cyclic compounds.
专利号:US-2012108748-A1
优先权日:2009-06-29
标 题:Solid phase peptide synthesis of peptide alcohols
专利号:EP-2448956-B1
优先权日:2009-06-29
标题:Solid phase peptide synthesis of peptide alcohols
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
主要参考文献
参考标题:An Expedient Route For The Reduction Of Carboxylic Acids To Alcohols Employing 1-Propanephosphonic Acid Cyclic Anhydride As Acid Activator作者:G. Nagendra,C. Madhu,T.M. Vishwanatha,Vommina V. Sureshbabu |发布日期:2012.9
摘要:Method For The Synthesis Of Alcohols From The Corresponding Carboxylic Acids Is Described. Activation Of Carboxylic Acid With 1-Propanephosphonic Acid Cyclic Anhydride (T3P) And Subsequent Reduction Using Nabh4 Yield The Alcohol In Excellent Yields With Good Purity. Reduction Of Several Alkyl/aryl Carboxylic Acids And Nα-Protected Amino Acids/peptide Acids As Well As Nβ-Protected Amino Acids Was Successfully
合成参考文献
参考文献:10.1055/s-0041-1737198
摘要:Back to the Carbonyl: Iron-Catalyzed Degradation of Alcohols by C–C Bond Cleavage. Synfacts. 2021 Dec 17;18(01):0055. doi: 10.1055/s-0041-1737198.
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